Lipidic prodrug approach for improved oral drug delivery and therapy

In the past, a prodrug design was used as a last option to improve bioavailability through controlling transport, distribution, metabolism, or other mechanisms. Prodrugs are currently used even in early stages of drug development, and a significant percentage of all drugs in the market are prodrugs....

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Veröffentlicht in:	Medicinal research reviews 2019-03, Vol.39 (2), p.579-607
Hauptverfasser:	Markovic, Milica, Ben‐Shabat, Shimon, Keinan, Shahar, Aponick, Aaron, Zimmermann, Ellen M., Dahan, Arik
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability biopharmaceutics cholesterol drug bioavailability Drug delivery systems Drug development fatty acids (FA) Lipids lymphatic drug transport Metabolism oral drug delivery phospholipids (PL) prodrugs triglycerides (TG)
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