Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2

High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic acid (EPA) plus hydroxytyrosol (HT) supplementation prevents the inflammato...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2019-01, Vol.63, p.35-43
Hauptverfasser:	Echeverría, F., Valenzuela, R., Espinosa, A., Bustamante, A., Álvarez, D., Gonzalez-Mañan, D., Ortiz, M., Soto-Alarcon, S.A., Videla, L.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diet, High-Fat - adverse effects Dietary Supplements Docosahexaenoic Acids - metabolism Eicosapentaenoic Acid - analogs & derivatives Eicosapentaenoic Acid - metabolism Eicosapentaenoic Acid - pharmacology EPA Fatty Acids - metabolism Hepatic proinflammatory status Hepatitis - diet therapy Hepatitis - etiology Hepatitis - metabolism High-fat diet Hydroxytyrosol Liver - drug effects Liver - metabolism Liver steatosis Male Mice, Inbred C57BL NF-kappa B - metabolism Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Resolvins
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