Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer
Aggregation‐induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4‐vinylbenzyl‐terminated tetraphenylporphyrin (VBTPP) and maleimide...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2018-12, Vol.57 (50), p.16354-16358 |
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| creator | Jin, Jianqiu Zhu, Yucheng Zhang, Zhenghe Zhang, Weian |
| description | Aggregation‐induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4‐vinylbenzyl‐terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition–fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self‐assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy.
Nanoparticles formed by self‐assembly of amphiphilic block copolymers were investigated for their potential application in photodynamic therapy. The porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, thus providing a novel strategy to enhance the PDT efficacy. |
| doi_str_mv | 10.1002/anie.201808811 |
| format | Article |
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Nanoparticles formed by self‐assembly of amphiphilic block copolymers were investigated for their potential application in photodynamic therapy. The porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, thus providing a novel strategy to enhance the PDT efficacy.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201808811</identifier><identifier>PMID: 30318668</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>A549 Cells ; Addition polymerization ; Agglomeration ; Animals ; block copolymer ; Block copolymers ; Chain transfer ; Effectiveness ; Humans ; Mice ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Nanoparticles - ultrastructure ; Neoplasms - drug therapy ; Neoplasms - pathology ; Organosilicon Compounds - chemistry ; Organosilicon Compounds - therapeutic use ; Photochemicals ; Photochemotherapy ; Photodynamic therapy ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - therapeutic use ; Phototoxicity ; Polyhedral oligomeric silsesquioxane ; Polymerization ; porphyrin ; Porphyrins - chemistry ; Porphyrins - therapeutic use ; POSS ; self-assembly ; Singlet oxygen ; Singlet Oxygen - chemistry</subject><ispartof>Angewandte Chemie International Edition, 2018-12, Vol.57 (50), p.16354-16358</ispartof><rights>2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4761-551e05de9082f35070f81d9b4f1595a064ec26c3cdd5cd8fc6bce65725181b613</citedby><cites>FETCH-LOGICAL-c4761-551e05de9082f35070f81d9b4f1595a064ec26c3cdd5cd8fc6bce65725181b613</cites><orcidid>0000-0002-1717-597X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201808811$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201808811$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30318668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Jianqiu</creatorcontrib><creatorcontrib>Zhu, Yucheng</creatorcontrib><creatorcontrib>Zhang, Zhenghe</creatorcontrib><creatorcontrib>Zhang, Weian</creatorcontrib><title>Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Aggregation‐induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4‐vinylbenzyl‐terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition–fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self‐assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy.
Nanoparticles formed by self‐assembly of amphiphilic block copolymers were investigated for their potential application in photodynamic therapy. The porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, thus providing a novel strategy to enhance the PDT efficacy.</description><subject>A549 Cells</subject><subject>Addition polymerization</subject><subject>Agglomeration</subject><subject>Animals</subject><subject>block copolymer</subject><subject>Block copolymers</subject><subject>Chain transfer</subject><subject>Effectiveness</subject><subject>Humans</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Nanoparticles - ultrastructure</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>Organosilicon Compounds - chemistry</subject><subject>Organosilicon Compounds - therapeutic use</subject><subject>Photochemicals</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Phototoxicity</subject><subject>Polyhedral oligomeric silsesquioxane</subject><subject>Polymerization</subject><subject>porphyrin</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - therapeutic use</subject><subject>POSS</subject><subject>self-assembly</subject><subject>Singlet oxygen</subject><subject>Singlet Oxygen - chemistry</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EFLwzAchvEgipvTq0cpePHSLf-mSdPjGFMHww02j1KyNFk72qamLdJvb8vmBC-eksMvD-FF6B7wGDD2JqJI1djDwDHnABdoCNQDlwQBuezuPiFuwCkM0E1VHTrPOWbXaEAwAc4YH6KPeZGIQqbF3qkT5cy1TqWQrWO0s05MbeK2EHkqnW2irCjbDlnT7BNHOGtjy6S1aTFZrzYbZ5rVyhai7kszU5qszZW9RVdaZJW6O50j9P48385e3eXqZTGbLl3pBwxcSkFhGqsQc08TigOsOcThztdAQyow85X0mCQyjqmMuZZsJxWjgUeBw44BGaGnY7e05rNRVR3laSVVlolCmaaKPPBwPxIJOvr4hx5M030865XPGUBI_U6Nj0paU1VW6ai0aS5sGwGO-uGjfvjoPHz34OGUbXa5is_8Z-kOhEfwlWaq_ScXTd8W89_4N45njpY</recordid><startdate>20181210</startdate><enddate>20181210</enddate><creator>Jin, Jianqiu</creator><creator>Zhu, Yucheng</creator><creator>Zhang, Zhenghe</creator><creator>Zhang, Weian</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1717-597X</orcidid></search><sort><creationdate>20181210</creationdate><title>Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer</title><author>Jin, Jianqiu ; Zhu, Yucheng ; Zhang, Zhenghe ; Zhang, Weian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4761-551e05de9082f35070f81d9b4f1595a064ec26c3cdd5cd8fc6bce65725181b613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>A549 Cells</topic><topic>Addition polymerization</topic><topic>Agglomeration</topic><topic>Animals</topic><topic>block copolymer</topic><topic>Block copolymers</topic><topic>Chain transfer</topic><topic>Effectiveness</topic><topic>Humans</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Nanoparticles - ultrastructure</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>Organosilicon Compounds - chemistry</topic><topic>Organosilicon Compounds - therapeutic use</topic><topic>Photochemicals</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Phototoxicity</topic><topic>Polyhedral oligomeric silsesquioxane</topic><topic>Polymerization</topic><topic>porphyrin</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - therapeutic use</topic><topic>POSS</topic><topic>self-assembly</topic><topic>Singlet oxygen</topic><topic>Singlet Oxygen - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Jianqiu</creatorcontrib><creatorcontrib>Zhu, Yucheng</creatorcontrib><creatorcontrib>Zhang, Zhenghe</creatorcontrib><creatorcontrib>Zhang, Weian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Jianqiu</au><au>Zhu, Yucheng</au><au>Zhang, Zhenghe</au><au>Zhang, Weian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2018-12-10</date><risdate>2018</risdate><volume>57</volume><issue>50</issue><spage>16354</spage><epage>16358</epage><pages>16354-16358</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Aggregation‐induced quenching (AIQ) of photosensitizers greatly reduces the quantum yield of singlet oxygen generation and mitigates the efficacy of photodynamic therapy (PDT). We have prepared an alternating copolymer starting from 4‐vinylbenzyl‐terminated tetraphenylporphyrin (VBTPP) and maleimide isobutyl polyhedral oligomeric silsesquioxane (MIPOSS), via alternating reversible addition–fragmentation chain transfer (RAFT) polymerization. Porphyrin and POSS are installed on the amphiphilic block copolymers backbone in an alternating fashion and POSS completely inhibits the aggregation of porphyrin units via stacking. The amphiphilic block copolymer can self‐assemble into nanoparticles and its application in PDT treatment was tested. These porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, providing a novel strategy to enhance the PDT efficacy.
Nanoparticles formed by self‐assembly of amphiphilic block copolymers were investigated for their potential application in photodynamic therapy. The porphyrin‐containing polymeric nanoparticles display high photochemical yield and phototoxicity in vitro and in vivo, thus providing a novel strategy to enhance the PDT efficacy.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30318668</pmid><doi>10.1002/anie.201808811</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-1717-597X</orcidid></addata></record> |
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| subjects | A549 Cells Addition polymerization Agglomeration Animals block copolymer Block copolymers Chain transfer Effectiveness Humans Mice Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Nanoparticles - ultrastructure Neoplasms - drug therapy Neoplasms - pathology Organosilicon Compounds - chemistry Organosilicon Compounds - therapeutic use Photochemicals Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - therapeutic use Phototoxicity Polyhedral oligomeric silsesquioxane Polymerization porphyrin Porphyrins - chemistry Porphyrins - therapeutic use POSS self-assembly Singlet oxygen Singlet Oxygen - chemistry |
| title | Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer |
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