Combination therapy for the treatment of pancreatic cancer through hyaluronic acid‐decorated nanoparticles loaded with quercetin and gemcitabine: A preliminary in vitro study

Combination chemotherapy by means of two or more drugs is prone to suppressing or discouraging the inception of multidrug resistance, exploiting the fact that diverse drugs act in different points of the cellular cycle of amplifying tumor cells. For example, the combination of gemcitabine (GMC) with...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.4959-4969
Hauptverfasser:	Serri, Carla, Quagliariello, Vincenzo, Iaffaioli, Rosario Vincenzo, Fusco, Sabato, Botti, Gerardo, Mayol, Laura, Biondi, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Biodegradability Biodegradation Biotechnology Cancer Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy CD44 CD44 antigen Cell Line, Tumor Cell migration Cell Survival - drug effects Chemotherapy Cytotoxicity Decoration Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Carriers - pharmacology Drug resistance Drug Synergism Drugs Gemcitabine Glycolic acid Humans Hyaluronic acid Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacology Inflammation Interleukins Lipopolysaccharides Metastases Multidrug resistance Nanoparticles Nanoparticles - administration & dosage Pancreas Pancreatic cancer Pancreatic Neoplasms - drug therapy Quercetin Quercetin - pharmacology Synergistic effect Toxicity Tumor cell lines Tumor cells Tumors
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