Infrasound induces coronary perivascular fibrosis in rats
Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial enviro...
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| Veröffentlicht in: | Cardiovascular pathology 2018-11, Vol.37, p.39-44 |
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| container_title | Cardiovascular pathology |
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| creator | Lousinha, Ana R. Oliveira, Maria João Borrecho, Gonçalo Brito, José Oliveira, Pedro Oliveira de Carvalho, António Freitas, Diamantino P. Águas, Artur Antunes, Eduardo |
| description | Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound ( |
| doi_str_mv | 10.1016/j.carpath.2018.10.004 |
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Adult Wistar rats were divided into three groups: group A (GA)—IFS (<20 Hz, 120 dB)-exposed rats for 28 days treated with dexamethasone; group B (GB)—IFS-exposed rats; group C (GC)—age-matched controls. The midventricle was prepared for observation with an optical microscope using 100× magnification. Thirty-one arterial vessels were selected (GA 8, GB 10, GC 13). The vessel caliber, thickness of the wall, and perivascular dimensions were quantified using image J software. Mann–Whitney and Kruskal–Wallis tests were used to compare the groups for lumen-to-vessel wall (L/W) and vessel wall-to-perivascular tissue (W/P) ratios.
IFS-exposed rats exhibited a prominent perivascular tissue. The median L/W and median W/P ratios were 0.54 and 0.48, 0.66 and 0.49, and 0.71 and 0.68, respectively, in GA, GB, and GC. The W/P ratio was significantly higher in GC compared with IFS-exposed animals (P=.001). The difference was significant between GC and GB (P=.008) but not between GC and GA.
IFS induces coronary perivascular fibrosis that differs under treatment with corticosteroid.
•This study evaluated the morphological changes in rat coronary arteries induced by pure infrasound, created in a laboratory-controlled electroacoustic experiment.•It is the first study assessing the influence of an anti-inflammatory agent on these changes.•The results show that infrasound induces coronary perivascular fibrosis in rats and raise the possibility that an underlying inflammatory mechanism exists.</description><identifier>ISSN: 1054-8807</identifier><identifier>EISSN: 1879-1336</identifier><identifier>DOI: 10.1016/j.carpath.2018.10.004</identifier><identifier>PMID: 30342320</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Coronary arteries ; Coronary Artery Disease - etiology ; Coronary Artery Disease - pathology ; Coronary Artery Disease - prevention & control ; Coronary Vessels - drug effects ; Coronary Vessels - pathology ; Dexamethasone - pharmacology ; Female ; Fibrosis ; Glucocorticoids - pharmacology ; Inflammation ; Infrasound ; Low-frequency noise ; Noise ; Rats, Wistar</subject><ispartof>Cardiovascular pathology, 2018-11, Vol.37, p.39-44</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-dcc23634d0a359068097eaf85d2f0983db2062659e9b19df28576c8f8cd3cb323</citedby><cites>FETCH-LOGICAL-c439t-dcc23634d0a359068097eaf85d2f0983db2062659e9b19df28576c8f8cd3cb323</cites><orcidid>0000-0003-3450-4277 ; 0000-0002-8558-6754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carpath.2018.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30342320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lousinha, Ana</creatorcontrib><creatorcontrib>R. Oliveira, Maria João</creatorcontrib><creatorcontrib>Borrecho, Gonçalo</creatorcontrib><creatorcontrib>Brito, José</creatorcontrib><creatorcontrib>Oliveira, Pedro</creatorcontrib><creatorcontrib>Oliveira de Carvalho, António</creatorcontrib><creatorcontrib>Freitas, Diamantino</creatorcontrib><creatorcontrib>P. Águas, Artur</creatorcontrib><creatorcontrib>Antunes, Eduardo</creatorcontrib><title>Infrasound induces coronary perivascular fibrosis in rats</title><title>Cardiovascular pathology</title><addtitle>Cardiovasc Pathol</addtitle><description>Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound (<20 Hz), whose effects on the heart are unknown. We evaluated the morphological changes induced by IFS in rat coronaries in the presence and absence of dexamethasone.
Adult Wistar rats were divided into three groups: group A (GA)—IFS (<20 Hz, 120 dB)-exposed rats for 28 days treated with dexamethasone; group B (GB)—IFS-exposed rats; group C (GC)—age-matched controls. The midventricle was prepared for observation with an optical microscope using 100× magnification. Thirty-one arterial vessels were selected (GA 8, GB 10, GC 13). The vessel caliber, thickness of the wall, and perivascular dimensions were quantified using image J software. Mann–Whitney and Kruskal–Wallis tests were used to compare the groups for lumen-to-vessel wall (L/W) and vessel wall-to-perivascular tissue (W/P) ratios.
IFS-exposed rats exhibited a prominent perivascular tissue. The median L/W and median W/P ratios were 0.54 and 0.48, 0.66 and 0.49, and 0.71 and 0.68, respectively, in GA, GB, and GC. The W/P ratio was significantly higher in GC compared with IFS-exposed animals (P=.001). The difference was significant between GC and GB (P=.008) but not between GC and GA.
IFS induces coronary perivascular fibrosis that differs under treatment with corticosteroid.
