Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria

Objective Chlorproguanil (CPG)-dapsone (DDS)-artesunate was in development for the treatment of uncomplicated Plasmodium falciparum malaria. The pharmacokinetics of CPG, DDS, artesunate and their metabolites chlorcycloguanil (CCG), monoacetyl dapsone (MADDS) and dihydroartemisinin (DHA) were investi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of clinical pharmacology 2009-10, Vol.65 (10), p.977-987
Hauptverfasser:	Miller, Ann K, Bandyopadhyay, Nibedita, Wootton, Daniel G, Duparc, Stephan, Kirby, Paula L, Winstanley, Peter A, Ward, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimalarials - administration & dosage Antimalarials - blood Antimalarials - pharmacokinetics Area Under Curve Artemisinins - administration & dosage Artemisinins - blood Artemisinins - pharmacokinetics Bioavailability Biological and medical sciences Biomedical and Life Sciences Biomedicine Clinical outcomes Clinical trials Dapsone - administration & dosage Dapsone - blood Dapsone - pharmacokinetics Dose-Response Relationship, Drug Drug Combinations Drug Synergism Drug therapy Drug Therapy, Combination Female Gambia Human protozoal diseases Humans Infectious diseases Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - metabolism Malawi Male Medical sciences Metabolites Middle Aged Parasitic diseases Parasitic Sensitivity Tests Pharmacokinetics and Disposition Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Plasmodium falciparum Proguanil - administration & dosage Proguanil - analogs & derivatives Proguanil - blood Proguanil - pharmacokinetics Protozoal diseases Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!