Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury

Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including regulating cell excitability, synaptic transmission,...

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Veröffentlicht in:	Glia 2019-01, Vol.67 (1), p.78-90
Hauptverfasser:	Su, Wen‐Feng, Wu, Fan, Jin, Zi‐Han, Gu, Yun, Chen, Ying‐Ting, Fei, Ying, Chen, Hui, Wang, Ya‐Xian, Xing, Ling‐Yan, Zhao, Ya‐Yu, Yuan, Ying, Tang, Xin, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Brain-derived neurotrophic factor Central nervous system Excitability Injuries Lysosomes Microglia Motors Myelination nerve injury Nerves Nervous system P2X4R Pain Peripheral nervous system Peripheral neuropathy Protein biosynthesis Proteins Recovery Recovery of function Regrowth Schwann cell Schwann cells Secretion Synaptic transmission
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