Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology
Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational, prospective study enrolled 40 consecuti...
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Veröffentlicht in: | Neurobiology of aging 2019-01, Vol.73, p.61-67 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational, prospective study enrolled 40 consecutive nondemented adults diagnosed with LOEU, together with 43 age- and sex-matched healthy controls. All patients completed neuropsychological tests, core CSF AD biomarkers assessment (Aβ1-42, total tau, and phosphorylated tau), and follow-up for a mean of 3 years to verify cognitive decline. Despite age and baseline cognitive performance were similar to healthy controls, patients with LOEU had significant prevalence of CSF pathological Aβ1-42 ( |
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ISSN: | 0197-4580 1558-1497 |
DOI: | 10.1016/j.neurobiolaging.2018.09.006 |