•This study evaluated the morphological changes in rat coronary arteries induced by pure infrasound, created in a laboratory-controlled electroacoustic experiment.•It is the first study assessing the influence of an anti-inflammatory agent on these changes.•The results show that infrasound induces coronary perivascular fibrosis in rats and raise the possibility that an underlying inflammatory mechanism exists.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Coronary arteries</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - prevention & control</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - pathology</subject><subject>Dexamethasone - pharmacology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Glucocorticoids - pharmacology</subject><subject>Inflammation</subject><subject>Infrasound</subject><subject>Low-frequency noise</subject><subject>Noise</subject><subject>Rats, Wistar</subject><issn>1054-8807</issn><issn>1879-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotlZ_grJHL7tOkk02OYmIj0LBi55DNg9M2e7WZLfgvzel1aunGYZvXh9C1xgqDJjfrSuj41aPnxUBLHKtAqhP0ByLRpaYUn6ac2B1KQQ0M3SR0hoARF3X52hGgdaEEpgjuex91GmYeluE3k7GpcIMceh1_C62LoadTmbqdCx8aOOQQspYEfWYLtGZ111yV8e4QB_PT--Pr-Xq7WX5-LAqTU3lWFpjCOW0tqApk8AFyMZpL5glHqSgtiXACWfSyRZL64lgDTfCC2OpaSmhC3R7mLuNw9fk0qg2IRnXdbp3w5QUwYQ2mDPGM8oOqMmXpui82sawyZ8oDGpvTa3V0ZraW9uXs7Xcd3NcMbUbZ_-6fjVl4P4AuPzoLriokgmuN86G6Myo7BD-WfEDuemAFg</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Lousinha, Ana</creator><creator>R. 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Águas, Artur ; Antunes, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-dcc23634d0a359068097eaf85d2f0983db2062659e9b19df28576c8f8cd3cb323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Coronary arteries</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Artery Disease - prevention & control</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - pathology</topic><topic>Dexamethasone - pharmacology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Glucocorticoids - pharmacology</topic><topic>Inflammation</topic><topic>Infrasound</topic><topic>Low-frequency noise</topic><topic>Noise</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lousinha, Ana</creatorcontrib><creatorcontrib>R. Oliveira, Maria João</creatorcontrib><creatorcontrib>Borrecho, Gonçalo</creatorcontrib><creatorcontrib>Brito, José</creatorcontrib><creatorcontrib>Oliveira, Pedro</creatorcontrib><creatorcontrib>Oliveira de Carvalho, António</creatorcontrib><creatorcontrib>Freitas, Diamantino</creatorcontrib><creatorcontrib>P. Águas, Artur</creatorcontrib><creatorcontrib>Antunes, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lousinha, Ana</au><au>R. Oliveira, Maria João</au><au>Borrecho, Gonçalo</au><au>Brito, José</au><au>Oliveira, Pedro</au><au>Oliveira de Carvalho, António</au><au>Freitas, Diamantino</au><au>P. Águas, Artur</au><au>Antunes, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infrasound induces coronary perivascular fibrosis in rats</atitle><jtitle>Cardiovascular pathology</jtitle><addtitle>Cardiovasc Pathol</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>37</volume><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>1054-8807</issn><eissn>1879-1336</eissn><abstract>Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound (<20 Hz), whose effects on the heart are unknown. We evaluated the morphological changes induced by IFS in rat coronaries in the presence and absence of dexamethasone.
Adult Wistar rats were divided into three groups: group A (GA)—IFS (<20 Hz, 120 dB)-exposed rats for 28 days treated with dexamethasone; group B (GB)—IFS-exposed rats; group C (GC)—age-matched controls. The midventricle was prepared for observation with an optical microscope using 100× magnification. Thirty-one arterial vessels were selected (GA 8, GB 10, GC 13). The vessel caliber, thickness of the wall, and perivascular dimensions were quantified using image J software. Mann–Whitney and Kruskal–Wallis tests were used to compare the groups for lumen-to-vessel wall (L/W) and vessel wall-to-perivascular tissue (W/P) ratios.
IFS-exposed rats exhibited a prominent perivascular tissue. The median L/W and median W/P ratios were 0.54 and 0.48, 0.66 and 0.49, and 0.71 and 0.68, respectively, in GA, GB, and GC. The W/P ratio was significantly higher in GC compared with IFS-exposed animals (P=.001). The difference was significant between GC and GB (P=.008) but not between GC and GA.
IFS induces coronary perivascular fibrosis that differs under treatment with corticosteroid.
•This study evaluated the morphological changes in rat coronary arteries induced by pure infrasound, created in a laboratory-controlled electroacoustic experiment.•It is the first study assessing the influence of an anti-inflammatory agent on these changes.•The results show that infrasound induces coronary perivascular fibrosis in rats and raise the possibility that an underlying inflammatory mechanism exists.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30342320</pmid><doi>10.1016/j.carpath.2018.10.004</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3450-4277</orcidid><orcidid>https://orcid.org/0000-0002-8558-6754</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Inflammatory Agents - pharmacology Coronary arteries Coronary Artery Disease - etiology Coronary Artery Disease - pathology Coronary Artery Disease - prevention & control Coronary Vessels - drug effects Coronary Vessels - pathology Dexamethasone - pharmacology Female Fibrosis Glucocorticoids - pharmacology Inflammation Infrasound Low-frequency noise Noise Rats, Wistar |
| title | Infrasound induces coronary perivascular fibrosis in rats |
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