Improving pregnancy outcomes in humans through studies in sheep
Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of pr...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2018-12, Vol.315 (6), p.R1123-R1153 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Morrison, Janna L Berry, Mary J Botting, Kimberley J Darby, Jack R T Frasch, Martin G Gatford, Kathryn L Giussani, Dino A Gray, Clint L Harding, Richard Herrera, Emilio A Kemp, Matthew W Lock, Mitchell C McMillen, I Caroline Moss, Timothy J Musk, Gabrielle C Oliver, Mark H Regnault, Timothy R H Roberts, Claire T Soo, Jia Yin Tellam, Ross L |
| description | Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus. |
| doi_str_mv | 10.1152/ajpregu.00391.2017 |
| format | Article |
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Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00391.2017</identifier><identifier>PMID: 30325659</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animal models ; Animals ; Dehydrogenases ; Design of experiments ; Disease Models, Animal ; Etiology ; Experimental design ; Fatty acids ; Female ; Fetus - metabolism ; Fetuses ; Heatstroke ; Hogs ; Humans ; Maternal-Fetal Exchange - physiology ; Metabolism ; Ovis aries ; Placenta ; Placenta - metabolism ; Pregnancy ; Pregnancy Outcome ; Pregnancy, Animal ; Sheep ; Sheep - physiology ; Skeletal system ; Translation</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2018-12, Vol.315 (6), p.R1123-R1153</ispartof><rights>Copyright American Physiological Society Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c64bce271989497ce9c58a97f27bf4e96a962516d0ac04f4106e7fac02f1dff83</citedby><cites>FETCH-LOGICAL-c375t-c64bce271989497ce9c58a97f27bf4e96a962516d0ac04f4106e7fac02f1dff83</cites><orcidid>0000-0001-9798-6790 ; 0000-0001-5964-1687 ; 0000-0002-8602-8519 ; 0000-0002-2823-3004 ; 0000-0002-3594-1455 ; 0000-0002-9408-4027 ; 0000-0001-7114-3920 ; 0000-0003-2353-1640 ; 0000-0003-3159-6321 ; 0000-0002-9250-2192</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30325659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morrison, Janna L</creatorcontrib><creatorcontrib>Berry, Mary J</creatorcontrib><creatorcontrib>Botting, Kimberley J</creatorcontrib><creatorcontrib>Darby, Jack R T</creatorcontrib><creatorcontrib>Frasch, Martin G</creatorcontrib><creatorcontrib>Gatford, Kathryn L</creatorcontrib><creatorcontrib>Giussani, Dino A</creatorcontrib><creatorcontrib>Gray, Clint L</creatorcontrib><creatorcontrib>Harding, Richard</creatorcontrib><creatorcontrib>Herrera, Emilio A</creatorcontrib><creatorcontrib>Kemp, Matthew W</creatorcontrib><creatorcontrib>Lock, Mitchell C</creatorcontrib><creatorcontrib>McMillen, I Caroline</creatorcontrib><creatorcontrib>Moss, Timothy J</creatorcontrib><creatorcontrib>Musk, Gabrielle C</creatorcontrib><creatorcontrib>Oliver, Mark H</creatorcontrib><creatorcontrib>Regnault, Timothy R H</creatorcontrib><creatorcontrib>Roberts, Claire T</creatorcontrib><creatorcontrib>Soo, Jia Yin</creatorcontrib><creatorcontrib>Tellam, Ross L</creatorcontrib><title>Improving pregnancy outcomes in humans through studies in sheep</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.