Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology

Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational, prospective study enrolled 40 consecuti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurobiology of aging 2019-01, Vol.73, p.61-67
Hauptverfasser: Costa, Cinzia, Romoli, Michele, Liguori, Claudio, Farotti, Lucia, Eusebi, Paolo, Bedetti, Chiara, Siliquini, Sabrina, Cesarini, Elena Nardi, Romigi, Andrea, Mercuri, Nicola B., Parnetti, Lucilla, Calabresi, Paolo
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Although amyloid pathology plays a role in epilepsy, little is known about the relationship between beta amyloid and progression to Alzheimer's disease (AD) among patients with late-onset epilepsy of unknown origin (LOEU). This multicenter, observational, prospective study enrolled 40 consecutive nondemented adults diagnosed with LOEU, together with 43 age- and sex-matched healthy controls. All patients completed neuropsychological tests, core CSF AD biomarkers assessment (Aβ1-42, total tau, and phosphorylated tau), and follow-up for a mean of 3 years to verify cognitive decline. Despite age and baseline cognitive performance were similar to healthy controls, patients with LOEU had significant prevalence of CSF pathological Aβ1-42 (
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2018.09.006