Environmental investigation of a legionellosis outbreak in western Sydney: the role of molecular profiling
This investigation used DNA profiling in an attempt to identify the environmental source of a community outbreak of 11 cases of Legionnaires? disease. Nine of these cases were culture positive and a single strain (DNA profile) of Legionella pneumophila serogroup 1 was isolated from eight cases. Spot...
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| Veröffentlicht in: | Australian and New Zealand journal of public health 1998-08, Vol.22 (4), p.428-431 |
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| container_title | Australian and New Zealand journal of public health |
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| creator | Heath, Timothy C. Roberts, Christine Jalaludin, Bin Goldthrope, Ian Capon, Anthonly G. |
| description | This investigation used DNA profiling in an attempt to identify the environmental source of a community outbreak of 11 cases of Legionnaires? disease. Nine of these cases were culture positive and a single strain (DNA profile) of Legionella pneumophila serogroup 1 was isolated from eight cases. Spot water samples were collected from 51 cooling towers implicated by case exposure histories; this same strain was isolated from four towers at three separate locations up to 6 km apart. None of these locations had been frequently implicated by case histories. Because we did not perform an analytic epidemiological investigation, we were unable to identify a single environmental source for the outbreak. It is also possible that this outbreak was multifocal. The use of molecular profiling should not overshadow the importance of epidemiological methods in these environmental investigations. More data is needed regarding the prevalence, distribution, and clinical significance (virulence) of environmental L. pneumophila strains. This would aid interpretation of molecular profiling used in investigations of community legionellosis outbreaks. |
| doi_str_mv | 10.1111/j.1467-842X.1998.tb01408.x |
| format | Article |
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Nine of these cases were culture positive and a single strain (DNA profile) of Legionella pneumophila serogroup 1 was isolated from eight cases. Spot water samples were collected from 51 cooling towers implicated by case exposure histories; this same strain was isolated from four towers at three separate locations up to 6 km apart. None of these locations had been frequently implicated by case histories. Because we did not perform an analytic epidemiological investigation, we were unable to identify a single environmental source for the outbreak. It is also possible that this outbreak was multifocal. The use of molecular profiling should not overshadow the importance of epidemiological methods in these environmental investigations. More data is needed regarding the prevalence, distribution, and clinical significance (virulence) of environmental L. pneumophila strains. 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Roberts, Christine ; Jalaludin, Bin ; Goldthrope, Ian ; Capon, Anthonly G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6138-edd36a92d445097e1c4ed0bfbd50721e5443d4ae19372293162afd7ade710deb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Australia - epidemiology</topic><topic>Bacterial Typing Techniques</topic><topic>Case histories</topic><topic>Cooling towers</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Outbreaks</topic><topic>DNA</topic><topic>DNA fingerprinting</topic><topic>DNA fingerprints</topic><topic>DNA, Bacterial - classification</topic><topic>Environmental Pollution - analysis</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Legionella pneumophila</topic><topic>Legionella pneumophila - classification</topic><topic>Legionnaires' disease</topic><topic>Legionnaires' Disease - diagnosis</topic><topic>Legionnaires' Disease - epidemiology</topic><topic>Legionnaires' Disease - microbiology</topic><topic>Legionnaires' disease bacterium</topic><topic>Outbreaks</topic><topic>Polymerase chain reaction</topic><topic>Public health</topic><topic>Sensitivity and Specificity</topic><topic>Species Specificity</topic><topic>Urban Population</topic><topic>Virulence</topic><topic>Water analysis</topic><topic>Water sampling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heath, Timothy C.</creatorcontrib><creatorcontrib>Roberts, Christine</creatorcontrib><creatorcontrib>Jalaludin, Bin</creatorcontrib><creatorcontrib>Goldthrope, Ian</creatorcontrib><creatorcontrib>Capon, Anthonly G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>PAIS Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PAIS International</collection><collection>PAIS International (Ovid)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Safety Science and Risk</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><jtitle>Australian and New Zealand journal of public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heath, Timothy C.</au><au>Roberts, Christine</au><au>Jalaludin, Bin</au><au>Goldthrope, Ian</au><au>Capon, Anthonly G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental investigation of a legionellosis outbreak in western Sydney: the role of molecular profiling</atitle><jtitle>Australian and New Zealand journal of public health</jtitle><addtitle>Aust N Z J Public Health</addtitle><date>1998-08</date><risdate>1998</risdate><volume>22</volume><issue>4</issue><spage>428</spage><epage>431</epage><pages>428-431</pages><issn>1326-0200</issn><eissn>1753-6405</eissn><abstract>This investigation used DNA profiling in an attempt to identify the environmental source of a community outbreak of 11 cases of Legionnaires? disease. 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| ispartof | Australian and New Zealand journal of public health, 1998-08, Vol.22 (4), p.428-431 |
| issn | 1326-0200 1753-6405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21246098 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; PAIS Index; Alma/SFX Local Collection |
| subjects | Australia - epidemiology Bacterial Typing Techniques Case histories Cooling towers Deoxyribonucleic acid Disease Outbreaks DNA DNA fingerprinting DNA fingerprints DNA, Bacterial - classification Environmental Pollution - analysis Epidemics Epidemiology Humans Legionella pneumophila Legionella pneumophila - classification Legionnaires' disease Legionnaires' Disease - diagnosis Legionnaires' Disease - epidemiology Legionnaires' Disease - microbiology Legionnaires' disease bacterium Outbreaks Polymerase chain reaction Public health Sensitivity and Specificity Species Specificity Urban Population Virulence Water analysis Water sampling |
| title | Environmental investigation of a legionellosis outbreak in western Sydney: the role of molecular profiling |
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