Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches
Objectives The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants. Materials and methods This placebo-controlled study in...
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| Veröffentlicht in: | Clinical oral investigations 2019-06, Vol.23 (6), p.2637-2649 |
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| container_title | Clinical oral investigations |
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| creator | Kothari, Simple Futarmal Shimosaka, Michiharu Iida, Takashi Komiyama, Osamu Shibutani, Koh Svensson, Peter Baad-Hansen, Lene |
| description | Objectives
The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants.
Materials and methods
This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (
n
= 15) and infraorbital (
n
= 15) nerve blocks and during control (saline) sessions. Perceived numbness, temperature changes, and perceptual distortion were also measured at all time points during the nerve block and control sessions. Differences in outcome parameters between the sessions and time points were analyzed using analyses of variance and McNemar’s tests.
Results
There was a significant degree of sensory loss to most QST and all QualST parameters, with significant numbness and increased perceived size at the injection site 10 min and 2 h after the nerve blocks compared with saline (
P
|
| doi_str_mv | 10.1007/s00784-018-2695-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2121493985</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2121493985</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-975f57533f9b4df41066b97139310f49ca6d7c4d828484e3ba07e6ea0b9da0153</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS1ERUvhAdggS2zYhPovcbxEFX9SJVQJ1pZjj3tdEqf1JKD7Bjw2Tm8pElI3tsf-zpmRDyGvOHvHGdNnWJdeNYz3jehM26gn5IQr2TVSa_707iyazvT8mDxHvGaMq07LZ-RYMim0UeaE_L5cXV7S4pb0E6jLgd6ubnyoEQFxgrzQOVKEjHPZU79z-QqQphxWD4EOezrO3o1VDrjsYEke6VCvfmyq5ddMQ4oRymazlHQFU8qVzlBqi6G47HeAL8hRdCPCy_v9lHz_-OHb-efm4uunL-fvLxovtVgao9vY6lbKaAYVouKs6wajuTSSs6iMd13QXoVe9KpXIAfHNHTg2GCCY7yVp-TtwfemzLdrnddOCT2MYx1-XtEKLrgy0vQb-uY_9HpeSx39jmKdNkL2leIHypcZsUC0NyVNruwtZ3aLyR5isjUmu8VkVdW8vndehwnCg-JvLhUQBwDrU_3s8q_1465_AHAkn1o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2120679238</pqid></control><display><type>article</type><title>Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches</title><source>MEDLINE</source><source>SpringerLink</source><creator>Kothari, Simple Futarmal ; Shimosaka, Michiharu ; Iida, Takashi ; Komiyama, Osamu ; Shibutani, Koh ; Svensson, Peter ; Baad-Hansen, Lene</creator><creatorcontrib>Kothari, Simple Futarmal ; Shimosaka, Michiharu ; Iida, Takashi ; Komiyama, Osamu ; Shibutani, Koh ; Svensson, Peter ; Baad-Hansen, Lene</creatorcontrib><description>Objectives
The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants.
Materials and methods
This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (
n
= 15) and infraorbital (
n
= 15) nerve blocks and during control (saline) sessions. Perceived numbness, temperature changes, and perceptual distortion were also measured at all time points during the nerve block and control sessions. Differences in outcome parameters between the sessions and time points were analyzed using analyses of variance and McNemar’s tests.
Results
There was a significant degree of sensory loss to most QST and all QualST parameters, with significant numbness and increased perceived size at the injection site 10 min and 2 h after the nerve blocks compared with saline (
P
< 0.030) and the baseline (
P
< 0.042). Two hours after the nerve blocks, the sensitivity was significantly closer to baseline than after 10 min to most of the QST parameters (
P
< 0.011).
Conclusions
QST and QualST revealed that the nerve blocks in the orofacial region resulted in complete or partial blockade of afferent nerve fibers mediating thermal and mechanical function for more than 2 h with significant numbness and perceptual distortion.
