Pharmacokinetics of an Oral Once-a-Day Controlled-Release Oxybutynin Formulation Compared with Immediate-Release Oxybutynin

Oxybutynin is used for the treatment of urge urinary incontinence. In this randomized, open‐label, two‐way crossover, multiple‐dose study, the pharmacokinetics of a once‐daily, controlled‐release formulation, OROS® oxybutynin chloride, was compared with that of immediate‐release (IR) oxybutynin (Dit...

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Veröffentlicht in:	Journal of clinical pharmacology 1999-03, Vol.39 (3), p.289-296
Hauptverfasser:	Gupta, Suneel K., Sathyan, Gayatri
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Area Under Curve Biological and medical sciences Cholinergic Antagonists - adverse effects Cholinergic Antagonists - pharmacokinetics Cholinergic Antagonists - therapeutic use Circadian Rhythm - physiology Cross-Over Studies Delayed-Action Preparations Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Mandelic Acids - adverse effects Mandelic Acids - blood Mandelic Acids - pharmacokinetics Mandelic Acids - therapeutic use Medical sciences Metabolic Clearance Rate Middle Aged Pharmacology. Drug treatments Urinary Incontinence - drug therapy Urinary system Xerostomia - chemically induced
Online-Zugang:	Volltext
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