Topical Review: Animal Models of Germinal Matrix Hemorrhage
Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, in...
Gespeichert in:
Veröffentlicht in: | Journal of Child Neurology 2006-05, Vol.21 (5), p.365-371 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 371 |
---|---|
container_issue | 5 |
container_start_page | 365 |
container_title | Journal of Child Neurology |
container_volume | 21 |
creator | Balasubramaniam, Janani Del Bigio, Marc R. |
description | Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral palsy, seizures, and learning disabilities. Understanding the causative factors and the pathogenesis of subsequent brain damage is important if germinal matrix hemorrhage is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. A number of animal species, including mice, rats, rabbits, sheep, pigs, dogs, cats, and primates, have been used to model germinal matrix hemorrhage. This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage. (J Child Neurol 2006;21:365—371; DOI 10.2310/7010.2006.00074). |
doi_str_mv | 10.1177/08830738060210050201 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21209890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_08830738060210050201</sage_id><sourcerecordid>21209890</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1691-6effd53e3b7a75013c0f8f5ca36109bf41b75f86ee86c586217af263db665e9f3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWKv_wMOevK3OJM3H6qkU2woVQeo5ZLcT3bLb1KT149-7Sz2Kp2GG5x14XsYuEa4Rtb4BYwRoYUABRwAJHPCIDVCDyQ034pgNeiTvmVN2ltIaAIwsYMDulmFbV67Jnumjps_bbLyp2259DCtqUhZ8NqPY1pv-5Hax_srm1IYY39wrnbMT75pEF79zyF6m98vJPF88zR4m40VeoSowV-T9SgoSpXZaAooKvPGyckIhFKUfYamlN4rIqEoaxVE7z5VYlUpJKrwYsqvD320M73tKO9vWqaKmcRsK-2Q5cihMAR04OoBVDClF8nYbO5v4bRFs35T9q6kuhodY6qTsOuxjp5v-z_wAImlnxw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21209890</pqid></control><display><type>article</type><title>Topical Review: Animal Models of Germinal Matrix Hemorrhage</title><source>Access via SAGE</source><creator>Balasubramaniam, Janani ; Del Bigio, Marc R.</creator><creatorcontrib>Balasubramaniam, Janani ; Del Bigio, Marc R.</creatorcontrib><description>Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral palsy, seizures, and learning disabilities. Understanding the causative factors and the pathogenesis of subsequent brain damage is important if germinal matrix hemorrhage is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. A number of animal species, including mice, rats, rabbits, sheep, pigs, dogs, cats, and primates, have been used to model germinal matrix hemorrhage. This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage. (J Child Neurol 2006;21:365—371; DOI 10.2310/7010.2006.00074).</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/08830738060210050201</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Primates</subject><ispartof>Journal of Child Neurology, 2006-05, Vol.21 (5), p.365-371</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1691-6effd53e3b7a75013c0f8f5ca36109bf41b75f86ee86c586217af263db665e9f3</citedby><cites>FETCH-LOGICAL-c1691-6effd53e3b7a75013c0f8f5ca36109bf41b75f86ee86c586217af263db665e9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/08830738060210050201$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/08830738060210050201$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,780,784,792,21819,27922,27924,27925,43621,43622</link.rule.ids></links><search><creatorcontrib>Balasubramaniam, Janani</creatorcontrib><creatorcontrib>Del Bigio, Marc R.</creatorcontrib><title>Topical Review: Animal Models of Germinal Matrix Hemorrhage</title><title>Journal of Child Neurology</title><description>Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral palsy, seizures, and learning disabilities. Understanding the causative factors and the pathogenesis of subsequent brain damage is important if germinal matrix hemorrhage is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. A number of animal species, including mice, rats, rabbits, sheep, pigs, dogs, cats, and primates, have been used to model germinal matrix hemorrhage. This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage. (J Child Neurol 2006;21:365—371; DOI 10.2310/7010.2006.00074).</description><subject>Primates</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKv_wMOevK3OJM3H6qkU2woVQeo5ZLcT3bLb1KT149-7Sz2Kp2GG5x14XsYuEa4Rtb4BYwRoYUABRwAJHPCIDVCDyQ034pgNeiTvmVN2ltIaAIwsYMDulmFbV67Jnumjps_bbLyp2259DCtqUhZ8NqPY1pv-5Hax_srm1IYY39wrnbMT75pEF79zyF6m98vJPF88zR4m40VeoSowV-T9SgoSpXZaAooKvPGyckIhFKUfYamlN4rIqEoaxVE7z5VYlUpJKrwYsqvD320M73tKO9vWqaKmcRsK-2Q5cihMAR04OoBVDClF8nYbO5v4bRFs35T9q6kuhodY6qTsOuxjp5v-z_wAImlnxw</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Balasubramaniam, Janani</creator><creator>Del Bigio, Marc R.</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>200605</creationdate><title>Topical Review: Animal Models of Germinal Matrix Hemorrhage</title><author>Balasubramaniam, Janani ; Del Bigio, Marc R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1691-6effd53e3b7a75013c0f8f5ca36109bf41b75f86ee86c586217af263db665e9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Primates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balasubramaniam, Janani</creatorcontrib><creatorcontrib>Del Bigio, Marc R.</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Child Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balasubramaniam, Janani</au><au>Del Bigio, Marc R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical Review: Animal Models of Germinal Matrix Hemorrhage</atitle><jtitle>Journal of Child Neurology</jtitle><date>2006-05</date><risdate>2006</risdate><volume>21</volume><issue>5</issue><spage>365</spage><epage>371</epage><pages>365-371</pages><issn>0883-0738</issn><eissn>1708-8283</eissn><abstract>Germinal matrix hemorrhage refers to bleeding that arises from the subependymal (or periventricular) germinal region of the immature brain. Clinical studies have shown that infants who experience germinal matrix hemorrhage can develop hydrocephalus or suffer from long-term neurologic dysfunction, including cerebral palsy, seizures, and learning disabilities. Understanding the causative factors and the pathogenesis of subsequent brain damage is important if germinal matrix hemorrhage is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. A number of animal species, including mice, rats, rabbits, sheep, pigs, dogs, cats, and primates, have been used to model germinal matrix hemorrhage. This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage. (J Child Neurol 2006;21:365—371; DOI 10.2310/7010.2006.00074).</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><doi>10.1177/08830738060210050201</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0883-0738 |
ispartof | Journal of Child Neurology, 2006-05, Vol.21 (5), p.365-371 |
issn | 0883-0738 1708-8283 |
language | eng |
recordid | cdi_proquest_miscellaneous_21209890 |
source | Access via SAGE |
subjects | Primates |
title | Topical Review: Animal Models of Germinal Matrix Hemorrhage |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T05%3A03%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Topical%20Review:%20Animal%20Models%20of%20Germinal%20Matrix%20Hemorrhage&rft.jtitle=Journal%20of%20Child%20Neurology&rft.au=Balasubramaniam,%20Janani&rft.date=2006-05&rft.volume=21&rft.issue=5&rft.spage=365&rft.epage=371&rft.pages=365-371&rft.issn=0883-0738&rft.eissn=1708-8283&rft_id=info:doi/10.1177/08830738060210050201&rft_dat=%3Cproquest_cross%3E21209890%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21209890&rft_id=info:pmid/&rft_sage_id=10.1177_08830738060210050201&rfr_iscdi=true |