Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms
The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c.1236C>T), rs2032582 (c.2677G>T/A), and rs1045642 (c.3435C>T). Although variation in ABCB1 allele frequencies among Mexican Mestizos (admixed) from different regions has been observed, Mexican Amerindians have been poor...
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| creator | Favela-Mendoza, Alma Faviola Rangel-Villalobos, Héctor Fricke-Galindo, Ingrid Ortega-Vázquez, Alberto Martínez-Cortés, Gabriela López-López, Marisol |
| description | The most widely studied polymorphisms of the
ABCB1
gene are rs1128503 (c.1236C>T), rs2032582 (c.2677G>T/A), and rs1045642 (c.3435C>T). Although variation in
ABCB1
allele frequencies among Mexican Mestizos (admixed) from different regions has been observed, Mexican Amerindians have been poorly studied. We aimed to describe the genetic variability of these three
ABCB1
polymorphisms in a total sample of 273 Mexican volunteers that included Mestizos from the state of Yucatán, and Amerindians from seven populations (Tarahumara, Mayo, Huichol, Purépecha, Nahua, Tojolabal, and Maya). Genotypes were determined by means of Taq Man probes (qPCR). Genotype distribution was in Hardy–Weinberg equilibrium for all three
ABCB1
polymorphisms in the eight Mexican populations analyzed. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype in the majority of the studied Mexican populations (range 30.8–65.4%), while heterozygous G/T was the most common genotype for c.2677G>T/A (range 25.9–51.2%), mainly followed by G/G (range 3.2–47.1%) and T/T (range 7.0–35.5%). 12 haplotypes were estimated from the three
ABCB1
polymorphisms analyzed, with TTT the most frequent haplotype (mean, 37.0%). Genetic differentiation was demonstrated among the studied Mexican populations (Fst
p
value |
| doi_str_mv | 10.1007/s11033-018-4419-x |
| format | Article |
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ABCB1
gene are rs1128503 (c.1236C>T), rs2032582 (c.2677G>T/A), and rs1045642 (c.3435C>T). Although variation in
ABCB1
allele frequencies among Mexican Mestizos (admixed) from different regions has been observed, Mexican Amerindians have been poorly studied. We aimed to describe the genetic variability of these three
ABCB1
polymorphisms in a total sample of 273 Mexican volunteers that included Mestizos from the state of Yucatán, and Amerindians from seven populations (Tarahumara, Mayo, Huichol, Purépecha, Nahua, Tojolabal, and Maya). Genotypes were determined by means of Taq Man probes (qPCR). Genotype distribution was in Hardy–Weinberg equilibrium for all three
ABCB1
polymorphisms in the eight Mexican populations analyzed. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype in the majority of the studied Mexican populations (range 30.8–65.4%), while heterozygous G/T was the most common genotype for c.2677G>T/A (range 25.9–51.2%), mainly followed by G/G (range 3.2–47.1%) and T/T (range 7.0–35.5%). 12 haplotypes were estimated from the three
ABCB1
polymorphisms analyzed, with TTT the most frequent haplotype (mean, 37.0%). Genetic differentiation was demonstrated among the studied Mexican populations (Fst
p
value < 0.0001), which could imply a diverse drug response or a risk for adverse drug reactions to ABCB1 substrates. Although differences among Amerindians are probably due to genetic drift effects, for Mestizos this could imply variation in admixture composition. In conclusion, interpopulation variability in the observed frequencies of
ABCB1
polymorphisms among Mexican Mestizos and Amerindians allow predicting diverse drug responses to ABCB1 substrates in these populations.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-018-4419-x</identifier><identifier>PMID: 30317428</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Biomedical and Life Sciences ; Gene frequency ; Genetic drift ; Genetic variability ; Genotype & phenotype ; Haplotypes ; Histology ; Life Sciences ; Morphology ; Original Article ; Population studies</subject><ispartof>Molecular biology reports, 2018-12, Vol.45 (6), p.2525-2533</ispartof><rights>Springer Nature B.V. 2018</rights><rights>Molecular Biology Reports is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-eae9e6d2a1bce61d1564d3e7ebbb975f884489629265299a96b13fa3b837005b3</citedby><cites>FETCH-LOGICAL-c372t-eae9e6d2a1bce61d1564d3e7ebbb975f884489629265299a96b13fa3b837005b3</cites><orcidid>0000-0002-3954-8052</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-018-4419-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-018-4419-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30317428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Favela-Mendoza, Alma Faviola</creatorcontrib><creatorcontrib>Rangel-Villalobos, Héctor</creatorcontrib><creatorcontrib>Fricke-Galindo, Ingrid</creatorcontrib><creatorcontrib>Ortega-Vázquez, Alberto</creatorcontrib><creatorcontrib>Martínez-Cortés, Gabriela</creatorcontrib><creatorcontrib>López-López, Marisol</creatorcontrib><title>Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>The most widely studied polymorphisms of the
ABCB1
gene are rs1128503 (c.1236C>T), rs2032582 (c.2677G>T/A), and rs1045642 (c.3435C>T). Although variation in
