Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics

The biodegradation kinetics of BTE-oX and MTBE, mixed all together, in the presence of 905 mg/L VSS of BTEX-acclimated biomass was evaluated. Effects of soil and Tergitol NP-10 in aqueous samples on substrate biodegradation rates were also evaluated. Biodegradation kinetics was evaluated for 36 hour...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Water science and technology 2005-01, Vol.52 (8), p.107-115
Hauptverfasser: ACUNA-ASKAR, K, GRACIA-LOZANO, M. V, VILLARREAL-CHIU, I. F, MARMOLEJO, J. G, GARZA-GONZALEZ, M. T, CHAVEZ-GOMEZ, B
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 115
container_issue 8
container_start_page 107
container_title Water science and technology
container_volume 52
creator ACUNA-ASKAR, K
GRACIA-LOZANO, M. V
VILLARREAL-CHIU, I. F
MARMOLEJO, J. G
GARZA-GONZALEZ, M. T
CHAVEZ-GOMEZ, B
description The biodegradation kinetics of BTE-oX and MTBE, mixed all together, in the presence of 905 mg/L VSS of BTEX-acclimated biomass was evaluated. Effects of soil and Tergitol NP-10 in aqueous samples on substrate biodegradation rates were also evaluated. Biodegradation kinetics was evaluated for 36 hours, every 6 hours. MTBE biodegradation followed a first-order one-phase kinetic model in all samples, whereas benzene, toluene and ethylbenzene biodegradation followed a first-order two-phase kinetic model in all samples. O-xylene biodegradation followed a first-order two-phase kinetic model in the presence of biomass only. Interestingly, o-xylene biodegradation was able to switch to a first-order one-phase kinetic model when either soil or soil and Tergitol NP-10 were added. The presence of soil in aqueous samples retarded benzene, toluene and ethylbenzene removal rates. O-xylene and MTBE removal rates were enhanced by soil. The addition of Tergitol NP-10 to aqueous samples containing soil had a positive effect on substrate removal rate in all samples. Substrate percent removals ranged 77-99.8% for benzene, toluene and ethylbenzene. O-xylene and MTBE percent removals ranged 50.1-65.3% and 9.9-43.0%, respectively.
doi_str_mv 10.2166/wst.2005.0237
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21203892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1943576060</sourcerecordid><originalsourceid>FETCH-LOGICAL-a465t-a1b09e8fbf19b3cadfc1492c332f2e6ee520a2b5c4bfd8634cf678cee05a18a43</originalsourceid><addsrcrecordid>eNqF0c9rFDEUwPHgD-y2evQqAdHbrElefkyOWrZVKHiwQm_hTSaRqbNJTWYQ_3uzdqHgpRB4lw8PXr6EvOZsK7jWH37XZSsYU1smwDwhG26t7qwB8ZSc8l4CWKXUzTOyYcJAx4WAE3Ja6y1jzIBkL8gJ18CFVWZDvu1iDH6hOdKap5liGinSlNPUnqd1LRH9gqmJRD9d77p888_slyHQYcpj-FFwxKVx-nNKYZl8fUmeR5xreHWcZ-T7xe76_HN39fXyy_nHqw6lVkuHfGA29HGI3A7gcYyeSys8gIgi6BCUYCgG5eUQx16D9FGb3ofAFPIeJZyR9_d770r-tYa6uP1UfZhnTCGv1QkuGPRWPAq5kcBl-5xHoTRaW9U3-PY_eJvXktq1jlsJymimWVPdvfIl11pCdHdl2mP54zhzh5SupXSHlO6Qsvk3x63rsA_jgz7mauDdEWD1OMeCyU_1wZmWXoCAvwDxo40</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1943576060</pqid></control><display><type>article</type><title>Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>ACUNA-ASKAR, K ; GRACIA-LOZANO, M. V ; VILLARREAL-CHIU, I. F ; MARMOLEJO, J. G ; GARZA-GONZALEZ, M. T ; CHAVEZ-GOMEZ, B</creator><creatorcontrib>ACUNA-ASKAR, K ; GRACIA-LOZANO, M. V ; VILLARREAL-CHIU, I. F ; MARMOLEJO, J. G ; GARZA-GONZALEZ, M. T ; CHAVEZ-GOMEZ, B</creatorcontrib><description>The biodegradation kinetics of BTE-oX and MTBE, mixed all together, in the presence of 905 mg/L VSS of BTEX-acclimated biomass was evaluated. Effects of soil and Tergitol NP-10 in aqueous samples on substrate biodegradation rates were also evaluated. Biodegradation kinetics was evaluated for 36 hours, every 6 hours. MTBE biodegradation followed a first-order one-phase kinetic model in all samples, whereas benzene, toluene and ethylbenzene biodegradation followed a first-order two-phase kinetic model in all samples. O-xylene