Clinical relevance
Both QST and QualST can provide information on the degree of blockade of afferent nerve fibers after nerve blocks in the orofacial region.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-018-2695-4</identifier><identifier>PMID: 30327949</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Anesthetics ; Anesthetics, Local ; Dentistry ; Face ; Female ; Fibers ; Humans ; Injections ; Local anesthesia ; Local anesthetics ; Male ; Mechanical properties ; Medicine ; Nerve Block ; Original Article ; Sensation ; Sensory neurons ; Temperature perception ; Thermosensing ; Trigeminal nerve ; Trigeminal Nerve - drug effects ; Young Adult</subject><ispartof>Clinical oral investigations, 2019-06, Vol.23 (6), p.2637-2649</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-975f57533f9b4df41066b97139310f49ca6d7c4d828484e3ba07e6ea0b9da0153</citedby><cites>FETCH-LOGICAL-c372t-975f57533f9b4df41066b97139310f49ca6d7c4d828484e3ba07e6ea0b9da0153</cites><orcidid>0000-0001-8043-2927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-018-2695-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-018-2695-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30327949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kothari, Simple Futarmal</creatorcontrib><creatorcontrib>Shimosaka, Michiharu</creatorcontrib><creatorcontrib>Iida, Takashi</creatorcontrib><creatorcontrib>Komiyama, Osamu</creatorcontrib><creatorcontrib>Shibutani, Koh</creatorcontrib><creatorcontrib>Svensson, Peter</creatorcontrib><creatorcontrib>Baad-Hansen, Lene</creatorcontrib><title>Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants.
Materials and methods
This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (
n
= 15) and infraorbital (
n
= 15) nerve blocks and during control (saline) sessions. Perceived numbness, temperature changes, and perceptual distortion were also measured at all time points during the nerve block and control sessions. Differences in outcome parameters between the sessions and time points were analyzed using analyses of variance and McNemar’s tests.
Results
There was a significant degree of sensory loss to most QST and all QualST parameters, with significant numbness and increased perceived size at the injection site 10 min and 2 h after the nerve blocks compared with saline (
P
< 0.030) and the baseline (
P
< 0.042). Two hours after the nerve blocks, the sensitivity was significantly closer to baseline than after 10 min to most of the QST parameters (
P
< 0.011).
Conclusions
QST and QualST revealed that the nerve blocks in the orofacial region resulted in complete or partial blockade of afferent nerve fibers mediating thermal and mechanical function for more than 2 h with significant numbness and perceptual distortion.
Clinical relevance
Both QST and QualST can provide information on the degree of blockade of afferent nerve fibers after nerve blocks in the orofacial region.</description><subject>Adult</subject><subject>Anesthetics</subject><subject>Anesthetics, Local</subject><subject>Dentistry</subject><subject>Face</subject><subject>Female</subject><subject>Fibers</subject><subject>Humans</subject><subject>Injections</subject><subject>Local anesthesia</subject><subject>Local anesthetics</subject><subject>Male</subject><subject>Mechanical properties</subject><subject>Medicine</subject><subject>Nerve Block</subject><subject>Original Article</subject><subject>Sensation</subject><subject>Sensory neurons</subject><subject>Temperature perception</subject><subject>Thermosensing</subject><subject>Trigeminal nerve</subject><subject>Trigeminal Nerve - drug effects</subject><subject>Young Adult</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1TAQhS1ERUvhAdggS2zYhPovcbxEFX9SJVQJ1pZjj3tdEqf1JKD7Bjw2Tm8pElI3tsf-zpmRDyGvOHvHGdNnWJdeNYz3jehM26gn5IQr2TVSa_707iyazvT8mDxHvGaMq07LZ-RYMim0UeaE_L5cXV7S4pb0E6jLgd6ubnyoEQFxgrzQOVKEjHPZU79z-QqQphxWD4EOezrO3o1VDrjsYEke6VCvfmyq5ddMQ4oRymazlHQFU8qVzlBqi6G47HeAL8hRdCPCy_v9lHz_-OHb-efm4uunL-fvLxovtVgao9vY6lbKaAYVouKs6wajuTSSs6iMd13QXoVe9KpXIAfHNHTg2GCCY7yVp-TtwfemzLdrnddOCT2MYx1-XtEKLrgy0vQb-uY_9HpeSx39jmKdNkL2leIHypcZsUC0NyVNruwtZ3aLyR5isjUmu8VkVdW8vndehwnCg-JvLhUQBwDrU_3s8q_1465_AHAkn1o</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Kothari, Simple