Safety and Pharmacokinetics of Oral Voriconazole in Patients at Risk of Fungal Infection: A Dose Escalation Study

The objective of this study was to investigate the safety, tolerability, and pharmacokinetics of oral voriconazole in subjects at high risk of developing fungal infections. This was a multicenter, randomized, double-blind, double-dummy, parallel-group, dose escalation study with a fluconazole active...

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Veröffentlicht in:	Journal of clinical pharmacology 2002-04, Vol.42 (4), p.395-402
Hauptverfasser:	Lazarus, Hillard M, Blumer, Jeffrey L, Yanovich, Saul, Schlamm, Haran, Romero, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - adverse effects Antifungal Agents - pharmacokinetics Biological and medical sciences Dose-Response Relationship, Drug Double-Blind Method Female Graft Rejection - complications Graft Rejection - drug therapy Hematologic Neoplasms - complications Hematologic Neoplasms - drug therapy Humans Male Medical sciences Middle Aged Mycoses - drug therapy Mycoses - etiology Neoplasms - complications Neoplasms - drug therapy Pharmacology. Drug treatments Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - pharmacokinetics Risk Factors Triazoles - administration & dosage Triazoles - adverse effects Triazoles - pharmacokinetics Voriconazole
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