Evolution of Metastases in Space and Time under Immune Selection

We examined how the immune microenvironment molds tumor evolution at different metastatic organs in a longitudinal dataset of colorectal cancer. Through multiplexed analyses, we showed that clonal evolution patterns during metastatic progression depend on the immune contexture at the metastatic site...

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Veröffentlicht in:	Cell 2018-10, Vol.175 (3), p.751-765.e16
Hauptverfasser:	Angelova, Mihaela, Mlecnik, Bernhard, Vasaturo, Angela, Bindea, Gabriela, Fredriksen, Tessa, Lafontaine, Lucie, Buttard, Bénédicte, Morgand, Erwan, Bruni, Daniela, Jouret-Mourin, Anne, Hubert, Catherine, Kartheuser, Alex, Humblet, Yves, Ceccarelli, Michele, Syed, Najeeb, Marincola, Francesco M., Bedognetti, Davide, Van den Eynde, Marc, Galon, Jérôme
Format:	Artikel
Sprache:	eng
Schlagworte:	clonal heterogeneity immunoediting immunoscore immunotherapy metastasis microenvironment mutations recurrence T cells
Online-Zugang:	Volltext
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