Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyurea

Several single nucleotide polymorphisms (SNPs) influencing DNA repair capacity and apoptotic status may confer genetic predisposition to Philadelphia‑chromosome negative myeloproliferative neoplasms (PN‑MPNs), and influence therapeutic response and the clinical course. In the present study, whether...

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Veröffentlicht in:	Molecular medicine reports 2018-12, Vol.18 (6), p.5243-5255
Hauptverfasser:	Azevedo, Ana P, Silva, Susana N, Reichert, Alice, Lima, Fernando, Júnior, Esmeraldina, Rueff, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Apoptosis Base excision repair Biomarkers Caspase Caspases - metabolism Confidence intervals Deoxyribonucleic acid Disease DNA DNA damage DNA Repair Drug development Female Humans Hydroxyurea Hydroxyurea - therapeutic use Janus kinase 2 Janus Kinase 2 - genetics Male Middle Aged Mutation Myelofibrosis Myeloproliferative Disorders - drug therapy Myeloproliferative Disorders - genetics Myeloproliferative Disorders - metabolism Myeloproliferative Disorders - mortality Pathophysiology Patients Polymorphism, Single Nucleotide Risk Factors Signal Transduction Single-nucleotide polymorphism Thrombosis Thrombosis - etiology Treatment Outcome Tumors XRCC1 protein
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