Hormonal mechanisms regulating follicular wave dynamics I: Comparison of follicle growth profiles under different physiological conditions in heifers
Follicle diameter deviation has been identified as the pivotal morphological manifestation of follicle selection, however, many of the hormonal mechanisms leading to this key event and regulating variation between individual follicular waves remain undefined. This study compared circulating FSH, LH,...
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| Veröffentlicht in: | Theriogenology 2019-01, Vol.123, p.194-201 |
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| description | Follicle diameter deviation has been identified as the pivotal morphological manifestation of follicle selection, however, many of the hormonal mechanisms leading to this key event and regulating variation between individual follicular waves remain undefined. This study compared circulating FSH, LH, and P4 with the follicular dynamics during three different physiological conditions. We hypothesized that these end-points would: 1) be similar for a spontaneous wave 2 vs one induced by follicular aspiration, 2) but would differ between wave 1 and 2, and 3) between conventional (F2 > 7.0 mm at deviation) vs undersized (F2 |
| doi_str_mv | 10.1016/j.theriogenology.2018.09.006 |
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•Induced follicular waves have greater FSH surge but similar follicle growth dynamics.•Wave 1 & 2 have similar dominant (F1) but different subordinate (F2) follicle growth.•FSH & F2 differences wane when classified as conventional or undersized deviations.•Undersized deviations have slower F2 growth but greater FSH than conventional.•Conventional vs undersized deviation classes help explain follicular dynamics.]]></description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/j.theriogenology.2018.09.006</identifier><identifier>PMID: 30316127</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cattle - physiology ; Diameter complexities ; Diameter deviation ; Female ; Follicle selection ; Follicle Stimulating Hormone - blood ; Luteinizing Hormone - blood ; Ovarian Follicle - physiology ; Progesterone - blood ; Random Allocation ; Wave synchronization</subject><ispartof>Theriogenology, 2019-01, Vol.123, p.194-201</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-fae61f9d66135b7c42921b3076435aa766cf53723d4e5a4e323d3479bbbdaec93</citedby><cites>FETCH-LOGICAL-c386t-fae61f9d66135b7c42921b3076435aa766cf53723d4e5a4e323d3479bbbdaec93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093691X18307799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30316127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez-León, V.E.</creatorcontrib><creatorcontrib>Ginther, O.J.</creatorcontrib><creatorcontrib>Araujo, E.R.</creatorcontrib><creatorcontrib>Guimarães, J.D.</creatorcontrib><creatorcontrib>Wiltbank, M.C.</creatorcontrib><title>Hormonal mechanisms regulating follicular wave dynamics I: Comparison of follicle growth profiles under different physiological conditions in heifers</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description><![CDATA[Follicle diameter deviation has been identified as the pivotal morphological manifestation of follicle selection, however, many of the hormonal mechanisms leading to this key event and regulating variation between individual follicular waves remain undefined. This study compared circulating FSH, LH, and P4 with the follicular dynamics during three different physiological conditions. We hypothesized that these end-points would: 1) be similar for a spontaneous wave 2 vs one induced by follicular aspiration, 2) but would differ between wave 1 and 2, and 3) between conventional (F2 > 7.0 mm at deviation) vs undersized (F2 < 7.0 mm) deviations in either wave. Holstein dairy heifers (N = 24) were studied daily during an interovulatory interval. All heifers were evaluated during wave 1 and randomized 6 days after ovulation into an induced wave 2 and a spontaneous wave 2. Values were normalized to the day of expected diameter deviation (day 0) and compared for day −2 to 0 and 0 to 2. Hypothesis 1 was supported that an induced wave 2 from ablation of follicles of wave 1 and spontaneous wave 2 have similar follicle dynamics. However, the peak FSH surge was more prominent at emergence of an induced wave 2 (P < 0.003). Hypothesis 2 was supported that waves 1 and 2 differ in follicle and hormone dynamics. Circulating P4 was lower and LH was greater (P < 0.01) with no difference in diameter of F1 but with a greater (P < 0.01) diameter of F2 on day 0 in wave 1 (7.3 ± 0.2 mm) than in wave 2 (6.6 ± 0.2 mm). Differences between waves were not found when each follicular wave was categorized into conventional vs undersized deviation and analyzed separately. Hypothesis 3 was supported as there were differences in circulating hormones between conventional and undersized deviations. Growth rate of F2 differed (P < 0.0005) during days −2 to 0 (conventional, 2.6 ± 0.2 mm/2d; undersized, 1.4 ± 0.3 mm/2d). However, circulating FSH and P4 concentration on days −1 and 0 tended to be greater (P < 0.06) in undersized than conventional deviations. In conclusion, the effect of different hormonal conditions on follicle dynamics was observed for F2 and not for F1. Furthermore, understanding the physiology that produces conventional vs undersized deviations is crucial since these categories explained most differences in follicular dynamics and circulating FSH observed in these different physiological conditions. In addition, future studies of wave 2 may be facilitated by using an induced wave 2 since it was similar to a spontaneous wave 2.