Futarmal</creator><creator>Shimosaka, Michiharu</creator><creator>Iida, Takashi</creator><creator>Komiyama, Osamu</creator><creator>Shibutani, Koh</creator><creator>Svensson, Peter</creator><creator>Baad-Hansen, Lene</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8043-2927</orcidid></search><sort><creationdate>20190601</creationdate><title>Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches</title><author>Kothari, Simple Futarmal ; Shimosaka, Michiharu ; Iida, Takashi ; Komiyama, Osamu ; Shibutani, Koh ; Svensson, Peter ; Baad-Hansen, Lene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-975f57533f9b4df41066b97139310f49ca6d7c4d828484e3ba07e6ea0b9da0153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Anesthetics</topic><topic>Anesthetics, Local</topic><topic>Dentistry</topic><topic>Face</topic><topic>Female</topic><topic>Fibers</topic><topic>Humans</topic><topic>Injections</topic><topic>Local anesthesia</topic><topic>Local anesthetics</topic><topic>Male</topic><topic>Mechanical properties</topic><topic>Medicine</topic><topic>Nerve Block</topic><topic>Original Article</topic><topic>Sensation</topic><topic>Sensory neurons</topic><topic>Temperature perception</topic><topic>Thermosensing</topic><topic>Trigeminal nerve</topic><topic>Trigeminal Nerve - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kothari, Simple Futarmal</creatorcontrib><creatorcontrib>Shimosaka, Michiharu</creatorcontrib><creatorcontrib>Iida, Takashi</creatorcontrib><creatorcontrib>Komiyama, Osamu</creatorcontrib><creatorcontrib>Shibutani, Koh</creatorcontrib><creatorcontrib>Svensson, Peter</creatorcontrib><creatorcontrib>Baad-Hansen, Lene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest Medical & Health Databases)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kothari, Simple Futarmal</au><au>Shimosaka, Michiharu</au><au>Iida, Takashi</au><au>Komiyama, Osamu</au><au>Shibutani, Koh</au><au>Svensson, Peter</au><au>Baad-Hansen, Lene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>23</volume><issue>6</issue><spage>2637</spage><epage>2649</epage><pages>2637-2649</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
The aims were to use different techniques to assess the degree of sensory changes and magnitude of perceived size changes in the facial region induced by nerve blocks of two different trigeminal nerve branches in healthy participants.
Materials and methods
This placebo-controlled study included 30 healthy volunteers. The participants underwent quantitative and qualitative sensory testing (QST and QualST) thrice: before, 10 min, and 2 h after mental (
n
= 15) and infraorbital (
n
= 15) nerve blocks and during control (saline) sessions. Perceived numbness, temperature changes, and perceptual distortion were also measured at all time points during the nerve block and control sessions. Differences in outcome parameters between the sessions and time points were analyzed using analyses of variance and McNemar’s tests.
Results
There was a significant degree of sensory loss to most QST and all QualST parameters, with significant numbness and increased perceived size at the injection site 10 min and 2 h after the nerve blocks compared with saline (
P
< 0.030) and the baseline (
P
< 0.042). Two hours after the nerve blocks, the sensitivity was significantly closer to baseline than after 10 min to most of the QST parameters (
P
< 0.011).
Conclusions
QST and QualST revealed that the nerve blocks in the orofacial region resulted in complete or partial blockade of afferent nerve fibers mediating thermal and mechanical function for more than 2 h with significant numbness and perceptual distortion.
Clinical relevance
Both QST and QualST can provide information on the degree of blockade of afferent nerve fibers after nerve blocks in the orofacial region.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30327949</pmid><doi>10.1007/s00784-018-2695-4</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8043-2927</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2019-06, Vol.23 (6), p.2637-2649 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2121493985 |
| source | MEDLINE; SpringerLink |
| subjects | Adult Anesthetics Anesthetics, Local Dentistry Face Female Fibers Humans Injections Local anesthesia Local anesthetics Male Mechanical properties Medicine Nerve Block Original Article Sensation Sensory neurons Temperature perception Thermosensing Trigeminal nerve Trigeminal Nerve - drug effects Young Adult |
| title | Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches |
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