CCN2 promotes drug resistance in osteosarcoma by enhancing ABCG2 expression

In recent years, osteosarcoma survival rates have failed to improve significantly with conventional treatment modalities because of the development of chemotherapeutic resistance. The human breast cancer resistance protein/ATP binding cassette subfamily G member 2 (BCRP/ABCG2), a member of the ATP‐b...

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Veröffentlicht in:	Journal of cellular physiology 2019-06, Vol.234 (6), p.9297-9307
Hauptverfasser:	Tsai, Hsiao‐Chi, Chang, An‐Chen, Tsai, Chun‐Hao, Huang, Yuan‐Li, Gan, Lijun, Chen, Chi‐Kuan, Liu, Shih‐Chia, Huang, Te‐Yang, Fong, Yi‐Chin, Tang, Chih‐Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 Animals ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics Base Sequence Binding Biocompatibility Bone cancer Breast cancer Cancer CCN2 Cell Line, Tumor Cell Survival - genetics Chemoresistance chemotherapeutic resistance Connective tissue growth factor Connective Tissue Growth Factor - metabolism Doxorubicin Drug resistance Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Humans Integrin alpha6beta1 - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism Models, Biological Neoplasm Proteins - genetics Osteosarcoma Osteosarcoma - genetics Proteins Sarcoma Signal Transduction Survival Xenobiotics Xenografts Xenotransplantation
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