Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil
SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil.OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors.DESIGN: One-year cross-sectional survey. Hospitals were included as a convenience sa...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2010-01, Vol.14 (1), p.24-33 |
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| creator | BRITO, R. C MELLO, F. C. Q KRITSKI, A. L ANDRADE, M. K OLIVEIRA, H COSTA, W MATOS, H. J LOURENCO, M. C ROLLA, V. C FONSECA, L RUFFINO NETTO, A |
| description | SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil.OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors.DESIGN: One-year cross-sectional survey. Hospitals were included
as a convenience sample.RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%,
95%CI 14.3-20.5) and 44 (7.4%, 95%CI 5.5-9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4-6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2-8.7) after multivariate
analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7-24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5-8.7), male sex (PR 2.3, 95%CI 1.2-4.4) and dyspnoea (PR 0.3, 95%CI 0.1-0.7).CONCLUSION:
We found high levels of DR- and MDR-TB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless, hospitals should be recognised as a potential source of transmission of resistant
TB strains and urgent measures to avoid nosocomial TB transmission should be taken. |
| format | Article |
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as a convenience sample.RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%,
95%CI 14.3-20.5) and 44 (7.4%, 95%CI 5.5-9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4-6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2-8.7) after multivariate
analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7-24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5-8.7), male sex (PR 2.3, 95%CI 1.2-4.4) and dyspnoea (PR 0.3, 95%CI 0.1-0.7).CONCLUSION:
We found high levels of DR- and MDR-TB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless, hospitals should be recognised as a potential source of transmission of resistant
TB strains and urgent measures to avoid nosocomial TB transmission should be taken.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 20003691</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adolescent ; Adult ; Antitubercular Agents - pharmacology ; Bacterial diseases ; Biological and medical sciences ; Brazil - epidemiology ; Communicable Disease Control - methods ; Cross Infection - prevention & control ; Cross-Sectional Studies ; Drug Resistance ; Drug Resistance, Bacterial ; Epidemiology ; Female ; Hospitals ; Hospitals - statistics & numerical data ; Human bacterial diseases ; Humans ; Infectious diseases ; M. Tuberculosis ; Male ; Mdr-Tb ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Mycobacterium ; Mycobacterium tuberculosis ; Pneumology ; Prevalence ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Sex Factors ; Tuberculosis - drug therapy ; Tuberculosis - epidemiology ; Tuberculosis - transmission ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - transmission</subject><ispartof>The international journal of tuberculosis and lung disease, 2010-01, Vol.14 (1), p.24-33</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22281128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20003691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRITO, R. C</creatorcontrib><creatorcontrib>MELLO, F. C. Q</creatorcontrib><creatorcontrib>KRITSKI, A. L</creatorcontrib><creatorcontrib>ANDRADE, M. K</creatorcontrib><creatorcontrib>OLIVEIRA, H</creatorcontrib><creatorcontrib>COSTA, W</creatorcontrib><creatorcontrib>MATOS, H. J</creatorcontrib><creatorcontrib>LOURENCO, M. C</creatorcontrib><creatorcontrib>ROLLA, V. C</creatorcontrib><creatorcontrib>FONSECA, L</creatorcontrib><creatorcontrib>RUFFINO NETTO, A</creatorcontrib><title>Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil.OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors.DESIGN: One-year cross-sectional survey. Hospitals were included
as a convenience sample.RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%,
95%CI 14.3-20.5) and 44 (7.4%, 95%CI 5.5-9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4-6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2-8.7) after multivariate
analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7-24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5-8.7), male sex (PR 2.3, 95%CI 1.2-4.4) and dyspnoea (PR 0.3, 95%CI 0.1-0.7).CONCLUSION:
We found high levels of DR- and MDR-TB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless, hospitals should be recognised as a potential source of transmission of resistant
