Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms
We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with...
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| Veröffentlicht in: | Neurobiology of aging 2019-01, Vol.73, p.9-20 |
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| creator | Babiloni, Claudio Del Percio, Claudio Lizio, Roberta Noce, Giuseppe Lopez, Susanna Soricelli, Andrea Ferri, Raffaele Pascarelli, Maria Teresa Catania, Valentina Nobili, Flavio Arnaldi, Dario Famà, Francesco Orzi, Francesco Buttinelli, Carla Giubilei, Franco Bonanni, Laura Franciotti, Raffaella Onofrj, Marco Stirpe, Paola Fuhr, Peter Gschwandtner, Ute Ransmayr, Gerhard Fraioli, Lucia Parnetti, Lucilla Farotti, Lucia Pievani, Michela D'Antonio, Fabrizia De Lena, Carlo Güntekin, Bahar Hanoğlu, Lutfu Yener, Görsev Emek-Savaş, Derya Durusu Triggiani, Antonio Ivano Taylor, John Paul McKeith, Ian Stocchi, Fabrizio Vacca, Laura Frisoni, Giovanni B. De Pandis, Maria Francesca |
| description | We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta ( |
| doi_str_mv | 10.1016/j.neurobiolaging.2018.08.010 |
| format | Article |
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Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2018.08.010</identifier><identifier>PMID: 30312790</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Antiparkinson Agents - pharmacology ; Antiparkinson Agents - therapeutic use ; Cerebral Cortex - physiopathology ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Electroencephalography - drug effects ; Female ; Functional brain connectivity ; Humans ; Levodopa - pharmacology ; Levodopa - therapeutic use ; Male ; Mild cognitive impairment due to Alzheimer's disease (ADMCI) ; Mild cognitive impairment due to Parkinson's disease (PDMCI) ; Parkinson Disease - complications ; Parkinson Disease - drug therapy ; Parkinson Disease - physiopathology ; Rest - physiology ; Resting state EEG rhythms</subject><ispartof>Neurobiology of aging, 2019-01, Vol.73, p.9-20</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-d0e936e29828206b68b980fa67b5b70912dbe46c2fb378633e236095cf2c1cbf3</citedby><cites>FETCH-LOGICAL-c412t-d0e936e29828206b68b980fa67b5b70912dbe46c2fb378633e236095cf2c1cbf3</cites><orcidid>0000-0001-7042-697X ; 0000-0001-6823-6069 ; 0000-0003-3291-9452 ; 0000-0001-9811-0897 ; 0000-0002-1794-8987 ; 0000-0001-6937-3065 ; 0000-0002-5245-9839 ; 0000-0001-7443-9233</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458018302938$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30312790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babiloni, Claudio</creatorcontrib><creatorcontrib>Del Percio, Claudio</creatorcontrib><creatorcontrib>Lizio, Roberta</creatorcontrib><creatorcontrib>Noce, Giuseppe</creatorcontrib><creatorcontrib>Lopez, Susanna</creatorcontrib><creatorcontrib>Soricelli, Andrea</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><creatorcontrib>Pascarelli, Maria Teresa</creatorcontrib><creatorcontrib>Catania, Valentina</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><creatorcontrib>Arnaldi, Dario</creatorcontrib><creatorcontrib>Famà, Francesco</creatorcontrib><creatorcontrib>Orzi, Francesco</creatorcontrib><creatorcontrib>Buttinelli, Carla</creatorcontrib><creatorcontrib>Giubilei, Franco</creatorcontrib><creatorcontrib>Bonanni, Laura</creatorcontrib><creatorcontrib>Franciotti, Raffaella</creatorcontrib><creatorcontrib>Onofrj, Marco</creatorcontrib><creatorcontrib>Stirpe, Paola</creatorcontrib><creatorcontrib>Fuhr, Peter</creatorcontrib><creatorcontrib>Gschwandtner, Ute</creatorcontrib><creatorcontrib>Ransmayr, Gerhard</creatorcontrib><creatorcontrib>Fraioli, Lucia</creatorcontrib><creatorcontrib>Parnetti, Lucilla</creatorcontrib><creatorcontrib>Farotti, Lucia</creatorcontrib><creatorcontrib>Pievani, Michela</creatorcontrib><creatorcontrib>D'Antonio, Fabrizia</creatorcontrib><creatorcontrib>De Lena, Carlo</creatorcontrib><creatorcontrib>Güntekin, Bahar</creatorcontrib><creatorcontrib>Hanoğlu, Lutfu</creatorcontrib><creatorcontrib>Yener, Görsev</creatorcontrib><creatorcontrib>Emek-Savaş, Derya Durusu</creatorcontrib><creatorcontrib>Triggiani, Antonio Ivano</creatorcontrib><creatorcontrib>Taylor, John Paul</creatorcontrib><creatorcontrib>McKeith, Ian</creatorcontrib><creatorcontrib>Stocchi, Fabrizio</creatorcontrib><creatorcontrib>Vacca, Laura</creatorcontrib><creatorcontrib>Frisoni, Giovanni B.