Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients
The role of human papilloma virus (HPV) in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) is well documented, as is the excellent prognosis of patients with HPV-associated disease; in contrast, oral cavity squamous cell carcinoma (OCSCC) is associated with tobacco and alcohol use...
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| Veröffentlicht in: | American journal of otolaryngology 2019-01, Vol.40 (1), p.40-45 |
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| creator | Janz, Tyler A. Momin, Suhael R. Sterba, Katherine R. Kato, Masanari G. Armeson, Kent E. Day, Terry A. |
| description | The role of human papilloma virus (HPV) in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) is well documented, as is the excellent prognosis of patients with HPV-associated disease; in contrast, oral cavity squamous cell carcinoma (OCSCC) is associated with tobacco and alcohol use and has a worse prognosis. While causative factors, staging, and treatment guidelines differ between these cancer subsets, few studies have compared psychosocial factors in these groups.
To explore differences in psychosocial factors between HPV+ OPSCC patients versus OCSCC smokers.
A prospective cohort study at a single multidisciplinary, tertiary care HNC center was completed with recruitment from 2010 to 2013 using self-administered questionnaires before treatment and at 12 months. Patients were included with a diagnosis of HPV+ OPSCC or OCSCC with a smoking history. 38 (21 HPV+ OPSCC/17 OCSCC) met criteria. The main outcomes included self-efficacy, symptom severity, cancer worry, and depression.
A total of 38 (21 HPV+ OPSCC/17 OCSCC) patients (mean age: 57 [32–76], 73.7% male, 78.9% Caucasian, 71% stage IV) met inclusion criteria. OPSCC patients tended to be of male sex, Caucasian race, and single. Furthermore, OPSCC patients were more likely than OCSCC patients to have private insurance, be employed, and use alcohol and tobacco less frequently. Regarding psychosocial factors, HPV+ OPSCC patients reported lower symptom severity (2.7 versus 3.3), depression (12.0 versus 14.0) and cancer worry (2.8 versus 3.2) at baseline compared to OCSCC patients. Depression decreased significantly over time in OPSCC patients (12.0 to 9.9; effect size: −3.2 (95% CI: −5.9 to −0.4)). Although not statistically significant, cancer worry decreased in both groups (2.8 to 2.4 and 3.2 to 2.7, respectively, effect sizes: −0.3 (95% CI: −0.7–0.08) and −0.6 (95% CI: −1.2–0.05), respectively). No statistically significant differences in patterns of change over time were noted between groups.
This pilot study highlighted a pattern of reduced quality of life parameters in OCSCC patients at baseline with similar improvements over time compared to the OPSCC cohort. Although different in cancer etiology and treatment plans, HPV+ OPSCC and tobacco-related OCSCC patients both require multidisciplinary cancer care plans that address psychosocial concerns.
Level of evidence: 2B |
| doi_str_mv | 10.1016/j.amjoto.2018.08.010 |
| format | Article |
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To explore differences in psychosocial factors between HPV+ OPSCC patients versus OCSCC smokers.
A prospective cohort study at a single multidisciplinary, tertiary care HNC center was completed with recruitment from 2010 to 2013 using self-administered questionnaires before treatment and at 12 months. Patients were included with a diagnosis of HPV+ OPSCC or OCSCC with a smoking history. 38 (21 HPV+ OPSCC/17 OCSCC) met criteria. The main outcomes included self-efficacy, symptom severity, cancer worry, and depression.
A total of 38 (21 HPV+ OPSCC/17 OCSCC) patients (mean age: 57 [32–76], 73.7% male, 78.9% Caucasian, 71% stage IV) met inclusion criteria. OPSCC patients tended to be of male sex, Caucasian race, and single. Furthermore, OPSCC patients were more likely than OCSCC patients to have private insurance, be employed, and use alcohol and tobacco less frequently. Regarding psychosocial factors, HPV+ OPSCC patients reported lower symptom severity (2.7 versus 3.3), depression (12.0 versus 14.0) and cancer worry (2.8 versus 3.2) at baseline compared to OCSCC patients. Depression decreased significantly over time in OPSCC patients (12.0 to 9.9; effect size: −3.2 (95% CI: −5.9 to −0.4)). Although not statistically significant, cancer worry decreased in both groups (2.8 to 2.4 and 3.2 to 2.7, respectively, effect sizes: −0.3 (95% CI: −0.7–0.08) and −0.6 (95% CI: −1.2–0.05), respectively). No statistically significant differences in patterns of change over time were noted between groups.
