Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate
This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) e...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2019-03, Vol.120, p.101-113 |
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| creator | Ervolino, Edilson Statkievicz, Cristian Toro, Luan Felipe de Mello-Neto, João Martins Cavazana, Thamires Priscila Issa, João Paulo Mardegan Dornelles, Rita Cássia Menegati de Almeida, Juliano Milanezi Nagata, Maria José Hitomi Okamoto, Roberta Casatti, Cláudio Aparecido Garcia, Valdir Gouveia Theodoro, Leticia Helena |
| description | This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNFα), interleukin (IL)-1β and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction.
•Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a serious adverse effect of therapies with anti-resorptive drugs.•BRONJ is a difficult to treat condition.•Antimicrobial photodynamic therapy (aPDT) was effective, safe and able to prevent the occurrence of BRONJ-like lesions in rats. |
| doi_str_mv | 10.1016/j.bone.2018.10.014 |
| format | Article |
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•Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a serious adverse effect of therapies with anti-resorptive drugs.•BRONJ is a difficult to treat condition.•Antimicrobial photodynamic therapy (aPDT) was effective, safe and able to prevent the occurrence of BRONJ-like lesions in rats.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2018.10.014</identifier><identifier>PMID: 30339908</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - pathology ; Alveolar Process - drug effects ; Alveolar Process - pathology ; Animals ; Anti-Infective Agents - therapeutic use ; Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy ; Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control ; Bisphosphonate-related osteonecrosis of the jaws ; Collagen - metabolism ; Female ; Interleukin-1beta - metabolism ; Interleukin-6 - metabolism ; Mouth Mucosa - pathology ; Osteogenesis ; Photochemotherapy ; Prevention ; Rats, Wistar ; Tartrate-Resistant Acid Phosphatase - metabolism ; Tooth Extraction - adverse effects ; Tooth socket ; Tumor Necrosis Factor-alpha - metabolism ; Wound healing ; Wound Healing - drug effects ; Zoledronic Acid - adverse effects</subject><ispartof>Bone (New York, N.Y.), 2019-03, Vol.120, p.101-113</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-7c02c842ffce87c386236ed56571d076bf87603a93f2c6bb217ccab6035e46273</citedby><cites>FETCH-LOGICAL-c382t-7c02c842ffce87c386236ed56571d076bf87603a93f2c6bb217ccab6035e46273</cites><orcidid>0000-0003-4859-0583 ; 0000-0002-1049-4257</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328218303946$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30339908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Statkievicz, Cristian</creatorcontrib><creatorcontrib>Toro, Luan Felipe</creatorcontrib><creatorcontrib>de Mello-Neto, João Martins</creatorcontrib><creatorcontrib>Cavazana, Thamires Priscila</creatorcontrib><creatorcontrib>Issa, João Paulo Mardegan</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>de Almeida, Juliano Milanezi</creatorcontrib><creatorcontrib>Nagata, Maria José Hitomi</creatorcontrib><creatorcontrib>Okamoto, Roberta</creatorcontrib><creatorcontrib>Casatti, Cláudio Aparecido</creatorcontrib><creatorcontrib>Garcia, Valdir Gouveia</creatorcontrib><creatorcontrib>Theodoro, Leticia Helena</creatorcontrib><title>Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNFα), interleukin (IL)-1β and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction.
•Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a serious adverse effect of therapies with anti-resorptive drugs.•BRONJ is a difficult to treat condition.•Antimicrobial photodynamic therapy (aPDT) was effective, safe and able to prevent the occurrence of BRONJ-like lesions in rats.</description><subject>Aging - pathology</subject><subject>Alveolar Process - drug effects</subject><subject>Alveolar Process - pathology</subject><subject>Animals</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control</subject><subject>Bisphosphonate-related osteonecrosis of the jaws</subject><subject>Collagen - metabolism</subject><subject>Female</subject><subject>Interleukin-1beta - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Osteogenesis</subject><subject>Photochemotherapy</subject><subject>Prevention</subject><subject>Rats, Wistar</subject><subject>Tartrate-Resistant Acid Phosphatase - metabolism</subject><subject>Tooth Extraction - adverse effects</subject><subject>Tooth socket</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Zoledronic Acid - adverse