</creatorcontrib><creatorcontrib>De Pandis, Maria Francesca</creatorcontrib><title>Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8–12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.</description><subject>Aged</subject><subject>Antiparkinson Agents - pharmacology</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Electroencephalography - drug effects</subject><subject>Female</subject><subject>Functional brain connectivity</subject><subject>Humans</subject><subject>Levodopa - pharmacology</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Mild cognitive impairment due to Alzheimer's disease (ADMCI)</subject><subject>Mild cognitive impairment due to Parkinson's disease (PDMCI)</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - drug therapy</subject><subject>Parkinson Disease - physiopathology</subject><subject>Rest - physiology</subject><subject>Resting state EEG rhythms</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUdGq1DAQLaJ416u_IHkQ9KVrkrZpC77I5V4VFvRBn0OSTraztk1N0tX-oN9lyl4V34SBGYZz5szMybIXjO4ZZeL1aT_B4p1GN6gjTsc9p6zZ0xSMPsh2rKqanJVt_TDbUdbWeVk19Cp7EsKJUlqXtXicXRW0YLxu6S77eYCz69ysyKhWoqwFE4lxPqJRA4EfBqPSOGBcCU7kk_JfcQpuehlIhwFUADKriDDFQL5j7BP1OGHEM5AOLCZ2ICoQD2dQA3REr6nuFpNKZRJsm-vsX8HgFm8gbD0PIabzSIgqAoEhLeYdTAbmXg3u6NXcoyG-X2M_hqfZI6uGAM_u83X25e728837_PDx3Yebt4fclIzHvKPQFgJ42_CGU6FFo9uGWiVqXematox3GkphuNVF3YiiAF4I2lbGcsOMtsV19uoyd_bu25I2lCMGA8OgJnBLkJyxtuW14EWCvrlAjXcheLBy9jgqv0pG5eakPMl_nZSbk5KmYDTRn98rLXqE7g_5t3UJcHcBQLr3jOBlMLj9p0OffiU7h_-n9AtS9L7V</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Babiloni, Claudio</creator><creator>Del Percio, Claudio</creator><creator>Lizio, Roberta</creator><creator>Noce, Giuseppe</creator><creator>Lopez, Susanna</creator><creator>Soricelli, Andrea</creator><creator>Ferri, Raffaele</creator><creator>Pascarelli, Maria Teresa</creator><creator>Catania, Valentina</creator><creator>Nobili, Flavio</creator><creator>Arnaldi, Dario</creator><creator>Famà, Francesco</creator><creator>Orzi, Francesco</creator><creator>Buttinelli, Carla</creator><creator>Giubilei, Franco</creator><creator>Bonanni, Laura</creator><creator>Franciotti, Raffaella</creator><creator>Onofrj, Marco</creator><creator>Stirpe, Paola</creator><creator>Fuhr, Peter</creator><creator>Gschwandtner, Ute</creator><creator>Ransmayr, Gerhard</creator><creator>Fraioli, Lucia</creator><creator>Parnetti, Lucilla</creator><creator>Farotti, Lucia</creator><creator>Pievani, Michela</creator><creator>D'Antonio, Fabrizia</creator><creator>De Lena, Carlo</creator><creator>Güntekin, Bahar</creator><creator>Hanoğlu, Lutfu</creator><creator>Yener, Görsev</creator><creator>Emek-Savaş, Derya Durusu</creator><creator>Triggiani, Antonio Ivano</creator><creator>Taylor, John Paul</creator><creator>McKeith, Ian</creator><creator>Stocchi, Fabrizio</creator><creator>Vacca, Laura</creator><creator>Frisoni, Giovanni B.