A phase II study of high‐dose calcitriol combined with mitoxantrone and prednisone for androgen‐independent prostate cancer

OBJECTIVE To evaluate the preliminary efficacy, safety, and impact on quality of life (QoL) of high‐dose calcitriol (DN‐101) combined with mitoxantrone and glucocorticoids in androgen‐independent prostate cancer (AIPC). PATIENTS AND METHODS Nineteen patients with metastatic AIPC and no previous chem...

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Veröffentlicht in:	BJU international 2008-12, Vol.102 (11), p.1601-1606
Hauptverfasser:	Chan, Joseph S., Beer, Tomasz M., Quinn, David I., Pinski, Jacek K., Garzotto, Mark, Sokoloff, Mitchell, Dehaze, Daniel R., Ryan, Christopher W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Administration, Oral Aged Aged, 80 and over Androgens - metabolism Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences calcitriol Calcitriol - administration & dosage DN‐101 Gynecology. Andrology. Obstetrics Humans Infusions, Intravenous Male Male genital diseases Medical sciences Middle Aged mitoxantrone Mitoxantrone - administration & dosage Nephrology. Urinary tract diseases Prednisone - administration & dosage prostate cancer Prostate-Specific Antigen - metabolism Prostatic Neoplasms - drug therapy Quality of Life Treatment Outcome Tumors Tumors of the urinary system Urinary tract. Prostate gland
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