Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model
Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation. Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of applicati...
Gespeichert in:
| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 2018-12, Vol.189, p.49-54 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 54 |
|---|---|
| container_issue | |
| container_start_page | 49 |
| container_title | Journal of photochemistry and photobiology. B, Biology |
| container_volume | 189 |
| creator | Pedram, Mir Sepehr Dehghan, Mohammad Mehdi Shojaee, Maryam Fekrazad, Reza Sharifi, Davood Farzan, Arash Ghasemi, Setareh AliMohammad Kalhori, Katayoun |
| description | Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation.
Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of application of each of them separately.
The study was conducted at the Department of Surgery & Radiology, Faculty of Veterinary Medicine and Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Twenty four rats were used in this study. A compression injury was induced to the T8-T9 segment of the spinal cord of rats using a Fogarty embolectomy catheter. Rats were randomly divided into 4 groups including: Control group, PBMT (810 nm-200 mw-8 s-2 weeks) group, Meloxicam (1 mg/kg) group, and PBMT and Meloxicam (mixed) group. After inducing injury, hind limb performance of the rats was evaluated, using BBB test and then treatment intervention was performed and continued for 2 weeks.
Four weeks after injury induction, BBB test results were significantly higher in all treatment groups in comparison to control group, however, there were no significant differences among the treatment groups. In addition, histological findings revealed no significant difference between all 4 study groups.
According to the results of this study we can conclude that simultaneous and separate application of PBMT and Meloxicam play an effective role in treatment of acute spinal cord injuries.
•Administration of meloxicam can improve clinical features after spinal cord injury.•Using PBMT can improve functional activity of rats suffered from SCI.•Simultaneous application of PBMT and Meloxicam play effective role in treatment of SCI |
| doi_str_mv | 10.1016/j.jphotobiol.2018.09.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2119930015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1011134418305712</els_id><sourcerecordid>2119930015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-75663c25b067c76e146476287826a7b20ff6c499d7a6f442f2f60326c9e5452a3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS1ERX_gFZAlNmWRYDuOnbCjFRSkVq3QsLY8zrXqKImD7VSdh-Fd8TQDSGxqWfKPvnOP7j0IYUpKSqj40Jf9fO-T3zo_lIzQpiRtSRh7gU5oI6uCiYa9zHdCaUErzo_RaYw9yasW8hU6rkhFWcvICfq1uYegZ1iSMxisBZMi9hZHNy5D0hP4JeK7g9fou2XQyfkJpyfZDp_fXdxs3mM9dfgGBv_ojB6x7kY3uZjCyuYNjzMEN8KU9IC1WRLgOLspP4wPHXZTv4TdR_xdp1zKjfk_e8HwGh1ZPUR4czjP0I8vnzeXX4vr26tvl5-uC8MJS4WshagMq7dESCMFUC64FKyRDRNabhmxVhjetp3UwnLOLLOCVEyYFmpeM12dofO17hz8zwViUqOLBoZhHYBilLZtRQitM_ruP7T3S8id7CmRq9WkbTLVrJQJPsYAVs25fR12ihK1j1D16l-Eah-hIq3KEWbp24PBsh2h-yv8k1kGLlYA8kQeHAQVjYPJQOdCjk913j3v8ht9H7QZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2164525098</pqid></control><display><type>article</type><title>Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Pedram, Mir Sepehr ; Dehghan, Mohammad Mehdi ; Shojaee, Maryam ; Fekrazad, Reza ; Sharifi, Davood ; Farzan, Arash ; Ghasemi, Setareh ; AliMohammad Kalhori, Katayoun</creator><creatorcontrib>Pedram, Mir Sepehr ; Dehghan, Mohammad Mehdi ; Shojaee, Maryam ; Fekrazad, Reza ; Sharifi, Davood ; Farzan, Arash ; Ghasemi, Setareh ; AliMohammad Kalhori, Katayoun</creatorcontrib><description>Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation.
Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of application of each of them separately.
The study was conducted at the Department of Surgery & Radiology, Faculty of Veterinary Medicine and Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Twenty four rats were used in this study. A compression injury was induced to the T8-T9 segment of the spinal cord of rats using a Fogarty embolectomy catheter. Rats were randomly divided into 4 groups including: Control group, PBMT (810 nm-200 mw-8 s-2 weeks) group, Meloxicam (1 mg/kg) group, and PBMT and Meloxicam (mixed) group. After inducing injury, hind limb performance of the rats was evaluated, using BBB test and then treatment intervention was performed and continued for 2 weeks.
Four weeks after injury induction, BBB test results were significantly higher in all treatment groups in comparison to control group, however, there were no significant differences among the treatment groups. In addition, histological findings revealed no significant difference between all 4 study groups.
According to the results of this study we can conclude that simultaneous and separate application of PBMT and Meloxicam play an effective role in treatment of acute spinal cord injuries.
