IRF-1 Intervention in the Classical ROS-Dependent Release of NETs during LPS-Induced Acute Lung Injury in Mice

Previously, we demonstrated that neutrophil extracellular traps (NETs) play an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism is unclear. In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenua...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Inflammation 2019-02, Vol.42 (1), p.387-403
Hauptverfasser:	Liu, Shuai, Yue, Yinyan, Pan, Pinhua, Zhang, Lemeng, Su, Xiaoli, Li, Haitao, Li, Haosi, Li, Yi, Dai, Minhui, Li, Qian, Mao, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Biomedical and Life Sciences Biomedicine Bronchus Classical pathway Immunology Interferon regulatory factor Interferon regulatory factor 1 Internal Medicine Leukocytes (neutrophilic) Lipopolysaccharides Lungs Original Article Pathology Pharmacology/Toxicology Platelets Reactive oxygen species Respiratory distress syndrome Respiratory therapy Rheumatology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!