A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation

Abstract Aims Arrhythmogenic cardiomyopathy (AC) is one of the most common inherited cardiomyopathies, characterized by progressive fibro-fatty replacement in the myocardium. Clinically, AC manifests itself with ventricular arrhythmias, syncope, and sudden death and shows wide inter- and intra-famil...

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Veröffentlicht in:	Cardiovascular research 2019-03, Vol.115 (4), p.739-751
Hauptverfasser:	Calore, Martina, Lorenzon, Alessandra, Vitiello, Libero, Poloni, Giulia, Khan, Mohsin A F, Beffagna, Giorgia, Dazzo, Emanuela, Sacchetto, Claudia, Polishchuk, Roman, Sabatelli, Patrizia, Doliana, Roberto, Carnevale, Daniela, Lembo, Giuseppe, Bonaldo, Paolo, De Windt, Leon, Braghetta, Paola, Rampazzo, Alessandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmogenic Right Ventricular Dysplasia - genetics Arrhythmogenic Right Ventricular Dysplasia - metabolism Arrhythmogenic Right Ventricular Dysplasia - pathology Codon, Nonsense Desmoglein 2 - genetics Disease Models, Animal Fibrosis Gene Expression Regulation Gene Regulatory Networks Genetic Predisposition to Disease Mice, Inbred C57BL Mice, Transgenic MicroRNAs - genetics MicroRNAs - metabolism Myocardium - metabolism Myocardium - ultrastructure Phenotype Transcriptome Wnt Signaling Pathway - genetics
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