TB strains and urgent measures to avoid nosocomial TB transmission should be taken.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Communicable Disease Control - methods</subject><subject>Cross Infection - prevention & control</subject><subject>Cross-Sectional Studies</subject><subject>Drug Resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hospitals</subject><subject>Hospitals - statistics & numerical data</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>M. Tuberculosis</subject><subject>Male</subject><subject>Mdr-Tb</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - transmission</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><subject>Tuberculosis, Multidrug-Resistant - transmission</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctv1DAQh6OqiJbCv1Dl0vZCpJlx_MgR-uChSiAEZ8sbO4tX2WTxA9H-9TjtVj2BD_ZP40-frZmD6hgV8kZ2BIclA8mGSeyOqlcxbgAIEeXL6ogAgIkOj6ubq5DXTXDRx2SmVKe8cqHP41wKtZ_q6P_UP-e488mMD4Vvfq6tqz-byfkwv63fB3Pvx9fVi6EA7s3-PKl-3Fx_v_zY3H758Ony3W3jW-CpQSEFKN4pPgzSWtauoO0Eg2FlUCmwZGxPKEmIVpQLR1YOynBjBaredYqdVBeP3l2Yf2UXk9762LtxLN-Zc9SSMaEQeVfI8_-ShMSQxKI83YN5tXVW74LfmnCnn3pUgLM9YGJvxiGYqffxmSMqL9Iiunrk_LR2UzJ6M-cwlW5on00arfabZSdA0PCwsN0HQG1CWgIvmq__0vRPpmWwy1z1b2wnLEpCUMQ1thy0dYPJY9LJBL2-15Gzvz_Vn28</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>BRITO, R. C</creator><creator>MELLO, F. C. Q</creator><creator>KRITSKI, A. L</creator><creator>ANDRADE, M. K</creator><creator>OLIVEIRA, H</creator><creator>COSTA, W</creator><creator>MATOS, H. J</creator><creator>LOURENCO, M. C</creator><creator>ROLLA, V. C</creator><creator>FONSECA, L</creator><creator>RUFFINO NETTO, A</creator><general>IUATLD</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil</title><author>BRITO, R. C ; MELLO, F. C. Q ; KRITSKI, A. L ; ANDRADE, M. K ; OLIVEIRA, H ; COSTA, W ; MATOS, H. J ; LOURENCO, M. C ; ROLLA, V. 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Tuberculosis</topic><topic>Male</topic><topic>Mdr-Tb</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis</topic><topic>Pneumology</topic><topic>Prevalence</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis - epidemiology</topic><topic>Tuberculosis - transmission</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - epidemiology</topic><topic>Tuberculosis, Multidrug-Resistant - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRITO, R. C</creatorcontrib><creatorcontrib>MELLO, F. C. Q</creatorcontrib><creatorcontrib>KRITSKI, A. L</creatorcontrib><creatorcontrib>ANDRADE, M. K</creatorcontrib><creatorcontrib>OLIVEIRA, H</creatorcontrib><creatorcontrib>COSTA, W</creatorcontrib><creatorcontrib>MATOS, H. J</creatorcontrib><creatorcontrib>LOURENCO, M. C</creatorcontrib><creatorcontrib>ROLLA, V. C</creatorcontrib><creatorcontrib>FONSECA, L</creatorcontrib><creatorcontrib>RUFFINO NETTO, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRITO, R. C</au><au>MELLO, F. C. Q</au><au>KRITSKI, A. L</au><au>ANDRADE, M. K</au><au>OLIVEIRA, H</au><au>COSTA, W</au><au>MATOS, H. J</au><au>LOURENCO, M. C</au><au>ROLLA, V. C</au><au>FONSECA, L</au><au>RUFFINO NETTO, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>14</volume><issue>1</issue><spage>24</spage><epage>33</epage><pages>24-33</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil.OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors.DESIGN: One-year cross-sectional survey. Hospitals were included
as a convenience sample.RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%,
95%CI 14.3-20.5) and 44 (7.4%, 95%CI 5.5-9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4-6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2-8.7) after multivariate
analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7-24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5-8.7), male sex (PR 2.3, 95%CI 1.2-4.4) and dyspnoea (PR 0.3, 95%CI 0.1-0.7).CONCLUSION:
We found high levels of DR- and MDR-TB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless, hospitals should be recognised as a potential source of transmission of resistant
TB strains and urgent measures to avoid nosocomial TB transmission should be taken.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>20003691</pmid><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult Antitubercular Agents - pharmacology Bacterial diseases Biological and medical sciences Brazil - epidemiology Communicable Disease Control - methods Cross Infection - prevention & control Cross-Sectional Studies Drug Resistance Drug Resistance, Bacterial Epidemiology Female Hospitals Hospitals - statistics & numerical data Human bacterial diseases Humans Infectious diseases M. Tuberculosis Male Mdr-Tb Medical sciences Middle Aged Multivariate Analysis Mycobacterium Mycobacterium tuberculosis Pneumology Prevalence Respiratory system : syndromes and miscellaneous diseases Risk Factors Sex Factors Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - transmission Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - transmission |
| title | Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
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