This pilot study highlighted a pattern of reduced quality of life parameters in OCSCC patients at baseline with similar improvements over time compared to the OPSCC cohort. Although different in cancer etiology and treatment plans, HPV+ OPSCC and tobacco-related OCSCC patients both require multidisciplinary cancer care plans that address psychosocial concerns.
Level of evidence: 2B</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2018.08.010</identifier><identifier>PMID: 30322742</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Alcohol use ; Alcoholic beverages ; Cancer ; Cancer therapies ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - psychology ; Cohort Studies ; Comorbidity ; Data collection ; Depression ; Education ; Emotions ; Etiology ; Female ; Head & neck cancer ; Head and neck cancer ; Health insurance ; Human papilloma virus ; Human papillomavirus ; Humans ; Male ; Marital status ; Mental depression ; Middle Aged ; Mouth Neoplasms - etiology ; Mouth Neoplasms - psychology ; Oral cavity ; Oropharyngeal cancer ; Oropharyngeal Neoplasms - etiology ; Oropharyngeal Neoplasms - psychology ; Papillomaviridae ; Pathogenesis ; Patients ; Prognosis ; Psychosocial factors ; Quality of Life ; Self Efficacy ; Severity of Illness Index ; Smoking ; Smoking - adverse effects ; Socioeconomic Factors ; Squamous cell carcinoma ; Statistical analysis ; Statistical significance ; Throat cancer ; Time Factors ; Tobacco ; Viruses</subject><ispartof>American journal of otolaryngology, 2019-01, Vol.40 (1), p.40-45</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Jan 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-18a78e00f49842679bc9b7637b03aab9f40bcb2fcca215c9a41a4eb41824d6063</citedby><cites>FETCH-LOGICAL-c305t-18a78e00f49842679bc9b7637b03aab9f40bcb2fcca215c9a41a4eb41824d6063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019607091830810X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30322742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janz, Tyler A.</creatorcontrib><creatorcontrib>Momin, Suhael R.</creatorcontrib><creatorcontrib>Sterba, Katherine R.</creatorcontrib><creatorcontrib>Kato, Masanari G.</creatorcontrib><creatorcontrib>Armeson, Kent E.</creatorcontrib><creatorcontrib>Day, Terry A.</creatorcontrib><title>Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>The role of human papilloma virus (HPV) in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) is well documented, as is the excellent prognosis of patients with HPV-associated disease; in contrast, oral cavity squamous cell carcinoma (OCSCC) is associated with tobacco and alcohol use and has a worse prognosis. While causative factors, staging, and treatment guidelines differ between these cancer subsets, few studies have compared psychosocial factors in these groups.
To explore differences in psychosocial factors between HPV+ OPSCC patients versus OCSCC smokers.
A prospective cohort study at a single multidisciplinary, tertiary care HNC center was completed with recruitment from 2010 to 2013 using self-administered questionnaires before treatment and at 12 months. Patients were included with a diagnosis of HPV+ OPSCC or OCSCC with a smoking history. 38 (21 HPV+ OPSCC/17 OCSCC) met criteria. The main outcomes included self-efficacy, symptom severity, cancer worry, and depression.
A total of 38 (21 HPV+ OPSCC/17 OCSCC) patients (mean age: 57 [32–76], 73.7% male, 78.9% Caucasian, 71% stage IV) met inclusion criteria. OPSCC patients tended to be of male sex, Caucasian race, and single. Furthermore, OPSCC patients were more likely than OCSCC patients to have private insurance, be employed, and use alcohol and tobacco less frequently. Regarding psychosocial factors, HPV+ OPSCC patients reported lower symptom severity (2.7 versus 3.3), depression (12.0 versus 14.0) and cancer worry (2.8 versus 3.2) at baseline compared to OCSCC patients. Depression decreased significantly over time in OPSCC patients (12.0 to 9.9; effect size: −3.2 (95% CI: −5.9 to −0.4)). Although not statistically significant, cancer worry decreased in both groups (2.8 to 2.4 and 3.2 to 2.7, respectively, effect sizes: −0.3 (95% CI: −0.7–0.08) and −0.6 (95% CI: −1.2–0.05), respectively). No statistically significant differences in patterns of change over time were noted between groups.