ABCB1
allele frequencies among Mexican Mestizos (admixed) from different regions has been observed, Mexican Amerindians have been poorly studied. We aimed to describe the genetic variability of these three
ABCB1
polymorphisms in a total sample of 273 Mexican volunteers that included Mestizos from the state of Yucatán, and Amerindians from seven populations (Tarahumara, Mayo, Huichol, Purépecha, Nahua, Tojolabal, and Maya). Genotypes were determined by means of Taq Man probes (qPCR). Genotype distribution was in Hardy–Weinberg equilibrium for all three
ABCB1
polymorphisms in the eight Mexican populations analyzed. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype in the majority of the studied Mexican populations (range 30.8–65.4%), while heterozygous G/T was the most common genotype for c.2677G>T/A (range 25.9–51.2%), mainly followed by G/G (range 3.2–47.1%) and T/T (range 7.0–35.5%). 12 haplotypes were estimated from the three
ABCB1
polymorphisms analyzed, with TTT the most frequent haplotype (mean, 37.0%). Genetic differentiation was demonstrated among the studied Mexican populations (Fst
p
value < 0.0001), which could imply a diverse drug response or a risk for adverse drug reactions to ABCB1 substrates. Although differences among Amerindians are probably due to genetic drift effects, for Mestizos this could imply variation in admixture composition. In conclusion, interpopulation variability in the observed frequencies of
ABCB1
polymorphisms among Mexican Mestizos and Amerindians allow predicting diverse drug responses to ABCB1 substrates in these populations.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Gene frequency</subject><subject>Genetic drift</subject><subject>Genetic variability</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Histology</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Population studies</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFv1DAQhS0EokvhB3BBlrj0EvDYThwftytoK7XiAmfLTma3rhI72Ana5dfXqy0gIfU00sw3b57mEfIe2CdgTH3OAEyIikFbSQm62r8gK6iVqKRW7UuyYoJBJdsazsibnB8YYxJU_ZqcCSZASd6uyO4KA86-o79s8tb5wc8HascYdvQO976zodQ8-9-R2tDT9YjJh96X9hSnZbCzjyFTZzP2NAY63ydEur7cXEIBhsMY03Tv85jfkldbO2R891TPyY-vX75vrqvbb1c3m_Vt1QnF5wotamx6bsF12EAPdSN7gQqdc1rV27aVstUN17ypudZWNw7E1grXCsVY7cQ5uTjpTin-XIpzM_rc4TDYgHHJhgNnnImmYQX9-B_6EJcUirtCgWZScn2k4ER1KeaccGum5EebDgaYOaZgTimYkoI5pmD2ZefDk_LiRuz_bvx5ewH4CchlFHaY_p1-XvURFLaShw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Favela-Mendoza, Alma Faviola</creator><creator>Rangel-Villalobos, Héctor</creator><creator>Fricke-Galindo, Ingrid</creator><creator>Ortega-Vázquez, Alberto</creator><creator>Martínez-Cortés, Gabriela</creator><creator>López-López, Marisol</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3954-8052</orcidid></search><sort><creationdate>20181201</creationdate><title>Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms</title><author>Favela-Mendoza, Alma Faviola ; 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ABCB1
gene are rs1128503 (c.1236C>T), rs2032582 (c.2677G>T/A), and rs1045642 (c.3435C>T). Although variation in
ABCB1
allele frequencies among Mexican Mestizos (admixed) from different regions has been observed, Mexican Amerindians have been poorly studied. We aimed to describe the genetic variability of these three
ABCB1
polymorphisms in a total sample of 273 Mexican volunteers that included Mestizos from the state of Yucatán, and Amerindians from seven populations (Tarahumara, Mayo, Huichol, Purépecha, Nahua, Tojolabal, and Maya). Genotypes were determined by means of Taq Man probes (qPCR). Genotype distribution was in Hardy–Weinberg equilibrium for all three
ABCB1
polymorphisms in the eight Mexican populations analyzed. For c.1236C>T and c.3435C>T, the heterozygous C/T was the most frequent genotype in the majority of the studied Mexican populations (range 30.8–65.4%), while heterozygous G/T was the most common genotype for c.2677G>T/A (range 25.9–51.2%), mainly followed by G/G (range 3.2–47.1%) and T/T (range 7.0–35.5%). 12 haplotypes were estimated from the three
ABCB1
polymorphisms analyzed, with TTT the most frequent haplotype (mean, 37.0%). Genetic differentiation was demonstrated among the studied Mexican populations (Fst
p
value < 0.0001), which could imply a diverse drug response or a risk for adverse drug reactions to ABCB1 substrates. Although differences among Amerindians are probably due to genetic drift effects, for Mestizos this could imply variation in admixture composition. In conclusion, interpopulation variability in the observed frequencies of
ABCB1
polymorphisms among Mexican Mestizos and Amerindians allow predicting diverse drug responses to ABCB1 substrates in these populations.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30317428</pmid><doi>10.1007/s11033-018-4419-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3954-8052</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Biomedical and Life Sciences Gene frequency Genetic drift Genetic variability Genotype & phenotype Haplotypes Histology Life Sciences Morphology Original Article Population studies |
| title | Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms |
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