biodegradation followed a first-order two-phase kinetic model in the presence of biomass only. Interestingly, o-xylene biodegradation was able to switch to a first-order one-phase kinetic model when either soil or soil and Tergitol NP-10 were added. The presence of soil in aqueous samples retarded benzene, toluene and ethylbenzene removal rates. O-xylene and MTBE removal rates were enhanced by soil. The addition of Tergitol NP-10 to aqueous samples containing soil had a positive effect on substrate removal rate in all samples. Substrate percent removals ranged 77-99.8% for benzene, toluene and ethylbenzene. O-xylene and MTBE percent removals ranged 50.1-65.3% and 9.9-43.0%, respectively.</description><identifier>ISSN: 0273-1223</identifier><identifier>ISBN: 184339555X</identifier><identifier>ISBN: 9781843395553</identifier><identifier>EISSN: 1996-9732</identifier><identifier>DOI: 10.2166/wst.2005.0237</identifier><identifier>PMID: 16312957</identifier><identifier>CODEN: WSTED4</identifier><language>eng</language><publisher>Oxford: Pergamon</publisher><subject>Air. Soil. Water. Waste. Feeding ; Applied sciences ; Benzene ; Benzene Derivatives - metabolism ; Biodegradation ; Biodegradation, Environmental ; Biological and medical sciences ; Biomass ; Environment. Living conditions ; Ethylbenzene ; Exact sciences and technology ; Hydrocarbons ; Kinetics ; Medical sciences ; Methyl Ethers - metabolism ; Models, Theoretical ; MTBE ; Pollution ; Poloxalene - metabolism ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Removal ; Soil ; Soil - analysis ; Soil Microbiology ; Soil Pollutants - metabolism ; Soils ; Surface-Active Agents - metabolism ; Toluene ; Water treatment and pollution ; Xylene</subject><ispartof>Water science and technology, 2005-01, Vol.52 (8), p.107-115</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright IWA Publishing Oct 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a465t-a1b09e8fbf19b3cadfc1492c332f2e6ee520a2b5c4bfd8634cf678cee05a18a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=17395232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16312957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ACUNA-ASKAR, K</creatorcontrib><creatorcontrib>GRACIA-LOZANO, M. V</creatorcontrib><creatorcontrib>VILLARREAL-CHIU, I. F</creatorcontrib><creatorcontrib>MARMOLEJO, J. G</creatorcontrib><creatorcontrib>GARZA-GONZALEZ, M. T</creatorcontrib><creatorcontrib>CHAVEZ-GOMEZ, B</creatorcontrib><title>Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics</title><title>Water science and technology</title><addtitle>Water Sci Technol</addtitle><description>The biodegradation kinetics of BTE-oX and MTBE, mixed all together, in the presence of 905 mg/L VSS of BTEX-acclimated biomass was evaluated. Effects of soil and Tergitol NP-10 in aqueous samples on substrate biodegradation rates were also evaluated. Biodegradation kinetics was evaluated for 36 hours, every 6 hours. MTBE biodegradation followed a first-order one-phase kinetic model in all samples, whereas benzene, toluene and ethylbenzene biodegradation followed a first-order two-phase kinetic model in all samples. O-xylene biodegradation followed a first-order two-phase kinetic model in the presence of biomass only. Interestingly, o-xylene biodegradation was able to switch to a first-order one-phase kinetic model when either soil or soil and Tergitol NP-10 were added. The presence of soil in aqueous samples retarded benzene, toluene and ethylbenzene removal rates. O-xylene and MTBE removal rates were enhanced by soil. The addition of Tergitol NP-10 to aqueous samples containing soil had a positive effect on substrate removal rate in all samples. Substrate percent removals ranged 77-99.8% for benzene, toluene and ethylbenzene. O-xylene and MTBE percent removals ranged 50.1-65.3% and 9.9-43.0%, respectively.