•Induced follicular waves have greater FSH surge but similar follicle growth dynamics.•Wave 1 & 2 have similar dominant (F1) but different subordinate (F2) follicle growth.•FSH & F2 differences wane when classified as conventional or undersized deviations.•Undersized deviations have slower F2 growth but greater FSH than conventional.•Conventional vs undersized deviation classes help explain follicular dynamics.]]></description><subject>Animals</subject><subject>Cattle - physiology</subject><subject>Diameter complexities</subject><subject>Diameter deviation</subject><subject>Female</subject><subject>Follicle selection</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Luteinizing Hormone - blood</subject><subject>Ovarian Follicle - physiology</subject><subject>Progesterone - blood</subject><subject>Random Allocation</subject><subject>Wave synchronization</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGO0zAQhiMEYsvCKyAfOHBJsOPUqREXVLHsSitxAYmb5djjZCrHLna6qz7Ivi-uWpC4cRqN9I3_GX9V9Y7RhlEmPuyaZYKEcYQQfRyPTUvZpqGyoVQ8q1Zs08uat5w9r1aUSl4LyX5eVa9y3lFKuRDsZXXFKWeCtf2qerqNaY5BezKDmXTAPGeSYDx4vWAYiYveoyldIo_6AYg9Bj2jyeTuI9nGea8T5hhIdBfSAxlTfFwmsk_RoYdMDsFCIhadgwRhIfvpmPG0OpoSa2KwuGAMmWAgE2Ch8uvqhdM-w5tLva5-3Hz5vr2t7799vdt-vq8N34ildhoEc9KWo_h66E3XypYNnPai42uteyGMW_O-5baDte6gfIvlXS-HYbAajOTX1fvzu2XZXwfIi5oxG_BeB4iHrFrGpOTdpu0K-umMmhRzTuDUPuGs01Exqk5i1E79K0adxCgqVRFTxt9ekg7DDPbv8B8TBbg5A1DufUBIKhuEYMBiArMoG_H_kn4D5WWs_Q</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Gomez-León, V.E.</creator><creator>Ginther, O.J.</creator><creator>Araujo, E.R.</creator><creator>Guimarães, J.D.</creator><creator>Wiltbank, M.C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Hormonal mechanisms regulating follicular wave dynamics I: Comparison of follicle growth profiles under different physiological conditions in heifers</title><author>Gomez-León, V.E. ; Ginther, O.J. ; Araujo, E.R. ; Guimarães, J.D. ; Wiltbank, M.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-fae61f9d66135b7c42921b3076435aa766cf53723d4e5a4e323d3479bbbdaec93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Cattle - physiology</topic><topic>Diameter complexities</topic><topic>Diameter deviation</topic><topic>Female</topic><topic>Follicle selection</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Luteinizing Hormone - blood</topic><topic>Ovarian Follicle - physiology</topic><topic>Progesterone - blood</topic><topic>Random Allocation</topic><topic>Wave synchronization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez-León, V.E.</creatorcontrib><creatorcontrib>Ginther, O.J.</creatorcontrib><creatorcontrib>Araujo, E.R.</creatorcontrib><creatorcontrib>Guimarães, J.D.</creatorcontrib><creatorcontrib>Wiltbank, M.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez-León, V.E.</au><au>Ginther, O.J.</au><au>Araujo, E.R.</au><au>Guimarães, J.D.</au><au>Wiltbank, M.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal mechanisms regulating follicular wave dynamics I: Comparison of follicle growth profiles under different physiological conditions in heifers</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>123</volume><spage>194</spage><epage>201</epage><pages>194-201</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract><![CDATA[Follicle diameter deviation has been identified as the pivotal morphological manifestation of follicle selection, however, many of the hormonal mechanisms leading