Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

The morphogenetic remodelling of embryo architecture after implantation culminates in pro-amniotic cavity formation. Despite its key importance, how this transformation occurs remains unknown. Here, we apply high-resolution imaging of embryos developing in vivo and in vitro, spatial RNA sequencing a...

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Veröffentlicht in:	Nature cell biology 2018-11, Vol.20 (11), p.1278-1289
Hauptverfasser:	Christodoulou, Neophytos, Kyprianou, Christos, Weberling, Antonia, Wang, Ran, Cui, Guizhong, Peng, Guangdun, Jing, Naihe, Zernicka-Goetz, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	14/63 38/1 45/91 631/136 631/136/2086 631/80/85 64/60 96/100 Animals Biomedical and Life Sciences Cancer Research Cavitation Cell Biology Cell culture Cells, Cultured Developmental Biology Embryo Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryogenesis Embryonic development Embryonic growth stage Embryos Exocytosis Female Gene Expression Profiling - methods Gene Expression Regulation, Developmental Gene sequencing Holes Image resolution Implantation Integrins Life Sciences Male Mice, Transgenic Microscopy Microscopy, Confocal Morphogenesis - genetics Nucleotide sequence Ovum implantation Ribonucleic acid RNA RNA sequencing Stem Cells Stem Cells - cytology Stem Cells - metabolism Structure Surgical implants Three dimensional models Trophoblasts - cytology Trophoblasts - metabolism
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