Rabies post-exposure prophylaxis with purified equine rabies immunoglobulin: One-year follow-up of patients with laboratory-confirmed category III rabies exposure in the Philippines
Abstract Category III rabies post-exposure prophylaxis (PEP) encompasses wound cleansing, infiltration of rabies immunoglobulins (RIG) and rabies vaccination. A Manila-based prospective prescription monitoring one-year follow-up study enrolled 193 patients, aged 16 months–79 years. Patients received...
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| Veröffentlicht in: | Vaccine 2009-11, Vol.27 (51), p.7162-7166 |
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| creator | Quiambao, Beatriz P Dy-Tioco, Hazel Z Dizon, Ruby M Crisostomo, Marilyn E Teuwen, Dirk E |
| description | Abstract Category III rabies post-exposure prophylaxis (PEP) encompasses wound cleansing, infiltration of rabies immunoglobulins (RIG) and rabies vaccination. A Manila-based prospective prescription monitoring one-year follow-up study enrolled 193 patients, aged 16 months–79 years. Patients received PEP, including infiltration of highly purified equine RIG (pERIG, Favirab™), following exposure to animals confirmed rabid by direct fluorescence antibody test (dFAT). No serious adverse events were considered related to PEP. One-year post-exposure, 191 of the 193 patients (99%) were in good health. Two deaths occurred, one due to myocardial infarction (unrelated to rabies) in a 73-year-old man, 291 days post-exposure, and one due to rabies infection in a six-year-old boy, 28 days post-exposure. The results show the recommended PEP treatment is highly effective. The single rabies fatality demonstrates the importance of ensuring immediate and complete application of recommended PEP, sustained education and training in rabies management. |
| doi_str_mv | 10.1016/j.vaccine.2009.09.036 |
| format | Article |
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A Manila-based prospective prescription monitoring one-year follow-up study enrolled 193 patients, aged 16 months–79 years. Patients received PEP, including infiltration of highly purified equine RIG (pERIG, Favirab™), following exposure to animals confirmed rabid by direct fluorescence antibody test (dFAT). No serious adverse events were considered related to PEP. One-year post-exposure, 191 of the 193 patients (99%) were in good health. Two deaths occurred, one due to myocardial infarction (unrelated to rabies) in a 73-year-old man, 291 days post-exposure, and one due to rabies infection in a six-year-old boy, 28 days post-exposure. The results show the recommended PEP treatment is highly effective. The single rabies fatality demonstrates the importance of ensuring immediate and complete application of recommended PEP, sustained education and training in rabies management.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2009.09.036</identifier><identifier>PMID: 19925947</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Allergy and Immunology ; Animal bites ; Animals ; Bites and Stings - drug therapy ; Child ; Child, Preschool ; Dogs ; Exposure ; Female ; Follow-Up Studies ; Health Status ; Horses - immunology ; Humans ; Immunoglobulins - administration & dosage ; Immunoglobulins - therapeutic use ; Infant ; Infiltration ; Laboratories ; Male ; Middle Aged ; Myocardial infarction ; Philippines ; Philippines - epidemiology ; Post-Exposure Prophylaxis ; Post-exposure prophylaxis (PEP) ; Prophylaxis ; Prospective Studies ; Purified equine rabies immunoglobulin (pERIG) ; Rabies ; Rabies - epidemiology ; Rabies - prevention & control ; Rabies - therapy ; Rabies Vaccines - therapeutic use ; Vaccines ; Wound healing ; Young Adult</subject><ispartof>Vaccine, 2009-11, Vol.27 (51), p.7162-7166</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>Copyright Elsevier Limited Nov 27, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-233ee137c03483380bd4585699136df50ba0a556f7da442db8e2e9832b526a6d3</citedby><cites>FETCH-LOGICAL-c509t-233ee137c03483380bd4585699136df50ba0a556f7da442db8e2e9832b526a6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X09013607$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19925947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quiambao, Beatriz P</creatorcontrib><creatorcontrib>Dy-Tioco, Hazel Z</creatorcontrib><creatorcontrib>Dizon, Ruby M</creatorcontrib><creatorcontrib>Crisostomo, Marilyn E</creatorcontrib><creatorcontrib>Teuwen, Dirk E</creatorcontrib><title>Rabies post-exposure prophylaxis with purified equine rabies immunoglobulin: One-year follow-up of patients with laboratory-confirmed category III rabies exposure in the Philippines</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Category III rabies post-exposure prophylaxis (PEP) encompasses wound cleansing, infiltration of rabies immunoglobulins (RIG) and rabies vaccination. A Manila-based prospective prescription monitoring one-year follow-up study enrolled 193 patients, aged 16 months–79 years. Patients received PEP, including infiltration of highly purified equine RIG (pERIG, Favirab™), following exposure to animals confirmed rabid by direct fluorescence antibody test (dFAT). No serious adverse events were considered related to PEP. One-year post-exposure, 191 of the 193 patients (99%) were in good health. Two deaths occurred, one due to myocardial infarction (unrelated to rabies) in a 73-year-old man, 291 days post-exposure, and one due to rabies infection in a six-year-old boy, 28 days post-exposure. The results show the recommended PEP treatment is highly effective. The single rabies fatality demonstrates the importance of ensuring immediate and complete application of recommended PEP, sustained education and training in rabies management.