Improvement of Normothermic Ex Vivo Machine Perfusion of Rat Liver Grafts by Dialysis and Kupffer Cell Inhibition With Glycine

Normothermic ex vivo liver machine perfusion might be a superior preservation strategy for liver grafts from extended criteria donors. However, standardized small animal models are not available for basic research on machine perfusion of liver grafts. A laboratory‐scaled perfusion system was develop...

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Veröffentlicht in:	Liver transplantation 2019-02, Vol.25 (2), p.275-287
Hauptverfasser:	Gassner, Joseph M. G. V., Nösser, Maximilian, Moosburner, Simon, Horner, Rosa, Tang, Peter, Wegener, Lara, Wyrwal, David, Claussen, Felix, Arsenic, Ruza, Pratschke, Johann, Sauer, Igor M., Raschzok, Nathanael
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts - cytology Allografts - drug effects Allografts - pathology Animal models Animals Bile Caspase Caspase-3 Cell culture Deoxyribonucleic acid Dialysis Disease Models, Animal DNA Erythrocytes Extracorporeal Circulation Glycine Glycine - pharmacology Hemodiafiltration - instrumentation Hemodiafiltration - methods Hemodialysis Humans Kupffer cells Kupffer Cells - drug effects Laboratories Liver Liver - cytology Liver - drug effects Liver - pathology Liver Transplantation Male mRNA Organ Preservation - instrumentation Organ Preservation - methods Organ Preservation Solutions - chemistry Organ Preservation Solutions - pharmacology Perfusion Perfusion - instrumentation Perfusion - methods Portal vein Preservation Pressure Rats Rats, Wistar Reperfusion Injury - pathology Reperfusion Injury - prevention & control Rodents Temperature Transaminase Tumor necrosis factor-α Urea
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