Correlation between the Trofile super(+) test and virological response to a short-term maraviroc exposure in HIV-infected patients

Objectives The current validated assay to determine tropism of HIV variants is Trofile super(+), which has some limitations. The aim of this work was to correlate the virological response to a short-term maraviroc exposure with Trofile super(+).Methods From 1 July 2008 to 1 March 2009, 34 consecutive HIV-infected patients with detectable viral load during the last 6 months began an 8 day exposure to maraviroc (MCT group); six HIV-infected patients without antiretroviral therapy received no treatment (control group). Plasma viral load was evaluated on days 0, 2, 5 and 8. Baseline Trofile super(+) was performed in MCT group patients. The maraviroc clinical test (MCT) was considered positive if viral load was undetectable (