A Cyclic Peptide Inhibitor of the iNOS–SPSB Protein–Protein Interaction as a Potential Anti-Infective Agent

SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causing the iNOS to be polyubiquitinated and targeted for degradation. Inhibition of this interaction increases iNOS levels, and consequently cellular nitric oxide (NO) concent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ACS chemical biology 2018-10, Vol.13 (10), p.2930-2938
Hauptverfasser:	Sadek, Maiada M, Barlow, Nicholas, Leung, Eleanor W. W, Williams-Noonan, Billy J, Yap, Beow Keat, Shariff, Fairolniza Mohd, Caradoc-Davies, Tom T, Nicholson, Sandra E, Chalmers, David K, Thompson, Philip E, Law, Ruby H. P, Norton, Raymond S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Drug Design Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Mice Nitric Oxide Synthase Type II - metabolism Oligopeptides - chemistry Oligopeptides - pharmacology Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Protein Binding RAW 264.7 Cells Suppressor of Cytokine Signaling Proteins - chemistry Suppressor of Cytokine Signaling Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!