Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension
Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneou...
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| Veröffentlicht in: | Journal of vascular research 1999-03, Vol.36 (2), p.139-146 |
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| container_title | Journal of vascular research |
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| creator | Clerc, Ph. Chamiot Renaud, J.F. Blacher, J. Legrand, M. Samuel, J.L. Levy, B.I. Sassard, J. Safar, M.E. |
| description | Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls. |
| doi_str_mv | 10.1159/000025637 |
| format | Article |
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Chamiot ; Renaud, J.F. ; Blacher, J. ; Legrand, M. ; Samuel, J.L. ; Levy, B.I. ; Sassard, J. ; Safar, M.E.</creator><creatorcontrib>Clerc, Ph. Chamiot ; Renaud, J.F. ; Blacher, J. ; Legrand, M. ; Samuel, J.L. ; Levy, B.I. ; Sassard, J. ; Safar, M.E.</creatorcontrib><description>Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls.</description><identifier>ISSN: 1018-1172</identifier><identifier>EISSN: 1423-0135</identifier><identifier>DOI: 10.1159/000025637</identifier><identifier>PMID: 10213910</identifier><identifier>CODEN: JVREE9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Aorta - pathology ; Aorta - physiopathology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - pathology ; Carotid Arteries - physiopathology ; Collagen - genetics ; Collagen - physiology ; Elasticity ; Experimental diseases ; Hypertension - genetics ; Hypertension - pathology ; Hypertension - physiopathology ; In Situ Hybridization ; Isomerism ; Male ; Medical sciences ; Rats ; Rats, Inbred SHR ; Rats, Inbred Strains ; Rats, Inbred WKY ; Research Paper ; RNA, Messenger - metabolism</subject><ispartof>Journal of vascular research, 1999-03, Vol.36 (2), p.139-146</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright S. 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Chamiot</creatorcontrib><creatorcontrib>Renaud, J.F.</creatorcontrib><creatorcontrib>Blacher, J.</creatorcontrib><creatorcontrib>Legrand, M.</creatorcontrib><creatorcontrib>Samuel, J.L.</creatorcontrib><creatorcontrib>Levy, B.I.</creatorcontrib><creatorcontrib>Sassard, J.</creatorcontrib><creatorcontrib>Safar, M.E.</creatorcontrib><title>Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension</title><title>Journal of vascular research</title><addtitle>J Vasc Res</addtitle><description>Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls.</description><subject>Animals</subject><subject>Aorta - pathology</subject><subject>Aorta - physiopathology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. 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Chamiot</au><au>Renaud, J.F.</au><au>Blacher, J.</au><au>Legrand, M.</au><au>Samuel, J.L.</au><au>Levy, B.I.</au><au>Sassard, J.</au><au>Safar, M.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension</atitle><jtitle>Journal of vascular research</jtitle><addtitle>J Vasc Res</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>36</volume><issue>2</issue><spage>139</spage><epage>146</epage><pages>139-146</pages><issn>1018-1172</issn><eissn>1423-0135</eissn><coden>JVREE9</coden><abstract>Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10213910</pmid><doi>10.1159/000025637</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of vascular research, 1999-03, Vol.36 (2), p.139-146 |
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| subjects | Animals Aorta - pathology Aorta - physiopathology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - pathology Carotid Arteries - physiopathology Collagen - genetics Collagen - physiology Elasticity Experimental diseases Hypertension - genetics Hypertension - pathology Hypertension - physiopathology In Situ Hybridization Isomerism Male Medical sciences Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY Research Paper RNA, Messenger - metabolism |
| title | Collagen I and III and Mechanical Properties of Conduit Arteries in Rats with Genetic Hypertension |
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