</description><subject>Air. Soil. Water. Waste. Feeding</subject><subject>Applied sciences</subject><subject>Benzene</subject><subject>Benzene Derivatives - metabolism</subject><subject>Biodegradation</subject><subject>Biodegradation, Environmental</subject><subject>Biological and medical sciences</subject><subject>Biomass</subject><subject>Environment. Living conditions</subject><subject>Ethylbenzene</subject><subject>Exact sciences and technology</subject><subject>Hydrocarbons</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Methyl Ethers - metabolism</subject><subject>Models, Theoretical</subject><subject>MTBE</subject><subject>Pollution</subject><subject>Poloxalene - metabolism</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Removal</subject><subject>Soil</subject><subject>Soil - analysis</subject><subject>Soil Microbiology</subject><subject>Soil Pollutants - metabolism</subject><subject>Soils</subject><subject>Surface-Active Agents - metabolism</subject><subject>Toluene</subject><subject>Water treatment and pollution</subject><subject>Xylene</subject><issn>0273-1223</issn><issn>1996-9732</issn><isbn>184339555X</isbn><isbn>9781843395553</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0c9rFDEUwPHgD-y2evQqAdHbrElefkyOWrZVKHiwQm_hTSaRqbNJTWYQ_3uzdqHgpRB4lw8PXr6EvOZsK7jWH37XZSsYU1smwDwhG26t7qwB8ZSc8l4CWKXUzTOyYcJAx4WAE3Ja6y1jzIBkL8gJ18CFVWZDvu1iDH6hOdKap5liGinSlNPUnqd1LRH9gqmJRD9d77p888_slyHQYcpj-FFwxKVx-nNKYZl8fUmeR5xreHWcZ-T7xe76_HN39fXyy_nHqw6lVkuHfGA29HGI3A7gcYyeSys8gIgi6BCUYCgG5eUQx16D9FGb3ofAFPIeJZyR9_d770r-tYa6uP1UfZhnTCGv1QkuGPRWPAq5kcBl-5xHoTRaW9U3-PY_eJvXktq1jlsJymimWVPdvfIl11pCdHdl2mP54zhzh5SupXSHlO6Qsvk3x63rsA_jgz7mauDdEWD1OMeCyU_1wZmWXoCAvwDxo40</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>ACUNA-ASKAR, K</creator><creator>GRACIA-LOZANO, M. V</creator><creator>VILLARREAL-CHIU, I. F</creator><creator>MARMOLEJO, J. G</creator><creator>GARZA-GONZALEZ, M. T</creator><creator>CHAVEZ-GOMEZ, B</creator><general>Pergamon</general><general>IWA Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H96</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7ST</scope><scope>SOI</scope><scope>7QO</scope><scope>7T7</scope><scope>7TV</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20050101</creationdate><title>Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics</title><author>ACUNA-ASKAR, K ; GRACIA-LOZANO, M. V ; VILLARREAL-CHIU, I. F ; MARMOLEJO, J. G ; GARZA-GONZALEZ, M. T ; CHAVEZ-GOMEZ, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a465t-a1b09e8fbf19b3cadfc1492c332f2e6ee520a2b5c4bfd8634cf678cee05a18a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Air. Soil. Water. Waste. Feeding</topic><topic>Applied sciences</topic><topic>Benzene</topic><topic>Benzene Derivatives - metabolism</topic><topic>Biodegradation</topic><topic>Biodegradation, Environmental</topic><topic>Biological and medical sciences</topic><topic>Biomass</topic><topic>Environment. Living conditions</topic><topic>Ethylbenzene</topic><topic>Exact sciences and technology</topic><topic>Hydrocarbons</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Methyl Ethers - metabolism</topic><topic>Models, Theoretical</topic><topic>MTBE</topic><topic>Pollution</topic><topic>Poloxalene - metabolism</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Removal</topic><topic>Soil</topic><topic>Soil - analysis</topic><topic>Soil Microbiology</topic><topic>Soil Pollutants - metabolism</topic><topic>Soils</topic><topic>Surface-Active Agents - metabolism</topic><topic>Toluene</topic><topic>Water treatment and pollution</topic><topic>Xylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ACUNA-ASKAR, K</creatorcontrib><creatorcontrib>GRACIA-LOZANO, M. V</creatorcontrib><creatorcontrib>VILLARREAL-CHIU, I. F</creatorcontrib><creatorcontrib>MARMOLEJO, J. G</creatorcontrib><creatorcontrib>GARZA-GONZALEZ, M. T</creatorcontrib><creatorcontrib>CHAVEZ-GOMEZ, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Water