This pilot study highlighted a pattern of reduced quality of life parameters in OCSCC patients at baseline with similar improvements over time compared to the OPSCC cohort. Although different in cancer etiology and treatment plans, HPV+ OPSCC and tobacco-related OCSCC patients both require multidisciplinary cancer care plans that address psychosocial concerns.
Level of evidence: 2B</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - psychology</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Data collection</subject><subject>Depression</subject><subject>Education</subject><subject>Emotions</subject><subject>Etiology</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Health insurance</subject><subject>Human papilloma virus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Male</subject><subject>Marital status</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - etiology</subject><subject>Mouth Neoplasms - psychology</subject><subject>Oral cavity</subject><subject>Oropharyngeal cancer</subject><subject>Oropharyngeal Neoplasms - etiology</subject><subject>Oropharyngeal Neoplasms - psychology</subject><subject>Papillomaviridae</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Psychosocial factors</subject><subject>Quality of Life</subject><subject>Self Efficacy</subject><subject>Severity of Illness Index</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Socioeconomic Factors</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Throat cancer</subject><subject>Time Factors</subject><subject>Tobacco</subject><subject>Viruses</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c-L1TAQB_Agivt29T8QKXgRlj4nP9q0F0Ee6goLelDxFqZpupvSdmqS9-CBf7xZ364HD8JADvnMJMyXsRccthx4_Wbc4jxSoq0A3mwhF4dHbMMrKcqGNz8esw3wti5BQ3vGzmMcAUAqWT1lZxKkEFqJDfu1o3nF4CMtBQ3FGo_2liJZj1MxoE0UYkEHF4rkZ1fgTMtNcfXl-2VBgdZbDMflxmVqcbEZ4dIXiTq0lsrgJkyuz_DP_cGn4wNbMXm3pPiMPRlwiu75_XnBvn14_3V3VV5__vhp9-66tBKqVPIGdeMABtU2StS67Wzb6VrqDiRi1w4KOtuJwVoUvLItKo7KdYo3QvU11PKCvT7NXQP93LuYzOyjddOEi6N9NIIL0JXSUmT66h860j4s-XdZKWg51KCzUidlA8UY3GDW4Oe8DcPB3KVjRnNKx9ylYyAXh9z28n74vptd_7fpIY4M3p6Ay9s4eBdMtHlT1vU-OJtMT_7_L_wGjyyjmg</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Janz, Tyler A.</creator><creator>Momin, Suhael R.</creator><creator>Sterba, Katherine R.</creator><creator>Kato, Masanari G.</creator><creator>Armeson, Kent E.</creator><creator>Day, Terry A.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients</title><author>Janz, Tyler A. ; Momin, Suhael R. ; Sterba, Katherine R. ; Kato, Masanari G. ; Armeson, Kent E. ; Day, Terry A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-18a78e00f49842679bc9b7637b03aab9f40bcb2fcca215c9a41a4eb41824d6063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - psychology</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Data collection</topic><topic>Depression</topic><topic>Education</topic><topic>Emotions</topic><topic>Etiology</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Health insurance</topic><topic>Human papilloma virus</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Male</topic><topic>Marital status</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - etiology</topic><topic>Mouth Neoplasms - psychology</topic><topic>Oral cavity</topic><topic>Oropharyngeal cancer</topic><topic>Oropharyngeal Neoplasms - etiology</topic><topic>Oropharyngeal Neoplasms - psychology</topic><topic>Papillomaviridae</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Psychosocial factors</topic><topic>Quality of Life</topic><topic>Self Efficacy</topic><topic>Severity of Illness Index</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Socioeconomic Factors</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><topic>Throat cancer</topic><topic>Time Factors</topic><topic>Tobacco</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janz, Tyler A.</creatorcontrib><creatorcontrib>Momin, Suhael R.</creatorcontrib><creatorcontrib>Sterba, Katherine R.</creatorcontrib><creatorcontrib>Kato, Masanari G.</creatorcontrib><creatorcontrib>Armeson, Kent E.</creatorcontrib><creatorcontrib>Day, Terry A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janz, Tyler A.</au><au>Momin, Suhael R.</au><au>Sterba, Katherine R.</au><au>Kato, Masanari G.</au><au>Armeson, Kent E.</au><au>Day, Terry A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2019-01</date><risdate>2019</risdate><volume>40</volume><issue>1</issue><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract>The role of human papilloma virus (HPV) in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) is well documented, as is the excellent prognosis of patients with HPV-associated disease; in contrast, oral cavity squamous cell carcinoma (OCSCC) is associated with tobacco and alcohol use and has a worse prognosis. While causative factors, staging, and treatment guidelines differ between these cancer subsets, few studies have compared psychosocial factors in these groups.
