Anticancer activity of two novel ruthenium compounds in gastric cancer cells

Ruthenium (II) complexes are promising anticancer molecules due its pharmacological properties and selectivity to cells tumor. The aim of this work was to study the cytotoxic activity, and apoptosis induction of two new ruthenium complexes on a human gastric cancer cell line. Two ruthenium(II) compl...

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Veröffentlicht in:	Life sciences (1973) 2018-11, Vol.213, p.57-65
Hauptverfasser:	Ramírez-Rivera, S., Pizarro, S., Gallardo, M., Gajardo, F., Delgadillo, A., De La Fuente-Ortega, E., MacDonnell, F.M., Bernal, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - pharmacology Antitumor activity Antitumor agents Apoptosis Apoptosis - drug effects Cancer Caspase Cell Line, Tumor - drug effects Cell Survival - drug effects Chemical compounds Cisplatin Cisplatin - pharmacology Confocal microscopy Cytotoxicity Dose-Response Relationship, Drug Gastric cancer Gene expression Genes Humans Microscopy Pharmacology Polymerase chain reaction RT-qPCR analysis Ru(II) complexes Ruthenium Ruthenium - pharmacology Ruthenium - therapeutic use Ruthenium compounds Ruthenium Compounds - pharmacology Ruthenium Compounds - therapeutic use Selectivity Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Structure-Activity Relationship
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