Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury

Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated strategies to increase myelination of regenerating axons by overexpression of p...

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Veröffentlicht in:	Biotechnology and bioengineering 2019-01, Vol.116 (1), p.155-167
Hauptverfasser:	Smith, Dominique R., Margul, Daniel J., Dumont, Courtney M., Carlson, Mitchell A., Munsell, Mary K., Johnson, Mitchell, Cummings, Brian J., Anderson, Aileen J., Shea, Lonnie D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Carrier Proteins - administration & dosage Carrier Proteins - genetics Combinatorial analysis Disease Models, Animal Drug Carriers - administration & dosage gene therapy Gene transfer Genetic Therapy - methods Genetic Vectors Growth factors Injuries Lentivirus - genetics Mice Myelin Myelin Sheath - drug effects Myelination Nerve Regeneration Noggin protein Paralysis Platelet-derived growth factor Platelet-Derived Growth Factor - administration & dosage Platelet-Derived Growth Factor - genetics Recovery Recovery of function Regenerative Medicine - methods Regrowth Spinal cord injuries Spinal Cord Injuries - therapy spinal cord injury (SCI) tissue engineering Treatment Outcome
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