Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005)
A novel antibiotic complex was purified from a strain of Streptomyces tendae , isolated from the wall of an ancient cave in southern Italy, shown in the cover picture. These polyketide glycosides, cervimycins A–D, demonstrated potent activity against multi‐drug‐resistant staphylococci and vancomycin...
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| Veröffentlicht in: | Chemistry : a European journal 2005-09, Vol.11 (19), p.5475-5475 |
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| container_end_page | 5475 |
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| container_issue | 19 |
| container_start_page | 5475 |
| container_title | Chemistry : a European journal |
| container_volume | 11 |
| creator | Herold, Kerstin Gollmick, Friedrich A. Groth, Ingrid Roth, Martin Menzel, Klaus-Dieter Möllmann, Ute Gräfe, Udo Hertweck, Christian |
| description | A novel antibiotic complex
was purified from a strain of
Streptomyces tendae
, isolated from the wall of an ancient cave in southern Italy, shown in the cover picture. These polyketide glycosides, cervimycins A–D, demonstrated potent activity against multi‐drug‐resistant staphylococci and vancomycin‐resistant enterococci. Results of NMR and chemical degredation studies revealed the cervimycins to have a common tetracyclic polyketide core substituted with unusual di‐ and tetrasaccharide chains (see picture), but with differences in their acetyl and carbamoyl ring substituents, and in the terminal methylmalonyl and dimethylmalonyl residues. For more details, see the Full Paper by C. Hertweck and co‐workers on page 5523 ff. |
| doi_str_mv | 10.1002/chem.200590060 |
| format | Article |
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was purified from a strain of
Streptomyces tendae
, isolated from the wall of an ancient cave in southern Italy, shown in the cover picture. These polyketide glycosides, cervimycins A–D, demonstrated potent activity against multi‐drug‐resistant staphylococci and vancomycin‐resistant enterococci. Results of NMR and chemical degredation studies revealed the cervimycins to have a common tetracyclic polyketide core substituted with unusual di‐ and tetrasaccharide chains (see picture), but with differences in their acetyl and carbamoyl ring substituents, and in the terminal methylmalonyl and dimethylmalonyl residues. For more details, see the Full Paper by C. Hertweck and co‐workers on page 5523 ff.</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.200590060</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>antibiotics ; Bacteria ; glycosides ; natural products ; polyketides ; streptomyces ; Streptomyces tendae</subject><ispartof>Chemistry : a European journal, 2005-09, Vol.11 (19), p.5475-5475</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Herold, Kerstin</creatorcontrib><creatorcontrib>Gollmick, Friedrich A.</creatorcontrib><creatorcontrib>Groth, Ingrid</creatorcontrib><creatorcontrib>Roth, Martin</creatorcontrib><creatorcontrib>Menzel, Klaus-Dieter</creatorcontrib><creatorcontrib>Möllmann, Ute</creatorcontrib><creatorcontrib>Gräfe, Udo</creatorcontrib><creatorcontrib>Hertweck, Christian</creatorcontrib><title>Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005)</title><title>Chemistry : a European journal</title><addtitle>Chemistry - A European Journal</addtitle><description>A novel antibiotic complex
was purified from a strain of
Streptomyces tendae
, isolated from the wall of an ancient cave in southern Italy, shown in the cover picture. These polyketide glycosides, cervimycins A–D, demonstrated potent activity against multi‐drug‐resistant staphylococci and vancomycin‐resistant enterococci. Results of NMR and chemical degredation studies revealed the cervimycins to have a common tetracyclic polyketide core substituted with unusual di‐ and tetrasaccharide chains (see picture), but with differences in their acetyl and carbamoyl ring substituents, and in the terminal methylmalonyl and dimethylmalonyl residues. For more details, see the Full Paper by C. Hertweck and co‐workers on page 5523 ff.</description><subject>antibiotics</subject><subject>Bacteria</subject><subject>glycosides</subject><subject>natural products</subject><subject>polyketides</subject><subject>streptomyces</subject><subject>Streptomyces tendae</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNo9UMtOwzAQtBBIlMKVs08IDkn9iJ2EW0lLASGoEBRulutuRCCpi51U5B_4aBIVcdrXzGh2EDqlJKSEsJF5hypkhIiUEEn20IAKRgMeS7GPBiSN4kAKnh6iI-8_CCGp5HyAfjK7BYfnhakbB5c4A7ctqtYUazwOJpd4jOe2bD-hLlaAZ2VrrO-7zFabEr5x7myFNc70FvCVNjW4oqm6cY0nkIOu8UKvjd3pPYEvfN3NgM-z3iueNi7EdyGm6aj3fXGMDnJdejj5q0P0cj19zm6C-8fZbTa-DwwlSRQsI5bwXHMhl5SlUZKTpUhNIlJNo1gmqwQIiygDE8vuoMWKMpkb4Ix3e72ifIjOdrobZ78a8LWqCm-gLPUabOMVoyySNIk6YLgDGme9d5CrjSsq7VpFiepDV33o6j_0jhDsCN2n8P2P1u5TyZjHQr0-zNQiSyaUzt8U47-Z_IEp</recordid><startdate>20050919</startdate><enddate>20050919</enddate><creator>Herold, Kerstin</creator><creator>Gollmick, Friedrich A.</creator><creator>Groth, Ingrid</creator><creator>Roth, Martin</creator><creator>Menzel, Klaus-Dieter</creator><creator>Möllmann, Ute</creator><creator>Gräfe, Udo</creator><creator>Hertweck, Christian</creator><general>WILEY-VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20050919</creationdate><title>Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005)</title><author>Herold, Kerstin ; Gollmick, Friedrich A. ; Groth, Ingrid ; Roth, Martin ; Menzel, Klaus-Dieter ; Möllmann, Ute ; Gräfe, Udo ; Hertweck, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1084-b4283fa356b12948f0b59c859a14768d8e02412ec76b59a5d126fce323024ad13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>antibiotics</topic><topic>Bacteria</topic><topic>glycosides</topic><topic>natural products</topic><topic>polyketides</topic><topic>streptomyces</topic><topic>Streptomyces tendae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herold, Kerstin</creatorcontrib><creatorcontrib>Gollmick, Friedrich A.</creatorcontrib><creatorcontrib>Groth, Ingrid</creatorcontrib><creatorcontrib>Roth, Martin</creatorcontrib><creatorcontrib>Menzel, Klaus-Dieter</creatorcontrib><creatorcontrib>Möllmann, Ute</creatorcontrib><creatorcontrib>Gräfe, Udo</creatorcontrib><creatorcontrib>Hertweck, Christian</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herold, Kerstin</au><au>Gollmick, Friedrich A.</au><au>Groth, Ingrid</au><au>Roth, Martin</au><au>Menzel, Klaus-Dieter</au><au>Möllmann, Ute</au><au>Gräfe, Udo</au><au>Hertweck, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005)</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry - A European Journal</addtitle><date>2005-09-19</date><risdate>2005</risdate><volume>11</volume><issue>19</issue><spage>5475</spage><epage>5475</epage><pages>5475-5475</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>A novel antibiotic complex
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| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2005-09, Vol.11 (19), p.5475-5475 |
| issn | 0947-6539 1521-3765 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | antibiotics Bacteria glycosides natural products polyketides streptomyces Streptomyces tendae |
| title | Cover Picture: Cervimycin A-D: A Polyketide Glycoside Complex from a Cave Bacterium Can Defeat Vancomycin Resistance (Chem. Eur. J. 19/2005) |
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