CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

[Display omitted] The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target. Drug side effects and poor pharmacokinetic p...

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Veröffentlicht in:	Biochemical pharmacology 2018-12, Vol.158, p.402-412
Hauptverfasser:	Van Hout, Anneleen, Klarenbeek, Alex, Bobkov, Vladimir, Doijen, Jordi, Arimont, Marta, Zhao, Chunxia, Heukers, Raimond, Rimkunas, Rebecca, de Graaf, Chris, Verrips, Theo, van der Woning, Bas, de Haard, Hans, Rucker, Joseph B., Vermeire, Kurt, Handel, Tracy, Van Loy, Tom, Smit, Martine J., Schols, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemokine receptor CXCR4 Functional selectivity HIV Nanobodies
Online-Zugang:	Volltext
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