</creator><creator>De Pandis, Maria Francesca</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7042-697X</orcidid><orcidid>https://orcid.org/0000-0001-6823-6069</orcidid><orcidid>https://orcid.org/0000-0003-3291-9452</orcidid><orcidid>https://orcid.org/0000-0001-9811-0897</orcidid><orcidid>https://orcid.org/0000-0002-1794-8987</orcidid><orcidid>https://orcid.org/0000-0001-6937-3065</orcidid><orcidid>https://orcid.org/0000-0002-5245-9839</orcidid><orcidid>https://orcid.org/0000-0001-7443-9233</orcidid></search><sort><creationdate>201901</creationdate><title>Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms</title><author>Babiloni, Claudio ; Del Percio, Claudio ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Soricelli, Andrea ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Catania, Valentina ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Bonanni, Laura ; Franciotti, Raffaella ; Onofrj, Marco ; Stirpe, Paola ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Fraioli, Lucia ; Parnetti, Lucilla ; Farotti, Lucia ; Pievani, Michela ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Triggiani, Antonio Ivano ; Taylor, John Paul ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Frisoni, Giovanni B. ; De Pandis, Maria Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-d0e936e29828206b68b980fa67b5b70912dbe46c2fb378633e236095cf2c1cbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Antiparkinson Agents - 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Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography. Compared with the normal older group, the PD groups showed reduced occipital alpha sources and increased widespread delta (<4 Hz) sources. Widespread frontal and temporal alpha sources exhibited an increase in PD with dementia compared with PD with mild cognitive impairment and PD with normal cognition groups, as function of dopamine depletion severity, typically greater in the former than the latter groups. A daily dose of levodopa induced a widespread reduction in cortical delta and alpha sources in a subgroup of 13 PD patients under standard chronic dopaminergic regimen. In PD patients in quiet wakefulness, alpha cortical source activations may reflect an excitatory effect of dopamine neuromodulation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30312790</pmid><doi>10.1016/j.neurobiolaging.2018.08.010</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7042-697X</orcidid><orcidid>https://orcid.org/0000-0001-6823-6069</orcidid><orcidid>https://orcid.org/0000-0003-3291-9452</orcidid><orcidid>https://orcid.org/0000-0001-9811-0897</orcidid><orcidid>https://orcid.org/0000-0002-1794-8987</orcidid><orcidid>https://orcid.org/0000-0001-6937-3065</orcidid><orcidid>https://orcid.org/0000-0002-5245-9839</orcidid><orcidid>https://orcid.org/0000-0001-7443-9233</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2019-01, Vol.73, p.9-20 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2119927623 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Antiparkinson Agents - pharmacology Antiparkinson Agents - therapeutic use Cerebral Cortex - physiopathology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Electroencephalography - drug effects Female Functional brain connectivity Humans Levodopa - pharmacology Levodopa - therapeutic use Male Mild cognitive impairment due to Alzheimer's disease (ADMCI) Mild cognitive impairment due to Parkinson's disease (PDMCI) Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson Disease - physiopathology Rest - physiology Resting state EEG rhythms |
| title | Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T21%3A25%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Levodopa%20may%20affect%20cortical%20excitability%20in%20Parkinson's%20disease%20patients%20with%20cognitive%20deficits%20as%20revealed%20by%20reduced%20activity%20of%20cortical%20sources%20of%20resting%20state%20electroencephalographic%20rhythms&rft.jtitle=Neurobiology%20of%20aging&rft.au=Babiloni,%20Claudio&rft.date=2019-01&rft.volume=73&rft.spage=9&rft.epage=20&rft.pages=9-20&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2018.08.010&rft_dat=%3Cproquest_cross%3E2119927623%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2119927623&rft_id=info:pmid/30312790&rft_els_id=S0197458018302938&rfr_iscdi=true |