Developmental toxicity of brominated flame retardants, tetrabromobisphenol A and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from mid-gestation through lactation

To evaluate developmental exposure effects of two brominated flame retardants, tetrabromobisphenol A (TBBPA) and 1,2,5,6,9,10-hexabromocyclododecane (HBCD), pregnant Sprague–Dawley rats were administered either chemical at doses of 100, 1000 or 10,000 ppm in a soy-free diet from gestation day 10 unt...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2009-12, Vol.28 (4), p.456-467
Hauptverfasser:	Saegusa, Yukie, Fujimoto, Hitoshi, Woo, Gye-Hyeong, Inoue, Kaoru, Takahashi, Miwa, Mitsumori, Kunitoshi, Hirose, Masao, Nishikawa, Akiyoshi, Shibutani, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,5,6,9,10-Hexabromocyclododecane (HBCD) Animals Biological and medical sciences Brain retardation Brominated flame retardants (BFRs) Developmental toxicity Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Female Fetus - drug effects Flame Retardants - toxicity Fundamental and applied biological sciences. Psychology Hydrocarbons, Brominated - toxicity Maternal Exposure Medical sciences No-Observed-Adverse-Effect Level Organ Size - drug effects Polybrominated Biphenyls - toxicity Pregnancy Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Sprague-Dawley Teratology. Teratogens Tetrabromobisphenol A (TBBPA) Thyroid Gland - drug effects Thyroid Gland - pathology Thyroid hormones Thyrotropin - blood Toxicology Triiodothyronine - blood
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