To explore differences in psychosocial factors between HPV+ OPSCC patients versus OCSCC smokers.
A prospective cohort study at a single multidisciplinary, tertiary care HNC center was completed with recruitment from 2010 to 2013 using self-administered questionnaires before treatment and at 12 months. Patients were included with a diagnosis of HPV+ OPSCC or OCSCC with a smoking history. 38 (21 HPV+ OPSCC/17 OCSCC) met criteria. The main outcomes included self-efficacy, symptom severity, cancer worry, and depression.
A total of 38 (21 HPV+ OPSCC/17 OCSCC) patients (mean age: 57 [32–76], 73.7% male, 78.9% Caucasian, 71% stage IV) met inclusion criteria. OPSCC patients tended to be of male sex, Caucasian race, and single. Furthermore, OPSCC patients were more likely than OCSCC patients to have private insurance, be employed, and use alcohol and tobacco less frequently. Regarding psychosocial factors, HPV+ OPSCC patients reported lower symptom severity (2.7 versus 3.3), depression (12.0 versus 14.0) and cancer worry (2.8 versus 3.2) at baseline compared to OCSCC patients. Depression decreased significantly over time in OPSCC patients (12.0 to 9.9; effect size: −3.2 (95% CI: −5.9 to −0.4)). Although not statistically significant, cancer worry decreased in both groups (2.8 to 2.4 and 3.2 to 2.7, respectively, effect sizes: −0.3 (95% CI: −0.7–0.08) and −0.6 (95% CI: −1.2–0.05), respectively). No statistically significant differences in patterns of change over time were noted between groups.
This pilot study highlighted a pattern of reduced quality of life parameters in OCSCC patients at baseline with similar improvements over time compared to the OPSCC cohort. Although different in cancer etiology and treatment plans, HPV+ OPSCC and tobacco-related OCSCC patients both require multidisciplinary cancer care plans that address psychosocial concerns.
Level of evidence: 2B</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30322742</pmid><doi>10.1016/j.amjoto.2018.08.010</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | American journal of otolaryngology, 2019-01, Vol.40 (1), p.40-45 |
| issn | 0196-0709 1532-818X |
| language | eng |
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| subjects | Adult Aged Alcohol use Alcoholic beverages Cancer Cancer therapies Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - psychology Cohort Studies Comorbidity Data collection Depression Education Emotions Etiology Female Head & neck cancer Head and neck cancer Health insurance Human papilloma virus Human papillomavirus Humans Male Marital status Mental depression Middle Aged Mouth Neoplasms - etiology Mouth Neoplasms - psychology Oral cavity Oropharyngeal cancer Oropharyngeal Neoplasms - etiology Oropharyngeal Neoplasms - psychology Papillomaviridae Pathogenesis Patients Prognosis Psychosocial factors Quality of Life Self Efficacy Severity of Illness Index Smoking Smoking - adverse effects Socioeconomic Factors Squamous cell carcinoma Statistical analysis Statistical significance Throat cancer Time Factors Tobacco Viruses |
| title | Comparison of psychosocial factors over time among HPV+ oropharyngeal cancer and tobacco-related oral cavity cancer patients |
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