Effects of Benzoylecgonine on the Behavior of Suckling Rats: A Preliminary Report
A major metabolite of cocaine, benzoylecgonine, causes behavioral activation that progresses to seizures when given intraventricularly to 2-week-old rats. The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperi...
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| Veröffentlicht in: | Journal of child neurology 1992-01, Vol.7 (1), p.87-92 |
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| container_title | Journal of child neurology |
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| creator | Konkol, Richard J. Doerr, Julie K. Madden, Jane A. |
| description | A major metabolite of cocaine, benzoylecgonine, causes behavioral activation that progresses to seizures when given intraventricularly to 2-week-old rats. The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperidol, at a dose aimed at blocking stereotyped behavior, did not suppress these behaviors. In contrast, seizures were prevented by antiepileptic drugs, with the order of potency being diazepam > phenobarbital > phenytoin. We hypothesize that the long-lasting cocaine metabolite, benzoylecgonine, contributes to the infant cocaine intoxication syndrome. (J Child Neurol 1992;7:87-92). |
| doi_str_mv | 10.1177/088307389200700115 |
| format | Article |
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The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperidol, at a dose aimed at blocking stereotyped behavior, did not suppress these behaviors. In contrast, seizures were prevented by antiepileptic drugs, with the order of potency being diazepam > phenobarbital > phenytoin. We hypothesize that the long-lasting cocaine metabolite, benzoylecgonine, contributes to the infant cocaine intoxication syndrome. 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The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperidol, at a dose aimed at blocking stereotyped behavior, did not suppress these behaviors. In contrast, seizures were prevented by antiepileptic drugs, with the order of potency being diazepam > phenobarbital > phenytoin. We hypothesize that the long-lasting cocaine metabolite, benzoylecgonine, contributes to the infant cocaine intoxication syndrome. 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| fulltext | fulltext |
| identifier | ISSN: 0883-0738 |
| ispartof | Journal of child neurology, 1992-01, Vol.7 (1), p.87-92 |
| issn | 0883-0738 1708-8283 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Animals Animals, Suckling - physiology Anticonvulsants - administration & dosage Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Behavior, Animal - drug effects Behavior, Animal - physiology Brain - drug effects Brain - metabolism Cocaine - analogs & derivatives Cocaine - metabolism Cocaine - pharmacology Cocaine - toxicity Female Humans Male Rats Rats, Inbred Strains Seizures - chemically induced Seizures - prevention & control |
| title | Effects of Benzoylecgonine on the Behavior of Suckling Rats: A Preliminary Report |
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