Fatty acid bioconversions by Pseudomonas aeruginosa PR3
The bioconversions of oleic acid, linoleic acid, and ricinoleic acid by Pseudomonas aeruginosa PR3 were investigated. The conversion of oleic acid to 7,10‐dihydroxy‐8(E)‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microb...
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| Veröffentlicht in: | Journal of the American Oil Chemists' Society 1998-07, Vol.75 (7), p.875-879 |
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| creator | Kuo, T.M Manthey, L.K Hou, C.T |
| description | The bioconversions of oleic acid, linoleic acid, and ricinoleic acid by Pseudomonas aeruginosa PR3 were investigated. The conversion of oleic acid to 7,10‐dihydroxy‐8(E)‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microbial cultures were stable and retained the same level of DOD production capacity for up to 6 mon as examined herewith. Strain PR3 did not bioconvert linoleic acid. However, strain PR3 converted ricinoleic acid to a novel compound, 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid (TOD), with a yield of about 35%. The product was further metabolized by strain PR3. TOD was purified by thin‐layer chromatography, and its structure was determined by 1H and 13C nuclear magnetic resonance and mass spectrometry. This is the first report on the production of 7,10,12‐trihydroxy unsaturated fatty acid by microbial transformation. |
| doi_str_mv | 10.1007/s11746-998-0240-3 |
| format | Article |
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The conversion of oleic acid to 7,10‐dihydroxy‐8(E)‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microbial cultures were stable and retained the same level of DOD production capacity for up to 6 mon as examined herewith. Strain PR3 did not bioconvert linoleic acid. However, strain PR3 converted ricinoleic acid to a novel compound, 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid (TOD), with a yield of about 35%. The product was further metabolized by strain PR3. TOD was purified by thin‐layer chromatography, and its structure was determined by 1H and 13C nuclear magnetic resonance and mass spectrometry. This is the first report on the production of 7,10,12‐trihydroxy unsaturated fatty acid by microbial transformation.</description><identifier>ISSN: 0003-021X</identifier><identifier>EISSN: 1558-9331</identifier><identifier>DOI: 10.1007/s11746-998-0240-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>7,10,12‐trihydroxy‐8(E)‐unsaturated fatty acid ; ACIDE GRAS ; ACIDE LINOLEIQUE ; ACIDE OLEIQUE ; ACIDO LINOLEICO ; ACIDO OLEICO ; ACIDOS GRASOS ; Bioconversions ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; dihydroxy unsaturated fatty acid ; FATTY ACIDS ; Fundamental and applied biological sciences. Psychology ; LINOLEIC ACID ; Methods. Procedures. Technologies ; OLEIC ACID ; PSEUDOMONAS AERUGINOSA ; RICINOLEIC ACID</subject><ispartof>Journal of the American Oil Chemists' Society, 1998-07, Vol.75 (7), p.875-879</ispartof><rights>1998 American Oil Chemists' Society (AOCS)</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4395-a4189ef886e938ea30a5d884ccbfe250819668f11ba283b967d473aa4ebd88553</citedby><cites>FETCH-LOGICAL-c4395-a4189ef886e938ea30a5d884ccbfe250819668f11ba283b967d473aa4ebd88553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11746-998-0240-3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11746-998-0240-3$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2329965$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuo, T.M</creatorcontrib><creatorcontrib>Manthey, L.K</creatorcontrib><creatorcontrib>Hou, C.T</creatorcontrib><title>Fatty acid bioconversions by Pseudomonas aeruginosa PR3</title><title>Journal of the American Oil Chemists' Society</title><description>The bioconversions of oleic acid, linoleic acid, and ricinoleic acid by Pseudomonas aeruginosa PR3 were investigated. The conversion of oleic acid to 7,10‐dihydroxy‐8(E)‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microbial cultures were stable and retained the same level of DOD production capacity for up to 6 mon as examined herewith. Strain PR3 did not bioconvert linoleic acid. However, strain PR3 converted ricinoleic acid to a novel compound, 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid (TOD), with a yield of about 35%. The product was further metabolized by strain PR3. TOD was purified by thin‐layer chromatography, and its structure was determined by 1H and 13C nuclear magnetic resonance and mass spectrometry. This is the first report on the production of 7,10,12‐trihydroxy unsaturated fatty acid by microbial transformation.