Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis
Aim Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the...
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| Veröffentlicht in: | Geriatrics & gerontology international 2018-12, Vol.18 (12), p.1597-1602 |
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| creator | Kakio, Yuki Uchida, Haruhito A Takeuchi, Hidemi Okuyama, Yuka Okuyama, Michihiro Umebayashi, Ryoko Wada, Kentaro Sugiyama, Hitoshi Sugimoto, Ken Rakugi, Hiromi Kasahara, Shingo Wada, Jun |
| description | Aim
Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients.
Methods
A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end‐stage renal disease (DN group, n = 150) or not (Non‐DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty.
Results
The prevalence of frailty in the DN group was significantly higher than that in the Non‐DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non‐frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty.
Conclusions
The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597–1602. |
| doi_str_mv | 10.1111/ggi.13534 |
| format | Article |
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Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients.
Methods
A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end‐stage renal disease (DN group, n = 150) or not (Non‐DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty.
Results
The prevalence of frailty in the DN group was significantly higher than that in the Non‐DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non‐frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty.
Conclusions
The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597–1602.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.13534</identifier><identifier>PMID: 30311338</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Diabetes ; diabetes mellitus ; Diabetic nephropathy ; Frailty ; Glucose ; Hemodialysis ; kidney</subject><ispartof>Geriatrics & gerontology international, 2018-12, Vol.18 (12), p.1597-1602</ispartof><rights>2018 Japan Geriatrics Society</rights><rights>2018 Japan Geriatrics Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3774-ff9d9c772bb30f23c6c1affa98b4cce49d84db47f1182e9763fdbed2901afdb03</citedby><cites>FETCH-LOGICAL-c3774-ff9d9c772bb30f23c6c1affa98b4cce49d84db47f1182e9763fdbed2901afdb03</cites><orcidid>0000-0003-4981-2483 ; 0000-0002-7629-7678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.13534$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.13534$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30311338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kakio, Yuki</creatorcontrib><creatorcontrib>Uchida, Haruhito A</creatorcontrib><creatorcontrib>Takeuchi, Hidemi</creatorcontrib><creatorcontrib>Okuyama, Yuka</creatorcontrib><creatorcontrib>Okuyama, Michihiro</creatorcontrib><creatorcontrib>Umebayashi, Ryoko</creatorcontrib><creatorcontrib>Wada, Kentaro</creatorcontrib><creatorcontrib>Sugiyama, Hitoshi</creatorcontrib><creatorcontrib>Sugimoto, Ken</creatorcontrib><creatorcontrib>Rakugi, Hiromi</creatorcontrib><creatorcontrib>Kasahara, Shingo</creatorcontrib><creatorcontrib>Wada, Jun</creatorcontrib><title>Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis</title><title>Geriatrics & gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim
Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients.
Methods
A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end‐stage renal disease (DN group, n = 150) or not (Non‐DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty.
Results
The prevalence of frailty in the DN group was significantly higher than that in the Non‐DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non‐frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty.
Conclusions
The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597–1602.</description><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Diabetic nephropathy</subject><subject>Frailty</subject><subject>Glucose</subject><subject>Hemodialysis</subject><subject>kidney</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp10E1LwzAYB_AgitPpwS8gBS966JanSV9ylKlzMPDiziXNy5rRN5uW0W9vtk4Pgrkk8PyeP-GP0B3gGbgz327NDEhI6Bm6AkpjH4eMnh_f1IcwiSbo2todxhAzgEs0IZgAEJJcoc2L4ZnqjPAq1eRt3fAuHzxjPW5tLQzvlPT2pss93XJTdG5Uec4YVXV2HAi3Vbn9XJW1NLwYrLE36ELzwqrb0z1Fm7fXz8W7v_5YrhbPa1-QOKa-1kwyEcdBlhGsAyIiAVxrzpKMCqEokwmVGY01QBIoFkdEy0zJgGHHZIbJFD2OuU1bf_XKdmlprFBFwStV9zYNABiDKGTg6MMfuqv7tnK_cyqkLIhodAh8GpVoa2tbpdOmNSVvhxRweug6dV2nx66dvT8l9lmp5K_8KdeB-Qj2plDD_0npcrkaI78B4BKJXw</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Kakio, Yuki</creator><creator>Uchida, Haruhito A</creator><creator>Takeuchi, Hidemi</creator><creator>Okuyama, Yuka</creator><creator>Okuyama, Michihiro</creator><creator>Umebayashi, Ryoko</creator><creator>Wada, Kentaro</creator><creator>Sugiyama, Hitoshi</creator><creator>Sugimoto, Ken</creator><creator>Rakugi, Hiromi</creator><creator>Kasahara, Shingo</creator><creator>Wada, Jun</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4981-2483</orcidid><orcidid>https://orcid.org/0000-0002-7629-7678</orcidid></search><sort><creationdate>201812</creationdate><title>Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis</title><author>Kakio, Yuki ; Uchida, Haruhito A ; Takeuchi, Hidemi ; Okuyama, Yuka ; Okuyama, Michihiro ; Umebayashi, Ryoko ; Wada, Kentaro ; Sugiyama, Hitoshi ; Sugimoto, Ken ; Rakugi, Hiromi ; Kasahara, Shingo ; Wada, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3774-ff9d9c772bb30f23c6c1affa98b4cce49d84db47f1182e9763fdbed2901afdb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Diabetic nephropathy</topic><topic>Frailty</topic><topic>Glucose</topic><topic>Hemodialysis</topic><topic>kidney</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kakio, Yuki</creatorcontrib><creatorcontrib>Uchida, Haruhito A</creatorcontrib><creatorcontrib>Takeuchi, Hidemi</creatorcontrib><creatorcontrib>Okuyama, Yuka</creatorcontrib><creatorcontrib>Okuyama, Michihiro</creatorcontrib><creatorcontrib>Umebayashi, Ryoko</creatorcontrib><creatorcontrib>Wada, Kentaro</creatorcontrib><creatorcontrib>Sugiyama, Hitoshi</creatorcontrib><creatorcontrib>Sugimoto, Ken</creatorcontrib><creatorcontrib>Rakugi, Hiromi</creatorcontrib><creatorcontrib>Kasahara, Shingo</creatorcontrib><creatorcontrib>Wada, Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kakio, Yuki</au><au>Uchida, Haruhito A</au><au>Takeuchi, Hidemi</au><au>Okuyama, Yuka</au><au>Okuyama, Michihiro</au><au>Umebayashi, Ryoko</au><au>Wada, Kentaro</au><au>Sugiyama, Hitoshi</au><au>Sugimoto, Ken</au><au>Rakugi, Hiromi</au><au>Kasahara, Shingo</au><au>Wada, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2018-12</date><risdate>2018</risdate><volume>18</volume><issue>12</issue><spage>1597</spage><epage>1602</epage><pages>1597-1602</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim
Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients.
Methods
A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end‐stage renal disease (DN group, n = 150) or not (Non‐DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty.
Results
The prevalence of frailty in the DN group was significantly higher than that in the Non‐DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non‐frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty.
Conclusions
The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597–1602.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>30311338</pmid><doi>10.1111/ggi.13534</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4981-2483</orcidid><orcidid>https://orcid.org/0000-0002-7629-7678</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Diabetes diabetes mellitus Diabetic nephropathy Frailty Glucose Hemodialysis kidney |
| title | Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis |
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