Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with...

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Veröffentlicht in:	Neurobiology of aging 2019-01, Vol.73, p.9-20
Hauptverfasser:	Babiloni, Claudio, Del Percio, Claudio, Lizio, Roberta, Noce, Giuseppe, Lopez, Susanna, Soricelli, Andrea, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco, Bonanni, Laura, Franciotti, Raffaella, Onofrj, Marco, Stirpe, Paola, Fuhr, Peter, Gschwandtner, Ute, Ransmayr, Gerhard, Fraioli, Lucia, Parnetti, Lucilla, Farotti, Lucia, Pievani, Michela, D'Antonio, Fabrizia, De Lena, Carlo, Güntekin, Bahar, Hanoğlu, Lutfu, Yener, Görsev, Emek-Savaş, Derya Durusu, Triggiani, Antonio Ivano, Taylor, John Paul, McKeith, Ian, Stocchi, Fabrizio, Vacca, Laura, Frisoni, Giovanni B., De Pandis, Maria Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiparkinson Agents - pharmacology Antiparkinson Agents - therapeutic use Cerebral Cortex - physiopathology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Electroencephalography - drug effects Female Functional brain connectivity Humans Levodopa - pharmacology Levodopa - therapeutic use Male Mild cognitive impairment due to Alzheimer's disease (ADMCI) Mild cognitive impairment due to Parkinson's disease (PDMCI) Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson Disease - physiopathology Rest - physiology Resting state EEG rhythms
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