</description><subject>7,10,12‐trihydroxy‐8(E)‐unsaturated fatty acid</subject><subject>ACIDE GRAS</subject><subject>ACIDE LINOLEIQUE</subject><subject>ACIDE OLEIQUE</subject><subject>ACIDO LINOLEICO</subject><subject>ACIDO OLEICO</subject><subject>ACIDOS GRASOS</subject><subject>Bioconversions</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>dihydroxy unsaturated fatty acid</subject><subject>FATTY ACIDS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>LINOLEIC ACID</subject><subject>Methods. Procedures. Technologies</subject><subject>OLEIC ACID</subject><subject>PSEUDOMONAS AERUGINOSA</subject><subject>RICINOLEIC ACID</subject><issn>0003-021X</issn><issn>1558-9331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkEFLwzAUx4MoOKcfwIPQg3ir5iVNkxzHcCoMNpwDb-E1S0ela2ayKvv2tlS8eno83v_34_En5BroPVAqHyKAzPJUa5VSltGUn5ARCKFSzTmckhGllHcXeD8nFzF-dKviTIyInOHhcEzQVpukqLz1zZcLsfJNTIpjsoyu3fidbzAm6EK7rRofMVm-8ktyVmId3dXvHJP17PFt-pzOF08v08k8tRnXIsUMlHalUrnTXDnkFMVGqczaonRMUAU6z1UJUCBTvNC53GSSI2au6GJC8DG5G7z74D9bFw9mV0Xr6hob59toGDDBBPAuCEPQBh9jcKXZh2qH4WiAmr4iM1RkuopMX5HpmdtfOUaLdRmwsVX8AxlnWuf9D3KIfVe1O_7vNZPFdEWV7MmbgSzRG9yGTr5egdaSSgFK8B8-235k</recordid><startdate>199807</startdate><enddate>199807</enddate><creator>Kuo, T.M</creator><creator>Manthey, L.K</creator><creator>Hou, C.T</creator><general>Springer-Verlag</general><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>199807</creationdate><title>Fatty acid bioconversions by Pseudomonas aeruginosa PR3</title><author>Kuo, T.M ; Manthey, L.K ; Hou, C.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4395-a4189ef886e938ea30a5d884ccbfe250819668f11ba283b967d473aa4ebd88553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>7,10,12‐trihydroxy‐8(E)‐unsaturated fatty acid</topic><topic>ACIDE GRAS</topic><topic>ACIDE LINOLEIQUE</topic><topic>ACIDE OLEIQUE</topic><topic>ACIDO LINOLEICO</topic><topic>ACIDO OLEICO</topic><topic>ACIDOS GRASOS</topic><topic>Bioconversions</topic><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>dihydroxy unsaturated fatty acid</topic><topic>FATTY ACIDS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>LINOLEIC ACID</topic><topic>Methods. Procedures. Technologies</topic><topic>OLEIC ACID</topic><topic>PSEUDOMONAS AERUGINOSA</topic><topic>RICINOLEIC ACID</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuo, T.M</creatorcontrib><creatorcontrib>Manthey, L.K</creatorcontrib><creatorcontrib>Hou, C.T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of the American Oil Chemists' Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuo, T.M</au><au>Manthey, L.K</au><au>Hou, C.T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty acid bioconversions by Pseudomonas aeruginosa PR3</atitle><jtitle>Journal of the American Oil Chemists' Society</jtitle><date>1998-07</date><risdate>1998</risdate><volume>75</volume><issue>7</issue><spage>875</spage><epage>879</epage><pages>875-879</pages><issn>0003-021X</issn><eissn>1558-9331</eissn><abstract>The bioconversions of oleic acid, linoleic acid, and ricinoleic acid by Pseudomonas aeruginosa PR3 were investigated. The conversion of oleic acid to 7,10‐dihydroxy‐8(E)‐octadecenoic acid (DOD) was improved to better than 80% yields by modifying the culture medium and reaction parameters. The microbial cultures were stable and retained the same level of DOD production capacity for up to 6 mon as examined herewith. Strain PR3 did not bioconvert linoleic acid. However, strain PR3 converted ricinoleic acid to a novel compound, 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid (TOD), with a yield of about 35%. The product was further metabolized by strain PR3. TOD was purified by thin‐layer chromatography, and its structure was determined by 1H and 13C nuclear magnetic resonance and mass spectrometry. This is the first report on the production of 7,10,12‐trihydroxy unsaturated fatty acid by microbial transformation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><doi>10.1007/s11746-998-0240-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the American Oil Chemists' Society, 1998-07, Vol.75 (7), p.875-879 |
| issn | 0003-021X 1558-9331 |
| language | eng |
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| subjects | 7,10,12‐trihydroxy‐8(E)‐unsaturated fatty acid ACIDE GRAS ACIDE LINOLEIQUE ACIDE OLEIQUE ACIDO LINOLEICO ACIDO OLEICO ACIDOS GRASOS Bioconversions Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology dihydroxy unsaturated fatty acid FATTY ACIDS Fundamental and applied biological sciences. Psychology LINOLEIC ACID Methods. Procedures. Technologies OLEIC ACID PSEUDOMONAS AERUGINOSA RICINOLEIC ACID |
| title | Fatty acid bioconversions by Pseudomonas aeruginosa PR3 |
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