•Administration of meloxicam can improve clinical features after spinal cord injury.•Using PBMT can improve functional activity of rats suffered from SCI.•Simultaneous application of PBMT and Meloxicam play effective role in treatment of SCI</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2018.09.022</identifier><identifier>PMID: 30312920</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; BBB test ; Combined Modality Therapy - methods ; Compression ; Effects ; Evaluation ; Experiments ; Injuries ; Light therapy ; Low-Level Light Therapy - methods ; Medical instruments ; Meloxicam ; Meloxicam - therapeutic use ; NSAIDs ; Photobiomodulation therapy (PBMT) ; Radiology ; Rats ; Recovery of function ; Rodents ; Spinal cord injuries ; Spinal Cord Injuries - therapy ; Spinal cord injury ; Surgery ; Therapy ; Treatment Outcome ; Veterinary ; Veterinary medicine</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 2018-12, Vol.189, p.49-54</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Dec 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-75663c25b067c76e146476287826a7b20ff6c499d7a6f442f2f60326c9e5452a3</citedby><cites>FETCH-LOGICAL-c402t-75663c25b067c76e146476287826a7b20ff6c499d7a6f442f2f60326c9e5452a3</cites><orcidid>0000-0002-8825-9070</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1011134418305712$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30312920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedram, Mir Sepehr</creatorcontrib><creatorcontrib>Dehghan, Mohammad Mehdi</creatorcontrib><creatorcontrib>Shojaee, Maryam</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Sharifi, Davood</creatorcontrib><creatorcontrib>Farzan, Arash</creatorcontrib><creatorcontrib>Ghasemi, Setareh</creatorcontrib><creatorcontrib>AliMohammad Kalhori, Katayoun</creatorcontrib><title>Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation.
Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of application of each of them separately.
The study was conducted at the Department of Surgery & Radiology, Faculty of Veterinary Medicine and Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Twenty four rats were used in this study. A compression injury was induced to the T8-T9 segment of the spinal cord of rats using a Fogarty embolectomy catheter. Rats were randomly divided into 4 groups including: Control group, PBMT (810 nm-200 mw-8 s-2 weeks) group, Meloxicam (1 mg/kg) group, and PBMT and Meloxicam (mixed) group. After inducing injury, hind limb performance of the rats was evaluated, using BBB test and then treatment intervention was performed and continued for 2 weeks.
Four weeks after injury induction, BBB test results were significantly higher in all treatment groups in comparison to control group, however, there were no significant differences among the treatment groups. In addition, histological findings revealed no significant difference between all 4 study groups.
According to the results of this study we can conclude that simultaneous and separate application of PBMT and Meloxicam play an effective role in treatment of acute spinal cord injuries.
•Administration of meloxicam can improve clinical features after spinal cord injury.•Using PBMT can improve functional activity of rats suffered from SCI.•Simultaneous application of PBMT and Meloxicam play effective role in treatment of SCI</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>BBB test</subject><subject>Combined Modality Therapy - methods</subject><subject>Compression</subject><subject>Effects</subject><subject>Evaluation</subject><subject>Experiments</subject><subject>Injuries</subject><subject>Light therapy</subject><subject>Low-Level Light Therapy - methods</subject><subject>Medical instruments</subject><subject>Meloxicam</subject><subject>Meloxicam - therapeutic use</subject><subject>NSAIDs</subject><subject>Photobiomodulation therapy (PBMT)</subject><subject>Radiology</subject><subject>Rats</subject><subject>Recovery of function</subject><subject>Rodents</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - therapy</subject><subject>Spinal cord injury</subject><subject>Surgery</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><subject>Veterinary</subject><subject>Veterinary medicine</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1ERX_gFZAlNmWRYDuOnbCjFRSkVq3QsLY8zrXqKImD7VSdh-Fd8TQDSGxqWfKPvnOP7j0IYUpKSqj40Jf9fO-T3zo_lIzQpiRtSRh7gU5oI6uCiYa9zHdCaUErzo_RaYw9yasW8hU6rkhFWcvICfq1uYegZ1iSMxisBZMi9hZHNy5D0hP4JeK7g9fou2XQyfkJpyfZDp_fXdxs3mM9dfgGBv_ojB6x7kY3uZjCyuYNjzMEN8KU9IC1WRLgOLspP4wPHXZTv4TdR_xdp1zKjfk_e8HwGh1ZPUR4czjP0I8vnzeXX4vr26tvl5-uC8MJS4WshagMq7dESCMFUC64FKyRDRNabhmxVhjetp3UwnLOLLOCVEyYFmpeM12dofO17hz8zwViUqOLBoZhHYBilLZtRQitM_ruP7T3S8id7CmRq9WkbTLVrJQJPsYAVs25fR12ihK1j1D16l-Eah-hIq3KEWbp24PBsh2h-yv8k1kGLlYA8kQeHAQVjYPJQOdCjk913j3v8ht9H7QZ</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Pedram, Mir Sepehr</creator><creator>Dehghan, Mohammad Mehdi</creator><creator>Shojaee, Maryam</creator><creator>Fekrazad, Reza</creator><creator>Sharifi, Davood</creator><creator>Farzan, Arash</creator><creator>Ghasemi, Setareh</creator><creator>AliMohammad