Resources Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy &amp; Non-Living Resources</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) 3: Aquatic Pollution &amp; Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Aquatic Science &amp; Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Engineering Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Water science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ACUNA-ASKAR, K</au><au>GRACIA-LOZANO, M. V</au><au>VILLARREAL-CHIU, I. F</au><au>MARMOLEJO, J. G</au><au>GARZA-GONZALEZ, M. T</au><au>CHAVEZ-GOMEZ, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics</atitle><jtitle>Water science and technology</jtitle><addtitle>Water Sci Technol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>52</volume><issue>8</issue><spage>107</spage><epage>115</epage><pages>107-115</pages><issn>0273-1223</issn><eissn>1996-9732</eissn><isbn>184339555X</isbn><isbn>9781843395553</isbn><coden>WSTED4</coden><abstract>The biodegradation kinetics of BTE-oX and MTBE, mixed all together, in the presence of 905 mg/L VSS of BTEX-acclimated biomass was evaluated. Effects of soil and Tergitol NP-10 in aqueous samples on substrate biodegradation rates were also evaluated. Biodegradation kinetics was evaluated for 36 hours, every 6 hours. MTBE biodegradation followed a first-order one-phase kinetic model in all samples, whereas benzene, toluene and ethylbenzene biodegradation followed a first-order two-phase kinetic model in all samples. O-xylene biodegradation followed a first-order two-phase kinetic model in the presence of biomass only. Interestingly, o-xylene biodegradation was able to switch to a first-order one-phase kinetic model when either soil or soil and Tergitol NP-10 were added. The presence of soil in aqueous samples retarded benzene, toluene and ethylbenzene removal rates. O-xylene and MTBE removal rates were enhanced by soil. The addition of Tergitol NP-10 to aqueous samples containing soil had a positive effect on substrate removal rate in all samples. Substrate percent removals ranged 77-99.8% for benzene, toluene and ethylbenzene. O-xylene and MTBE percent removals ranged 50.1-65.3% and 9.9-43.0%, respectively.</abstract><cop>Oxford</cop><pub>Pergamon</pub><pmid>16312957</pmid><doi>10.2166/wst.2005.0237</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0273-1223
ispartof Water science and technology, 2005-01, Vol.52 (8), p.107-115
issn 0273-1223
1996-9732
language eng
recordid cdi_proquest_miscellaneous_21203892
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Air. Soil. Water. Waste. Feeding
Applied sciences
Benzene
Benzene Derivatives - metabolism
Biodegradation
Biodegradation, Environmental
Biological and medical sciences
Biomass
Environment. Living conditions
Ethylbenzene
Exact sciences and technology
Hydrocarbons
Kinetics
Medical sciences
Methyl Ethers - metabolism
Models, Theoretical
MTBE
Pollution
Poloxalene - metabolism
Public health. Hygiene
Public health. Hygiene-occupational medicine
Removal
Soil
Soil - analysis
Soil Microbiology
Soil Pollutants - metabolism
Soils
Surface-Active Agents - metabolism
Toluene
Water treatment and pollution
Xylene
title Effect of soil and a nonionic surfactant on BTE-oX and mtbe biodegradation kinetics
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T20%3A22%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20soil%20and%20a%20nonionic%20surfactant%20on%20BTE-oX%20and%20mtbe%20biodegradation%20kinetics&rft.jtitle=Water%20science%20and%20technology&rft.au=ACUNA-ASKAR,%20K&rft.date=2005-01-01&rft.volume=52&rft.issue=8&rft.spage=107&rft.epage=115&rft.pages=107-115&rft.issn=0273-1223&rft.eissn=1996-9732&rft.isbn=184339555X&rft.isbn_list=9781843395553&rft.coden=WSTED4&rft_id=info:doi/10.2166/wst.2005.0237&rft_dat=%3Cproquest_cross%3E1943576060%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1943576060&rft_id=info:pmid/16312957&rfr_iscdi=true