The immunomodulatory effect of antimicrobial peptide HPA3P restricts Brucella abortus 544 infection in BALB/c mice

•HPA3P did not cause any cytotoxicity or bactericidal effect to B. abortus.•HPA3P inhibited bacterial internalization and reduced intracellular growth within macrophages.•Mice treated with HPA3P demonstrated a significant log reduction and spleen weight reduction compared to the nanocarrier control....

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Veröffentlicht in:	Veterinary microbiology 2018-11, Vol.225, p.17-24
Hauptverfasser:	Arayan, Lauren Togonon, Kim, Hyeun Bum, Bernardo Reyes, Alisha Wehdnesday, Xuan Huy, Ngoc Tran, Hong, Il Hwa, Lee, Kangseok, Yeom, Ji-Hyun, Park, Yoonkyung, Kim, Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Antimicrobial peptide Antimicrobial peptides Bacteria Bacteriology Brucella abortus Brucella abortus - drug effects Brucella abortus - growth & development Brucella abortus - immunology Brucellosis Brucellosis - immunology Brucellosis - microbiology Cytokines Cytokines - immunology Cytotoxicity Disease Models, Animal Drug resistance Granuloma HPA3P Immunologic Factors - administration & dosage Immunologic Factors - pharmacokinetics Immunomodulation Immunomodulators Infections Interferon Interferon-gamma - immunology Internalization Intracellular Liver Liver - microbiology Liver - pathology Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - microbiology Mice Mice, Inbred BALB C Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Multidrug resistance Peptides Peptides - administration & dosage Peptides - chemical synthesis Peptides - immunology Peptides - pharmacology Spleen Spleen - microbiology Spleen - pathology Tumor necrosis factor Tumor Necrosis Factor-alpha - immunology Weight reduction Zoonoses γ-Interferon
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