Effects of Benzoylecgonine on the Behavior of Suckling Rats: A Preliminary Report

A major metabolite of cocaine, benzoylecgonine, causes behavioral activation that progresses to seizures when given intraventricularly to 2-week-old rats. The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperi...

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Veröffentlicht in:	Journal of child neurology 1992-01, Vol.7 (1), p.87-92
Hauptverfasser:	Konkol, Richard J., Doerr, Julie K., Madden, Jane A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Suckling - physiology Anticonvulsants - administration & dosage Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Behavior, Animal - drug effects Behavior, Animal - physiology Brain - drug effects Brain - metabolism Cocaine - analogs & derivatives Cocaine - metabolism Cocaine - pharmacology Cocaine - toxicity Female Humans Male Rats Rats, Inbred Strains Seizures - chemically induced Seizures - prevention & control
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