Kalhori, Katayoun</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8825-9070</orcidid></search><sort><creationdate>201812</creationdate><title>Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model</title><author>Pedram, Mir Sepehr ; Dehghan, Mohammad Mehdi ; Shojaee, Maryam ; Fekrazad, Reza ; Sharifi, Davood ; Farzan, Arash ; Ghasemi, Setareh ; AliMohammad Kalhori, Katayoun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-75663c25b067c76e146476287826a7b20ff6c499d7a6f442f2f60326c9e5452a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>BBB test</topic><topic>Combined Modality Therapy - methods</topic><topic>Compression</topic><topic>Effects</topic><topic>Evaluation</topic><topic>Experiments</topic><topic>Injuries</topic><topic>Light therapy</topic><topic>Low-Level Light Therapy - methods</topic><topic>Medical instruments</topic><topic>Meloxicam</topic><topic>Meloxicam - therapeutic use</topic><topic>NSAIDs</topic><topic>Photobiomodulation therapy (PBMT)</topic><topic>Radiology</topic><topic>Rats</topic><topic>Recovery of function</topic><topic>Rodents</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - therapy</topic><topic>Spinal cord injury</topic><topic>Surgery</topic><topic>Therapy</topic><topic>Treatment Outcome</topic><topic>Veterinary</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedram, Mir Sepehr</creatorcontrib><creatorcontrib>Dehghan, Mohammad Mehdi</creatorcontrib><creatorcontrib>Shojaee, Maryam</creatorcontrib><creatorcontrib>Fekrazad, Reza</creatorcontrib><creatorcontrib>Sharifi, Davood</creatorcontrib><creatorcontrib>Farzan, Arash</creatorcontrib><creatorcontrib>Ghasemi, Setareh</creatorcontrib><creatorcontrib>AliMohammad Kalhori, Katayoun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedram, Mir Sepehr</au><au>Dehghan, Mohammad Mehdi</au><au>Shojaee, Maryam</au><au>Fekrazad, Reza</au><au>Sharifi, Davood</au><au>Farzan, Arash</au><au>Ghasemi, Setareh</au><au>AliMohammad Kalhori, Katayoun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2018-12</date><risdate>2018</risdate><volume>189</volume><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><abstract>Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation.
Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of application of each of them separately.
The study was conducted at the Department of Surgery & Radiology, Faculty of Veterinary Medicine and Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Twenty four rats were used in this study. A compression injury was induced to the T8-T9 segment of the spinal cord of rats using a Fogarty embolectomy catheter. Rats were randomly divided into 4 groups including: Control group, PBMT (810 nm-200 mw-8 s-2 weeks) group, Meloxicam (1 mg/kg) group, and PBMT and Meloxicam (mixed) group. After inducing injury, hind limb performance of the rats was evaluated, using BBB test and then treatment intervention was performed and continued for 2 weeks.
Four weeks after injury induction, BBB test results were significantly higher in all treatment groups in comparison to control group, however, there were no significant differences among the treatment groups. In addition, histological findings revealed no significant difference between all 4 study groups.
According to the results of this study we can conclude that simultaneous and separate application of PBMT and Meloxicam play an effective role in treatment of acute spinal cord injuries.
•Administration of meloxicam can improve clinical features after spinal cord injury.•Using PBMT can improve functional activity of rats suffered from SCI.•Simultaneous application of PBMT and Meloxicam play effective role in treatment of SCI</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>30312920</pmid><doi>10.1016/j.jphotobiol.2018.09.022</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8825-9070</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1011-1344 |
| ispartof | Journal of photochemistry and photobiology. B, Biology, 2018-12, Vol.189, p.49-54 |
| issn | 1011-1344 1873-2682 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2119930015 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use BBB test Combined Modality Therapy - methods Compression Effects Evaluation Experiments Injuries Light therapy Low-Level Light Therapy - methods Medical instruments Meloxicam Meloxicam - therapeutic use NSAIDs Photobiomodulation therapy (PBMT) Radiology Rats Recovery of function Rodents Spinal cord injuries Spinal Cord Injuries - therapy Spinal cord injury Surgery Therapy Treatment Outcome Veterinary Veterinary medicine |
| title | Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A15%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20effects%20of%20simultaneous%20Photobiomodulation%20therapy%20(PBMT)%20and%20Meloxicam%20administration%20on%20experimental%20acute%20spinal%20cord%20injury:%20Rat%20animal%20model&rft.jtitle=Journal%20of%20photochemistry%20and%20photobiology.%20B,%20Biology&rft.au=Pedram,%20Mir%20Sepehr&rft.date=2018-12&rft.volume=189&rft.spage=49&rft.epage=54&rft.pages=49-54&rft.issn=1011-1344&rft.eissn=1873-2682&rft_id=info:doi/10.1016/j.jphotobiol.2018.09.022&rft_dat=%3Cproquest_cross%3E2119930015%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2164525098&rft_id=info:pmid/30312920&rft_els_id=S1011134418305712&rfr_iscdi=true |