</description><subject>Animal models</subject><subject>Animals</subject><subject>Dehydrogenases</subject><subject>Design of experiments</subject><subject>Disease Models, Animal</subject><subject>Etiology</subject><subject>Experimental design</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fetuses</subject><subject>Heatstroke</subject><subject>Hogs</subject><subject>Humans</subject><subject>Maternal-Fetal Exchange - physiology</subject><subject>Metabolism</subject><subject>Ovis aries</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy, Animal</subject><subject>Sheep</subject><subject>Sheep - physiology</subject><subject>Skeletal system</subject><subject>Translation</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEQhoMotlb_gAdZ8OJl6-Rjs81JpPhRKHjRc0izSXdLN7smG6H_3tRWD55mYJ55mXkQusYwxbgg92rTe7OOUwAq8JQALk_QOA1IjpmAUzQGymnOMRYjdBHCBgAYZfQcjShQUvBCjNHDou1999W4dbYPc8rpXdbFQXetCVnjsjq2yoVsqH0X13UWhlg1h0mojekv0ZlV22CujnWCPp6f3uev-fLtZTF_XOaalsWQa85W2pASi5lgotRG6GKmRGlJubLMCK4EJwXmFSgNzDIM3JQ29cTiytoZnaC7Q2669jOaMMi2Cdpst8qZLgZJMElPEw44obf_0E0XvUvXJYoDLZIESBQ5UNp3IXhjZe-bVvmdxCD3euVRr_zRK_d609LNMTquWlP9rfz6pN_4IXcD</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Morrison, Janna L</creator><creator>Berry, Mary J</creator><creator>Botting, Kimberley J</creator><creator>Darby, Jack R T</creator><creator>Frasch, Martin G</creator><creator>Gatford, Kathryn L</creator><creator>Giussani, Dino A</creator><creator>Gray, Clint L</creator><creator>Harding, Richard</creator><creator>Herrera, Emilio A</creator><creator>Kemp, Matthew W</creator><creator>Lock, Mitchell C</creator><creator>McMillen, I Caroline</creator><creator>Moss, Timothy J</creator><creator>Musk, Gabrielle C</creator><creator>Oliver, Mark H</creator><creator>Regnault, Timothy R H</creator><creator>Roberts, Claire T</creator><creator>Soo, Jia Yin</creator><creator>Tellam, Ross L</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9798-6790</orcidid><orcidid>https://orcid.org/0000-0001-5964-1687</orcidid><orcidid>https://orcid.org/0000-0002-8602-8519</orcidid><orcidid>https://orcid.org/0000-0002-2823-3004</orcidid><orcidid>https://orcid.org/0000-0002-3594-1455</orcidid><orcidid>https://orcid.org/0000-0002-9408-4027</orcidid><orcidid>https://orcid.org/0000-0001-7114-3920</orcidid><orcidid>https://orcid.org/0000-0003-2353-1640</orcidid><orcidid>https://orcid.org/0000-0003-3159-6321</orcidid><orcidid>https://orcid.org/0000-0002-9250-2192</orcidid></search><sort><creationdate>20181201</creationdate><title>Improving pregnancy outcomes in humans through studies in sheep</title><author>Morrison, Janna L ; 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Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>315</volume><issue>6</issue><spage>R1123</spage><epage>R1153</epage><pages>R1123-R1153</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>30325659</pmid><doi>10.1152/ajpregu.00391.2017</doi><orcidid>https://orcid.org/0000-0001-9798-6790</orcidid><orcidid>https://orcid.org/0000-0001-5964-1687</orcidid><orcidid>https://orcid.org/0000-0002-8602-8519</orcidid><orcidid>https://orcid.org/0000-0002-2823-3004</orcidid><orcidid>https://orcid.org/0000-0002-3594-1455</orcidid><orcidid>https://orcid.org/0000-0002-9408-4027</orcidid><orcidid>https://orcid.org/0000-0001-7114-3920</orcidid><orcidid>https://orcid.org/0000-0003-2353-1640</orcidid><orcidid>https://orcid.org/0000-0003-3159-6321</orcidid><orcidid>https://orcid.org/0000-0002-9250-2192</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2018-12, Vol.315 (6), p.R1123-R1153 |
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| subjects | Animal models Animals Dehydrogenases Design of experiments Disease Models, Animal Etiology Experimental design Fatty acids Female Fetus - metabolism Fetuses Heatstroke Hogs Humans Maternal-Fetal Exchange - physiology Metabolism Ovis aries Placenta Placenta - metabolism Pregnancy Pregnancy Outcome Pregnancy, Animal Sheep Sheep - physiology Skeletal system Translation |
| title | Improving pregnancy outcomes in humans through studies in sheep |
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