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Animal bites</subject><subject>Animals</subject><subject>Bites and Stings - drug therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dogs</subject><subject>Exposure</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Status</subject><subject>Horses - immunology</subject><subject>Humans</subject><subject>Immunoglobulins - administration & dosage</subject><subject>Immunoglobulins - therapeutic use</subject><subject>Infant</subject><subject>Infiltration</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Philippines</subject><subject>Philippines - epidemiology</subject><subject>Post-Exposure Prophylaxis</subject><subject>Post-exposure prophylaxis (PEP)</subject><subject>Prophylaxis</subject><subject>Prospective Studies</subject><subject>Purified equine rabies immunoglobulin (pERIG)</subject><subject>Rabies</subject><subject>Rabies - epidemiology</subject><subject>Rabies - prevention & control</subject><subject>Rabies - therapy</subject><subject>Rabies Vaccines - therapeutic use</subject><subject>Vaccines</subject><subject>Wound healing</subject><subject>Young 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post-exposure prophylaxis with purified equine rabies immunoglobulin: One-year follow-up of patients with laboratory-confirmed category III rabies exposure in the Philippines</title><author>Quiambao, Beatriz P ; Dy-Tioco, Hazel Z ; Dizon, Ruby M ; Crisostomo, Marilyn E ; Teuwen, Dirk E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-233ee137c03483380bd4585699136df50ba0a556f7da442db8e2e9832b526a6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Animal bites</topic><topic>Animals</topic><topic>Bites and Stings - drug therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dogs</topic><topic>Exposure</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Status</topic><topic>Horses - immunology</topic><topic>Humans</topic><topic>Immunoglobulins - administration & dosage</topic><topic>Immunoglobulins - therapeutic use</topic><topic>Infant</topic><topic>Infiltration</topic><topic>Laboratories</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Philippines</topic><topic>Philippines - epidemiology</topic><topic>Post-Exposure Prophylaxis</topic><topic>Post-exposure prophylaxis (PEP)</topic><topic>Prophylaxis</topic><topic>Prospective Studies</topic><topic>Purified equine rabies immunoglobulin (pERIG)</topic><topic>Rabies</topic><topic>Rabies - epidemiology</topic><topic>Rabies - prevention & control</topic><topic>Rabies - therapy</topic><topic>Rabies Vaccines - therapeutic use</topic><topic>Vaccines</topic><topic>Wound healing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quiambao, Beatriz P</creatorcontrib><creatorcontrib>Dy-Tioco, Hazel 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Philippines</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2009-11-27</date><risdate>2009</risdate><volume>27</volume><issue>51</issue><spage>7162</spage><epage>7166</epage><pages>7162-7166</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Category III rabies post-exposure prophylaxis (PEP) encompasses wound cleansing, infiltration of rabies immunoglobulins (RIG) and rabies vaccination. A Manila-based prospective prescription monitoring one-year follow-up study enrolled 193 patients, aged 16 months–79 years. Patients received PEP, including infiltration of highly purified equine RIG (pERIG, Favirab™), following exposure to animals confirmed rabid by direct fluorescence antibody test (dFAT). No serious adverse events were considered related to PEP. One-year post-exposure, 191 of the 193 patients (99%) were in good health. Two deaths occurred, one due to myocardial infarction (unrelated to rabies) in a 73-year-old man, 291 days post-exposure, and one due to rabies infection in a six-year-old boy, 28 days post-exposure. The results show the recommended PEP treatment is highly effective. The single rabies fatality demonstrates the importance of ensuring immediate and complete application of recommended PEP, sustained education and training in rabies management.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19925947</pmid><doi>10.1016/j.vaccine.2009.09.036</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Allergy and Immunology Animal bites Animals Bites and Stings - drug therapy Child Child, Preschool Dogs Exposure Female Follow-Up Studies Health Status Horses - immunology Humans Immunoglobulins - administration & dosage Immunoglobulins - therapeutic use Infant Infiltration Laboratories Male Middle Aged Myocardial infarction Philippines Philippines - epidemiology Post-Exposure Prophylaxis Post-exposure prophylaxis (PEP) Prophylaxis Prospective Studies Purified equine rabies immunoglobulin (pERIG) Rabies Rabies - epidemiology Rabies - prevention & control Rabies - therapy Rabies Vaccines - therapeutic use Vaccines Wound healing Young Adult |
| title | Rabies post-exposure prophylaxis with purified equine rabies immunoglobulin: One-year follow-up of patients with laboratory-confirmed category III rabies exposure in the Philippines |
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