A Comparison of the Pharmacokinetics and Tolerability of Riluzole after Repeat Dose Administration in Healthy Elderly and Young Volunteers

The pharmacokinetics and tolerability of the novel antiexcitatory agent, riluzole, were compared in 18 healthy elderly and 18 healthy gender‐ and weight‐matched young volunteers. All participants received riluzole 50 mg twice daily (the recommended dosage for patients with amyotrophic lateral sclero...

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Veröffentlicht in:	Journal of clinical pharmacology 1999-05, Vol.39 (5), p.480-486
Hauptverfasser:	Liboux, Aimé Le, Cachia, Jean-Paul, Kirkesseli, Stéphane, Gautier, Jean-Yves, Guimart, Colette, Montay, Guy, Peeters, Pierre A. M., Groen, Edwin, Jonkman, Jan H. G., Wemer, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Aging - metabolism Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - adverse effects Excitatory Amino Acid Antagonists - pharmacokinetics Female Humans Male Medical sciences Neuropharmacology Neuroprotective Agents - administration & dosage Neuroprotective Agents - adverse effects Neuroprotective Agents - pharmacokinetics Pharmacology. Drug treatments Riluzole - administration & dosage Riluzole - adverse effects Riluzole - pharmacokinetics
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