Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study
Intestinal colonization by extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) has been attributed to travel to high prevalence countries. However, the dynamics of the microbiota changes during ESC-R-Ent colonization and whether there is a particular bacterial composition which...
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| Veröffentlicht in: | Travel medicine and infectious disease 2019-01, Vol.27, p.72-80 |
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| creator | Pires, João Kraemer, Julia G. Kuenzli, Esther Kasraian, Sara Tinguely, Regula Hatz, Christoph Endimiani, Andrea Hilty, Markus |
| description | Intestinal colonization by extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) has been attributed to travel to high prevalence countries. However, the dynamics of the microbiota changes during ESC-R-Ent colonization and whether there is a particular bacterial composition which is associated with subsequent colonization is unknown.
Forty healthy volunteers living in Switzerland underwent screening before and after a trip to India, and also 3, 6 and 12 months after traveling. Culture-based ESC-R-Ent screening and microbiota analysis based on 16S rRNA amplicon sequencing were performed at all time points.
Prevalence of ESC-R-Ent colonization before traveling was 10% (n = 4), whereas it increased to 76% (n = 31) after the trip. Based on bacterial diversity analyses of the gut microbiota, there were few but significant differences for colonized versus non-colonized individuals. However, an alternative, cluster based analysis revealed that individuals remained in the same cluster over time indicating that neither traveling nor ESC-R-Ent colonization significantly influences bacterial composition. Moreover, none of the found microbiota clusters were significantly associated with subsequent risk of ESC-R-Ent colonization.
Based on their microbiota patterns, every volunteer was at the same risk of ESC-R-Ent colonization while traveling to India. Therefore, other risk factors for ESC-R-Ent colonization are responsible for this phenomenon. |
| doi_str_mv | 10.1016/j.tmaid.2018.10.012 |
| format | Article |
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Forty healthy volunteers living in Switzerland underwent screening before and after a trip to India, and also 3, 6 and 12 months after traveling. Culture-based ESC-R-Ent screening and microbiota analysis based on 16S rRNA amplicon sequencing were performed at all time points.
Prevalence of ESC-R-Ent colonization before traveling was 10% (n = 4), whereas it increased to 76% (n = 31) after the trip. Based on bacterial diversity analyses of the gut microbiota, there were few but significant differences for colonized versus non-colonized individuals. However, an alternative, cluster based analysis revealed that individuals remained in the same cluster over time indicating that neither traveling nor ESC-R-Ent colonization significantly influences bacterial composition. Moreover, none of the found microbiota clusters were significantly associated with subsequent risk of ESC-R-Ent colonization.
Based on their microbiota patterns, every volunteer was at the same risk of ESC-R-Ent colonization while traveling to India. Therefore, other risk factors for ESC-R-Ent colonization are responsible for this phenomenon.</description><identifier>ISSN: 1477-8939</identifier><identifier>EISSN: 1873-0442</identifier><identifier>DOI: 10.1016/j.tmaid.2018.10.012</identifier><identifier>PMID: 30339827</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Antimicrobial agents ; Antimicrobial resistance ; Bacteria ; Cephalosporins - pharmacology ; Cluster Analysis ; Colonization ; Composition ; Deoxyribonucleic acid ; DNA ; Drug Resistance, Multiple, Bacterial ; Dynamics ; Enterobacteriaceae ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - genetics ; Enterobacteriaceae Infections - epidemiology ; ESBL ; Feces - microbiology ; Female ; Food chains ; Gastrointestinal Microbiome ; Health care ; Healthy Volunteers ; Humans ; India ; Infectious diseases ; Intestinal colonization ; Intestinal flora ; Longitudinal Studies ; Male ; MDR bacteria ; Microbiota ; Middle Aged ; Prevalence ; Prospective Studies ; Risk factors ; RNA, Ribosomal, 16S - genetics ; Switzerland ; Time Factors ; Travel ; Travel medicine ; Travel-Related Illness</subject><ispartof>Travel medicine and infectious disease, 2019-01, Vol.27, p.72-80</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-2dfb9b58028fe3c520f19d3d4668b02689efdb1f54ab6663a0c1a6ef7e8fd7413</citedby><cites>FETCH-LOGICAL-c387t-2dfb9b58028fe3c520f19d3d4668b02689efdb1f54ab6663a0c1a6ef7e8fd7413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2194539509?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30339827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pires, João</creatorcontrib><creatorcontrib>Kraemer, Julia G.</creatorcontrib><creatorcontrib>Kuenzli, Esther</creatorcontrib><creatorcontrib>Kasraian, Sara</creatorcontrib><creatorcontrib>Tinguely, Regula</creatorcontrib><creatorcontrib>Hatz, Christoph</creatorcontrib><creatorcontrib>Endimiani, Andrea</creatorcontrib><creatorcontrib>Hilty, Markus</creatorcontrib><title>Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study</title><title>Travel medicine and infectious disease</title><addtitle>Travel Med Infect Dis</addtitle><description>Intestinal colonization by extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) has been attributed to travel to high prevalence countries. However, the dynamics of the microbiota changes during ESC-R-Ent colonization and whether there is a particular bacterial composition which is associated with subsequent colonization is unknown.
