Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT

Background/Aims: Aberrant expression of Tip60 is associated with progression in many cancers. However, the role of Tip60 in cancer progression remains contradictory. The aim of this study was to investigate the clinical significance, biological functions and underlying mechanisms of Tip60 deregulati...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2018-10, Vol.50 (2), p.612-628
Hauptverfasser:	Zhang, Yaodong, Ji, Guwei, Han, Sheng, Shao, Zicheng, Lu, Zefa, Huo, Liqun, Zhang, Jiawei, Yang, Renjie, Feng, Qinchao, Shen, Hao, Wang, Hongwei, Li, Xiangcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Care and treatment Cell adhesion & migration Cell cycle Cell Line, Tumor Cell Proliferation Cholangiocarcinoma Cholangiocarcinoma - metabolism Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Development and progression DNA repair Female Genetic aspects Health aspects Humans Kinases Lysine Acetyltransferase 5 - antagonists & inhibitors Lysine Acetyltransferase 5 - genetics Lysine Acetyltransferase 5 - metabolism Male Medical prognosis Metastasis Mice Mice, Inbred BALB C Mice, Nude Middle Aged Neoplasm Metastasis Original Paper Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Prevention Proliferation Prostate cancer Proteins Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction Software Tip60 Tumor suppressor genes
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