effects</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uGyEUhVHVqnHTvkAXFctuxuXHA1jqJoqaNFKkbNo1YuCOjDUDU8BO3ZfLqxXktMusuPo491wuB6GPlKwpoeLLfj3EAGtGqKpgTejmFVpRJXnHpOCv0UrJXnScKXaB3uW8J4TwraRv0QUnnG-3RK3Q01UofvY2xcGbCS-7WKI7BVMRLjtIZjlhPy8pHiE3gM10hDiZhBMsxidcryzkjE1wtYYjhHIWRmsPKUGwtRxxzAXqY-uc7HMDTbI3j7VxLJBwibHsMPwuydjiY8A-4AzBT4CTaY4JTAGHH32V_YkTuBRDJe_Rm9FMGT48n5fo5823H9ffu_uH27vrq_vOcsVKJy1hVm3YOFpQsjLBuADXi15SR6QYRiUF4WbLR2bFMDAqrTVDRT1sBJP8En0--9Z9fx0gFz37bGGaTIB4yJpRxiUjfS-qlJ2lbdmcYNRL8rNJJ02JbsHpvW7B6RZcYzW42vTp2f8wzOD-t_xLqgq-ngVQtzx6SDpb337X-QS2aBf9S_5_ASE-r9Q</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Ervolino, Edilson</creator><creator>Statkievicz, Cristian</creator><creator>Toro, Luan Felipe</creator><creator>de Mello-Neto, João Martins</creator><creator>Cavazana, Thamires Priscila</creator><creator>Issa, João Paulo Mardegan</creator><creator>Dornelles, Rita Cássia Menegati</creator><creator>de Almeida, Juliano Milanezi</creator><creator>Nagata, Maria José Hitomi</creator><creator>Okamoto, Roberta</creator><creator>Casatti, Cláudio Aparecido</creator><creator>Garcia, Valdir Gouveia</creator><creator>Theodoro, Leticia Helena</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4859-0583</orcidid><orcidid>https://orcid.org/0000-0002-1049-4257</orcidid></search><sort><creationdate>20190301</creationdate><title>Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate</title><author>Ervolino, Edilson ; Statkievicz, Cristian ; Toro, Luan Felipe ; de Mello-Neto, João Martins ; Cavazana, Thamires Priscila ; Issa, João Paulo Mardegan ; Dornelles, Rita Cássia Menegati ; de Almeida, Juliano Milanezi ; Nagata, Maria José Hitomi ; Okamoto, Roberta ; Casatti, Cláudio Aparecido ; Garcia, Valdir Gouveia ; Theodoro, Leticia Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-7c02c842ffce87c386236ed56571d076bf87603a93f2c6bb217ccab6035e46273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aging - pathology</topic><topic>Alveolar Process - drug effects</topic><topic>Alveolar Process - pathology</topic><topic>Animals</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control</topic><topic>Bisphosphonate-related osteonecrosis of the jaws</topic><topic>Collagen - metabolism</topic><topic>Female</topic><topic>Interleukin-1beta - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Mouth Mucosa - pathology</topic><topic>Osteogenesis</topic><topic>Photochemotherapy</topic><topic>Prevention</topic><topic>Rats, Wistar</topic><topic>Tartrate-Resistant Acid Phosphatase - metabolism</topic><topic>Tooth Extraction - adverse effects</topic><topic>Tooth socket</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Zoledronic Acid - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Statkievicz, Cristian</creatorcontrib><creatorcontrib>Toro, Luan Felipe</creatorcontrib><creatorcontrib>de Mello-Neto, João Martins</creatorcontrib><creatorcontrib>Cavazana, Thamires Priscila</creatorcontrib><creatorcontrib>Issa, João Paulo Mardegan</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>de Almeida, Juliano Milanezi</creatorcontrib><creatorcontrib>Nagata, Maria José Hitomi</creatorcontrib><creatorcontrib>Okamoto, Roberta</creatorcontrib><creatorcontrib>Casatti, Cláudio Aparecido</creatorcontrib><creatorcontrib>Garcia, Valdir Gouveia</creatorcontrib><creatorcontrib>Theodoro, Leticia Helena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ervolino, Edilson</au><au>Statkievicz, Cristian</au><au>Toro, Luan Felipe</au><au>de Mello-Neto, João Martins</au><au>Cavazana, Thamires Priscila</au><au>Issa, João Paulo Mardegan</au><au>Dornelles, Rita Cássia Menegati</au><au>de Almeida, Juliano Milanezi</au><au>Nagata, Maria José Hitomi</au><au>Okamoto, Roberta</au><au>Casatti, Cláudio Aparecido</au><au>Garcia, Valdir Gouveia</au><au>Theodoro, Leticia Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>120</volume><spage>101</spage><epage>113</epage><pages>101-113</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNFα), interleukin (IL)-1β and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction.
•Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a serious adverse effect of therapies with anti-resorptive drugs.•BRONJ is a difficult to treat condition.•Antimicrobial photodynamic therapy (aPDT) was effective, safe and able to prevent the occurrence of BRONJ-like lesions in rats.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30339908</pmid><doi>10.1016/j.bone.2018.10.014</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4859-0583</orcidid><orcidid>https://orcid.org/0000-0002-1049-4257</orcidid></addata></record> |
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| subjects | Aging - pathology Alveolar Process - drug effects Alveolar Process - pathology Animals Anti-Infective Agents - therapeutic use Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control Bisphosphonate-related osteonecrosis of the jaws Collagen - metabolism Female Interleukin-1beta - metabolism Interleukin-6 - metabolism Mouth Mucosa - pathology Osteogenesis Photochemotherapy Prevention Rats, Wistar Tartrate-Resistant Acid Phosphatase - metabolism Tooth Extraction - adverse effects Tooth socket Tumor Necrosis Factor-alpha - metabolism Wound healing Wound Healing - drug effects Zoledronic Acid - adverse effects |
| title | Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate |
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