Forty healthy volunteers living in Switzerland underwent screening before and after a trip to India, and also 3, 6 and 12 months after traveling. Culture-based ESC-R-Ent screening and microbiota analysis based on 16S rRNA amplicon sequencing were performed at all time points.
Prevalence of ESC-R-Ent colonization before traveling was 10% (n = 4), whereas it increased to 76% (n = 31) after the trip. Based on bacterial diversity analyses of the gut microbiota, there were few but significant differences for colonized versus non-colonized individuals. However, an alternative, cluster based analysis revealed that individuals remained in the same cluster over time indicating that neither traveling nor ESC-R-Ent colonization significantly influences bacterial composition. Moreover, none of the found microbiota clusters were significantly associated with subsequent risk of ESC-R-Ent colonization.
Based on their microbiota patterns, every volunteer was at the same risk of ESC-R-Ent colonization while traveling to India. Therefore, other risk factors for ESC-R-Ent colonization are responsible for this phenomenon.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Bacteria</subject><subject>Cephalosporins - pharmacology</subject><subject>Cluster Analysis</subject><subject>Colonization</subject><subject>Composition</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Dynamics</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - genetics</subject><subject>Enterobacteriaceae Infections - epidemiology</subject><subject>ESBL</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Food chains</subject><subject>Gastrointestinal Microbiome</subject><subject>Health care</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>India</subject><subject>Infectious diseases</subject><subject>Intestinal colonization</subject><subject>Intestinal flora</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>MDR bacteria</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>RNA, Ribosomal, 16S - 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Academic</collection><jtitle>Travel medicine and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pires, João</au><au>Kraemer, Julia G.</au><au>Kuenzli, Esther</au><au>Kasraian, Sara</au><au>Tinguely, Regula</au><au>Hatz, Christoph</au><au>Endimiani, Andrea</au><au>Hilty, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study</atitle><jtitle>Travel medicine and infectious disease</jtitle><addtitle>Travel Med Infect Dis</addtitle><date>2019-01</date><risdate>2019</risdate><volume>27</volume><spage>72</spage><epage>80</epage><pages>72-80</pages><issn>1477-8939</issn><eissn>1873-0442</eissn><abstract>Intestinal colonization by extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) has been attributed to travel to high prevalence countries. However, the dynamics of the microbiota changes during ESC-R-Ent colonization and whether there is a particular bacterial composition which is associated with subsequent colonization is unknown.
Forty healthy volunteers living in Switzerland underwent screening before and after a trip to India, and also 3, 6 and 12 months after traveling. Culture-based ESC-R-Ent screening and microbiota analysis based on 16S rRNA amplicon sequencing were performed at all time points.
Prevalence of ESC-R-Ent colonization before traveling was 10% (n = 4), whereas it increased to 76% (n = 31) after the trip. Based on bacterial diversity analyses of the gut microbiota, there were few but significant differences for colonized versus non-colonized individuals. However, an alternative, cluster based analysis revealed that individuals remained in the same cluster over time indicating that neither traveling nor ESC-R-Ent colonization significantly influences bacterial composition. Moreover, none of the found microbiota clusters were significantly associated with subsequent risk of ESC-R-Ent colonization.
Based on their microbiota patterns, every volunteer was at the same risk of ESC-R-Ent colonization while traveling to India. Therefore, other risk factors for ESC-R-Ent colonization are responsible for this phenomenon.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30339827</pmid><doi>10.1016/j.tmaid.2018.10.012</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-8939 |
| ispartof | Travel medicine and infectious disease, 2019-01, Vol.27, p.72-80 |
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| language | eng |
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| subjects | Adult Aged Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Cephalosporins - pharmacology Cluster Analysis Colonization Composition Deoxyribonucleic acid DNA Drug Resistance, Multiple, Bacterial Dynamics Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae Infections - epidemiology ESBL Feces - microbiology Female Food chains Gastrointestinal Microbiome Health care Healthy Volunteers Humans India Infectious diseases Intestinal colonization Intestinal flora Longitudinal Studies Male MDR bacteria Microbiota Middle Aged Prevalence Prospective Studies Risk factors RNA, Ribosomal, 16S - genetics Switzerland Time Factors Travel Travel medicine Travel-Related Illness |
| title | Gut microbiota dynamics in travelers returning from India colonized with extended-spectrum cephalosporin-resistant Enterobacteriaceae: A longitudinal study |
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