An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. T...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-01, Vol.161, p.48-77
Hauptverfasser:	Wang, Yijie, He, Jun, Liao, Mengya, Hu, Mingxing, Li, Wenzhen, Ouyang, Hongling, Wang, Xin, Ye, Tinghong, Zhang, Yiwen, Ouyang, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Modulators Molecular Structure Protein structures Sirtuin family Sirtuins - antagonists & inhibitors Sirtuins - chemistry Sirtuins - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Therapeutic potential
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