to this key event and regulating variation between individual follicular waves remain undefined. This study compared circulating FSH, LH, and P4 with the follicular dynamics during three different physiological conditions. We hypothesized that these end-points would: 1) be similar for a spontaneous wave 2 vs one induced by follicular aspiration, 2) but would differ between wave 1 and 2, and 3) between conventional (F2 > 7.0 mm at deviation) vs undersized (F2 < 7.0 mm) deviations in either wave. Holstein dairy heifers (N = 24) were studied daily during an interovulatory interval. All heifers were evaluated during wave 1 and randomized 6 days after ovulation into an induced wave 2 and a spontaneous wave 2. Values were normalized to the day of expected diameter deviation (day 0) and compared for day −2 to 0 and 0 to 2. Hypothesis 1 was supported that an induced wave 2 from ablation of follicles of wave 1 and spontaneous wave 2 have similar follicle dynamics. However, the peak FSH surge was more prominent at emergence of an induced wave 2 (P < 0.003). Hypothesis 2 was supported that waves 1 and 2 differ in follicle and hormone dynamics. Circulating P4 was lower and LH was greater (P < 0.01) with no difference in diameter of F1 but with a greater (P < 0.01) diameter of F2 on day 0 in wave 1 (7.3 ± 0.2 mm) than in wave 2 (6.6 ± 0.2 mm). Differences between waves were not found when each follicular wave was categorized into conventional vs undersized deviation and analyzed separately. Hypothesis 3 was supported as there were differences in circulating hormones between conventional and undersized deviations. Growth rate of F2 differed (P < 0.0005) during days −2 to 0 (conventional, 2.6 ± 0.2 mm/2d; undersized, 1.4 ± 0.3 mm/2d). However, circulating FSH and P4 concentration on days −1 and 0 tended to be greater (P < 0.06) in undersized than conventional deviations. In conclusion, the effect of different hormonal conditions on follicle dynamics was observed for F2 and not for F1. Furthermore, understanding the physiology that produces conventional vs undersized deviations is crucial since these categories explained most differences in follicular dynamics and circulating FSH observed in these different physiological conditions. In addition, future studies of wave 2 may be facilitated by using an induced wave 2 since it was similar to a spontaneous wave 2.
•Induced follicular waves have greater FSH surge but similar follicle growth dynamics.•Wave 1 & 2 have similar dominant (F1) but different subordinate (F2) follicle growth.•FSH & F2 differences wane when classified as conventional or undersized deviations.•Undersized deviations have slower F2 growth but greater FSH than conventional.•Conventional vs undersized deviation classes help explain follicular dynamics.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30316127</pmid><doi>10.1016/j.theriogenology.2018.09.006</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Cattle - physiology Diameter complexities Diameter deviation Female Follicle selection Follicle Stimulating Hormone - blood Luteinizing Hormone - blood Ovarian Follicle - physiology Progesterone - blood Random Allocation Wave synchronization |
| title | Hormonal mechanisms regulating follicular wave dynamics I: Comparison of follicle growth profiles under different physiological conditions in heifers |
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