Rotavirus Induces a Biphasic Enterotoxic and Cytotoxic Response in Human-Derived Intestinal Enterocytes, Which Is Inhibited by Human Immunoglobulins

The mechanisms of diarrhea due to rotavirus infection in humans are not fully understood; no specific therapy is available, but orally administered human serum immunoglobulins are effective in blocking stool output. We aimed to investigate the effect of rotavirus on ion transport and the role of NSP...

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Veröffentlicht in:	The Journal of infectious diseases 2009-09, Vol.200 (5), p.813-819
Hauptverfasser:	De Marco, Giulio, Bracale, Ileana, Buccigrossi, Vittoria, Bruzzese, Eugenia, Canani, Roberto Berni, Polito, Gaetano, Ruggeri, Franco Maria, Guarino, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Viral - immunology Biological and medical sciences Caco 2 cells Cell Death Cell Survival Chlorides - metabolism Diarrhea Enterocytes Enterocytes - physiology Enterocytes - virology Fundamental and applied biological sciences. Psychology Glycoproteins - toxicity Human rotavirus Humans Immunoglobulins Immunoglobulins - immunology Infections Infectious diseases Ion Transport Ions Medical sciences Microbiology Miscellaneous Neutralization Tests Permeability Rotavirus Rotavirus - pathogenicity Rotavirus infections Secretion Toxins, Biological - toxicity Viral Nonstructural Proteins - toxicity Virology Viruses
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